Helicobacter pylori Entry into Human Gastric Epithelial Cells: A Potential Determinant of Virulence, Persistence, and Treatment Failures

Helicobacter

Volumn 5, Issue 3, 2000, Pages 148-154

  Björkholm, Britta ^a,b   Zhukhovitsky, Vladimir ^a   Löfman, Carl ^c   Hultén, Kristina ^a   Enroth, Helena ^a,b   Block, Mats ^d   Rigo, Robert ^a   Falk, Per ^b,e   Engstrand, Lars ^a,b,f  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Swedish Television   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

^e ASTRAZENECA R AND D   (Sweden)

^f SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; VACA PROTEIN, HELICOBACTER PYLORI;

ANTIBIOTIC RESISTANCE; ARTICLE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; GENETICS; HELICOBACTER PYLORI; HUMAN; METABOLISM; METHODOLOGY; MICROBIOLOGY; MUTATION; PATHOGENICITY; PHOTOGRAPHY; STOMACH MUCOSA; TREATMENT FAILURE; VIRULENCE;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; DRUG RESISTANCE, MICROBIAL; EPITHELIAL CELLS; GASTRIC MUCOSA; HELICOBACTER PYLORI; HUMANS; MUTATION; PHOTOGRAPHY; TREATMENT FAILURE; VIRULENCE;

EID: 0034264555     PISSN: 10834389     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-5378.2000.00023.x     Document Type: Article

References (27)

1. Blaser MJ. Ecology of Helicobacter pylori in the human stomach. J Clin Invest 1997;100:759-62.
2. Bode G, Malfertheiner P, Ditschuneit H. Pathogenic implications of ultrastructural findings in Campylobacter pylori-related gastroduodenal disease. Scand J Gastroenterol 1988;23(suppl 142):25-39.
3. Engstrand L, Graham DY, Scheynius A, Genta RM, El-Zaatari FAK. Is the sanctuary where Helicobacter pylori avoids antibacterial treatment intracellular? Am J Clin Pathol 1997;108:504-9.
4. Noach LA, Rolf TM, Tytgat GNJ. Electron microscopic study of association between Helicobacter pylori and gastric and duodenal mucosa. J Clin Pathol 1994;47:699-704.
5. Steer HW. Ultrastructure of cell migration through the gastric epithelium and its relationship to bacteria. J Clin Pathol 1975;28:639-46.
6. Ko GH, Kang SM, Kim YK, Lee JH, Park CK, Youn HS, Baik SC, Cho MJ, Lee WK, Rhee KH. Invasiveness of Helicobacter pylori into human gastric mucosa. Helicobacter 1999;4:77-81.
7. Su B, Johansson S, Fällman M, Patarroyo M, Granström M, Normark S. Signal transduction mediated adherence and entry of Helicobacter pylori into cultured cells. Gastroenterology 1999;117:595-604.
8. Rakita RM. Intracellular activity, potential clinical uses of antibiotics. ASM News 1998;64:570-4.
9. Hessey SJ, Spencer J, Wyatt JI, Sobala G, Rathbone BJ, Axon AT, Dixon MF. Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis. Gut 1990;31:134-8.
10. Segal ED, Lange C, Covacci A, Tompkins LS, Falkow S. Induction of host signal transduction pathways by Helicobacter pylori. Proc Natl Acad Sci USA 1997;94:7595-9.
11. Finlay BB, Falkow S. Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 1997;61:136-69.
12. Penston JG. Review article: Clinical aspects of Helicobacter pylori eradication therapy in peptic ulcer disease. Aliment Pharmacol Ther 1996;10:469-86.
13. Evans DG, Evans DJ, Graham DY. Adherence and internalization of Helicobacter pylori by HEp-2 cells. Gastroenterology 1992;102:1557-67.
14. Hultén K, Cars O, Hjelm E, Engstrand E. In vitro activity of azitromycin against intracellular Helicobacter pylori. J Antimicrob Chemother 1996;37: 483-9.
15. Jenks PJ, Foynes S, Ward SJ, Constantinidou C, Penn CW, Wren BW. A flagellar-specific ATPase (FliI) is necessary for flagellar export in Helicobacter pylori. FEMS Microbiol Lett 1997;152:205-11.
16. Tomb JF, White O, Kerlavage AR, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997;388:539-47.
17. Covacci A, Rappuoli R. Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med 2000;191:587-92.
18. Lofman C, Rigo R, Block M, Hultén K, Enroth H, Engstrand L. Bacterium-host interactions monitored by time-lapse photography. Nature Med 1997;3:930-1.
19. Segal ED, Cha J, Eo J, Falkow S, Tompkins LS. Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 1999;96:14559-64.
20. Janzon L, Johanson U, Phadnis S. Construction of a Helicobacter pylori cytotoxin negative mutant [abstract]. First open meeting of the European Helicobacter pylori Study Group on Immunology in Helicobacter infections, Elsinore, Helsingor, Denmark, June 1995.
21. Hazell SL, Evans DJ, Graham DY. Helicobacter pylori catalase. J Gen Microbiol 1991;137:57-61.
22. Terano A, Mach T, Stachura J, Sekhon S, Tarnawski A, Ivey J. A monolayer culture of human gastric epithelial cells. Dig Dis Sci 1983;28:595-603.
23. www.smittskyddsinstitutet.se/archive.asp?theSection-10
24. Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 1977;31:107-33.
25. McCartney AL, Wenzhi W, Tannock GV. Molecular analysis of the composition of the bifidobacterial and lactobacillus microflora of humans. Appl Environ Microbiol 1996;62:4608-13.
26. Hultén K, Rigo R, Gustavsson I, Engstrand L. New pharmacokinetic in vitro model for studies on antibiotic activity against intracellular microorganisms. Antimicrob Agents Chemother 1996;40:2727-31.
27. Harris AW, Misiewicz JJ. In: Eradication of Helicobacter pylori. Calam J, ed. Baillière's Clinical Gastroenterology: 9. Helicobacter pylori. London: Baillère Tindall, 1995:583-613.