Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells

International Immunopharmacology

Volumn 1, Issue 11, 2001, Pages 1969-1978

  Han, Sang B ^a   Park, Se H ^a   Lee, Ki H ^a   Lee, Chang W ^a   Lee, Sang H ^a   Kim, Hyoung C ^a   Kim, Young S ^b   Lee, Hyun S ^a   Kim, Hwan M ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

B cells; Macrophages; Platycodon grandiflorum; Polysaccharide; T cells

Indexed keywords

ANTIGEN; CD11B ANTIGEN; CD14 ANTIGEN; CD19 ANTIGEN; CD79B ANTIGEN; CONCANAVALIN A; IMMUNOGLOBULIN M; IMMUNOSTIMULATING AGENT; INTERLEUKIN 2; INTERLEUKIN 4; KRESTIN; LENTINAN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT EXTRACT; PLATYCODON GRANDIFLORUM EXTRACT; POLYCLONAL ANTIBODY; POLYMYXIN B; POLYSACCHARIDE; SCHIZOPHYLLAN; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL SPECIFICITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG ISOLATION; DRUG SPECIFICITY; ENZYME ACTIVATION; FEMALE; IMMUNIZATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PLANT; PLANT ROOT; PLATYCODON GRANDIFLORUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHEEP ERYTHROCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODY FORMATION; B-LYMPHOCYTES; BIOLOGICAL RESPONSE MODIFIERS; CAMPANULACEAE; CELL DIVISION; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNITY, CELLULAR; IMMUNOGLOBULIN M; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED STRAINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PLANTS, MEDICINAL; POLYMYXIN B; POLYSACCHARIDES; RECEPTORS, CELL SURFACE; SPLEEN; T-LYMPHOCYTES;

EID: 0034845702     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00124-2     Document Type: Article

References (33)

1. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes
2. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus
3. Mushrooms, tumors, and immunity
4. Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides
5. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai
6. Activation of NF-kappaB/Rel in angelan-stimulated macrophages
7. Differential activation of murine macrophages by angelan and LPS
8. The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis
9. Effects of Platycodon grandiflorum feeding on serum and liver lipid concentrations in rats with diet-induced hyperlipidemia
10. Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats
11. A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis
12. Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity
13. Determination of sulfite in Oriental herbal medicines
14. Studies on the conformational aspects of inulin oligomers
15. T-cell specific immunosuppression by prodigiosin isolated from Serratia marcescens
16. Rapid determination of in vivo and in vitro antibody responses by suspension hemolytic assay
17. Macrophage cytotoxicity: Role for l-arginine deiminase and imino nitrogen oxidation to nitrite
18. Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B
19. Lentinan, a new immuno-accelerator of cell-mediated responses
20. Selective suppression of T-cell activity in tumor-bearing mice and its improvement by lentinan, a potent anti-tumor polysaccharide
21. Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses
22. Reconstitution of anti-tumor effects of lentinan in nude mice: Roles of delayed-type hypersensitivity reaction triggered by CD4-positive T cell clone in the infiltration of effector cells into tumor
23. Curative effects of combination therapy with lentinan and interleukin-2 against established murine tumors, and the role of CD8-positive T cells
24. Influence of the sequence of administration of beta-glucans and a Vibrio damsela vaccine on the immune response of turbot (Scophthalmus maximus L.)
25. B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus
26. Growth inhibition of transplantable mouse tumors by non-digestible carbohydrates
27. Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin
28. Possible mechanisms by which pro- and prebiotics influence colon carcinogenesis and tumor growth
29. Inulin, oligofructose and intestinal function
30. Co-receptors on B lymphocytes
31. Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein
32. Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells