Microbial translocation in chronic liver diseases

International Journal of Microbiology

Volumn , Issue , 2012, Pages

  Pinzone, Marilia Rita ^a   Celesia, Benedetto Maurizio ^a   Di Rosa, Michele ^a   Cacopardo, Bruno ^a   Nunnari, Giuseppe ^a,b  

^a UNIVERSITY OF CATANIA   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84864950207     PISSN: 1687918X     EISSN: 16879198     Source Type: Journal    
DOI: 10.1155/2012/694629     Document Type: Review

References (166)

1. Abt M. C., Artis D., The intestinal microbiota in health and disease: the influence of microbial products on immune cell homeostasis Current Opinion in Gastroenterology 2009 25 6 496 502
2. Garcia-Tsao G., Wiest R., Gut microflora in the pathogenesis of the complications of cirrhosis Best Practice and Research 2004 18 2 353 372 (Pubitemid 38444136)
3. Schaffert C. S., Duryee M. J., Hunter C. D., Hamilton B. C., DeVeney A. L., Hueter M. M., Klassen L. W., Thiele G. M., Alcohol metabolites and lipopolysaccharide: roles in the development and/or progression of alcoholic liver disease World Journal of Gastroenterology 2009 15 10 1209 1218
4. Tilg H., Moschen A. R., Kaser A., Obesity and the microbiota Gastroenterology 2009 136 5 1476 1483
5. Cani P. D., Delzenne N. M., The role of the gut microbiota in energy metabolism and metabolic disease Current Pharmaceutical Design 2009 15 13 1546 1558
6. Wiest R., Rath H. C., Bacterial translocation in the gut Bailliere's Best Practice and Research in Clinical Gastroenterology 2003 17 3 397 425
7. Berg R. D., Garlington A. W., Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model Infection and Immunity 1979 23 2 403 411 (Pubitemid 9119845)
8. Steffen E. K., Berg R. D., Deitch E. A., Comparison of translocation rates of various indigenous bacteria from the gastrointestinal tract to the mesenteric lymph node Journal of Infectious Diseases 1988 157 5 1032 1038
9. Wells C. L., Colonization and translocation of intestinal bacterial flora Transplantation Proceedings 1996 28 5 2653 2656 (Pubitemid 26339435)
10. Wells C. L., Maddaus M. A., Reynolds C. M., Jechorek R. P., Simmons R. L., Role of anaerobic flora in the translocation of aerobic and facultatively anaerobic intestinal bacteria Infection and Immunity 1987 55 11 2689 2694 (Pubitemid 17154509)
11. Garcia-Tsao G., Lee F. A. Y., Barden G. E., Cartun R., West A. B., Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites Gastroenterology 1995 108 6 1835 1841
12. Llovet J. M., Bartoli R., Planas R., Cabre E., Jimenez M., Urban A., Ojanguren I., Arnal J., Gassull M. A., Bacterial translocation in cirrhotic rats. Its role in the development of spontaneous bacterial peritonitis Gut 1994 35 11 1648 1652 (Pubitemid 24339271)
13. Runyon B. A., Squier S., Borzio M., Translocation of gut bacteria in rats with cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis Journal of Hepatology 1994 21 5 792 796 (Pubitemid 24374146)
14. Llovet J. M., Bartol R., March F., Planas R., Viado B., Cabré E., Arnal J., Coll P., Ausina V., Gassull M. A., Translocated intestinal bacteria cause spontaneous bacterial peritonitis in cirrhotic rats: molecular epidemiologic evidence Journal of Hepatology 1998 28 2 307 313 (Pubitemid 28116439)
15. Cirera I., Bauer T. M., Navasa M., Bacterial translocation of enteric organisms in patients with cirrhosis Journal of Hepatology 2001 34 1 32 37
16. Genesc J., Mart R., Rojo F., Campos F., Peribez V., Gnzalez A., Castells L., Ruiz-Marcelln C., Margarit C., Esteban R., Guardia J., Segura R., Increased tumour necrosis factor production in mesenteric lymph nodes of cirrhotic patients with ascites Gut 2003 52 7 1054 1059 (Pubitemid 36765301)
17. Such J., Francés R., Muoz C., Zapater P., Casellas J. A., Cifuentes A., Rodrguez-Valera F., Pascual S., Sola-Vera J., Carnicer F., Uceda F., Palazn J. M., Pérez-Mateo M., Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites Hepatology 2002 36 1 135 141 (Pubitemid 34700770)
18. Zapater P., Francés R., Gonzlez-Navajas J. M., De la Hoz M. A., Moreu R., Pascual S., Monfort D., Montoliu S., Vila C., Escudero A., Torras X., Cirera I., Llanos L., Guarner-Argente C., Palazn J. M., Carnicer F., Bellot P., Guarner C., Planas R., Sol R., Serra M. A., Muoz C., Pérez-Mateo M., Such J., Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis Hepatology 2008 48 6 1924 1931
19. Francés R., Muoz C., Zapater P., Uceda F., Gascn I., Pascual S., Pérez-Mateo M., Such J., Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites Gut 2004 53 6 860 864 (Pubitemid 38662137)
20. Bauer T. M., Schwacha H., Steinbrckner B., Brinkmann F. E., Ditzen A. K., Aponte J. J., Pelz K., Berger D., Kist M., Blum H. E., Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia American Journal of Gastroenterology 2002 97 9 2364 2370
21. Bode C., Kolepke R., Schafer K., Bode J., Breath hydrogen excretion in patients with alcoholic liver diseaseevidence of small intestinal bacterial overgrowth Zeitschrift fur Gastroenterologie 1993 31 1 3 7 (Pubitemid 23046154)
22. Yang C. Y., Chang C. S., Chen G. H., Small-intestinal bacterial overgrowth in patients with liver cirrhosis, diagnosed with glucose H 2 or CH 4 breath tests Scandinavian Journal of Gastroenterology 1998 33 8 867 871
23. Pardo A., Bartol R., Lorenzo-Zniga V., Planas R., Viado B., Riba J., Cabré E., Santos J., Luque T., Ausina V., Gassull M. A., Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis Hepatology 2000 31 4 858 863 (Pubitemid 30169931)
24. Bauer T. M., Schwacha H., Steinbrckner B., Brinkmann F. E., Ditzen A. K., Kist M., Blum H. E., Diagnosis of small intestinal bacterial overgrowth in patients with cirrhosis of the liver: poor performance of the glucose breath hydrogen test Journal of Hepatology 2000 33 3 382 386 (Pubitemid 30663375)
25. Shindo K., Machida M., Miyakawa K., Fukumura M., A syndrome of cirrhosis, achlorhydria, small intestinal bacterial overgrowth, and fat malabsorption American Journal of Gastroenterology 1993 88 12 2084 2091 (Pubitemid 23352176)
26. Madrid A. M., Cumsille F., Defilippi C., Altered small bowel motility in patients with liver cirrhosis depends on severity of liver disease Digestive Diseases and Sciences 1997 42 4 738 742 (Pubitemid 27196023)
27. Sadik R., Abrahamsson H., Bjrnsson E., Gunnarsdottir A., Stotzer P. O., Etiology of portal hypertension may influence gastrointestinal transit time Scandinavian Journal of Gastroenterology 2003 38 10 1039 1044 (Pubitemid 37352466)
28. Husebye E., Hellstrm P. M., Sundler F., Chen J., Midtvedt T., Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats American Journal of Physiology 2001 280 3 G368 G380
29. Liu M. T., Rothstein J. D., Gershon M. D., Kirchgessner A. L., Glutamatergic enteric neurons Journal of Neuroscience 1997 17 12 4764 4784 (Pubitemid 27246933)
30. Zhang S. C., Wang W., Ren W. Y., He B. M., Zhou K., Zhu W. N., Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis World Journal of Gastroenterology 2003 9 3 534 538 (Pubitemid 36372122)
31. Pérez-Paramo M., Munoz J., Albillos A., Freile I., Portero F., Santos M., Ortiz-Berrocal J., Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites Hepatology 2000 31 1 43 48 (Pubitemid 30033687)
32. Madrid A. M., Hurtado C., Venegas M., Cumsille F., Defilippi C., Long-term treatment with cisapride and antibiotics in liver cirrhosis: effect on small intestinal motility, bacterial overgrowth, and liver function American Journal of Gastroenterology 2001 96 4 1251 1255 (Pubitemid 32319169)
33. Slocum M. M., Sittig K. M., Specian R. D., Deitch E. A., Absence of intestinal bile promotes bacterial translocation American Surgeon 1992 58 5 305 310
34. Lorenzo-Ziga V., Bartol R., Planas R., Hofmann A. F., Viado B., Hagey L. R., Hernndez J. M., Maé J., Alvarez M. A., Ausina V., Gassull M. A., Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats Hepatology 2003 37 3 551 557 (Pubitemid 36258776)
35. Rimola A., Soto R., Boro F., Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis Hepatology 1984 4 1 53 58 (Pubitemid 14185424)
36. Finlayson N. D., Krohn K., Fauconnet M. H., Anderson K. E., Significance of serum complement levels in chronic liver disease Gastroenterology 1972 63 4 653 659
37. Homann C., Varming K., Hgsen K., Mollnes T. E., Graudal N., Thomsen A.. C., Garred P., Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality Gut 1997 40 4 544 549 (Pubitemid 27204939)
38. Hassner A., Kletter Y., Jedvab M., Impaired monocyte function in liver cirrhosis The Lancet 1979 1 8111 329 330 (Pubitemid 9104639)
39. Rajkovic I. A., Williams R., Abnormalities of neutrophil phagocytosis, intracellular killing and metabolic activity in alcoholic cirrhosis and hepatitis Hepatology 1986 6 2 252 262 (Pubitemid 16144876)
40. Inamura T., Miura S., Tsuzuki Y., Hara Y., Hokari R., Ogawa T., Teramoto K., Watanabe C., Kobayashi H., Nagata H., Ishii H., Alteration of intestinal intraepithelial lymphocytes and increased bacterial translocation in a murine model of cirrhosis Immunology Letters 2003 90 1 3 11 (Pubitemid 37386285)
41. Misra V., Misra S. P., Dwivedi M., Gupta S. C., Histomorphometric study of portal hypertensive enteropathy American Journal of Clinical Pathology 1997 108 6 652 657 (Pubitemid 27506231)
42. Such J. V., Guardiola J. V., de Juan J., Casellas J. A., Pascual S., Aparicio J. R., Sol-Vera J., Pérez-Mateo M., Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis European Journal of Gastroenterology and Hepatology 2002 14 4 371 376 (Pubitemid 34439034)
43. Ramachandran A., Prabhu R., Thomas S., Reddy J. B., Pulimood A., Balasubramanian K. A., Intestinal mucosal alterations in experimental cirrhosis in the rat: role of oxygen free radicals Hepatology 2002 35 3 622 629 (Pubitemid 34183967)
44. Chiva M., Guarner C., Peralta C., Llovet T., Gmez G., Soriano G., Balanz J., Intestinal mucosal oxidative damage and bacterial translocation in cirrhotic rats European Journal of Gastroenterology and Hepatology 2003 15 2 145 150 (Pubitemid 36269778)
45. Zuckerman M. J., Menzies I. S., Ho H., Gregory G. G., Casner N. A., Crane R. S., Hernandez J. A., Assessment of intestinal permeability and absorption in cirrhotic patients with ascites using combined sugar probes Digestive Diseases and Sciences 2004 49 4 621 626 (Pubitemid 38992551)
46. Pascual S., Such J., Esteban A., Zapater P., Casellas J. A., Aparicio J. R., Girona E., Gutiérrez A., Carnices F., Palazn J. M., Sola-Vera J., Pérez-Mateo M., Intestinal permeability is increased in patients with advanced cirrhosis Hepato-Gastroenterology 2003 50 53 1482 1486 (Pubitemid 37186515)
47. Cariello R., Federico A., Sapone A., Tuccillo C., Scialdone V. R., Tiso A., Miranda A., Portincasa P., Carbonara V., Palasciano G., Martorelli L., Esposito P., Carten M., Del Vecchio Blanco C., Loguercio C., Intestinal permeability in patients with chronic liver diseases: its relationship with the aetiology and the entity of liver damage Digestive and Liver Disease 2010 42 3 200 204
48. Di Leo V., Venturi C., Baragiotta A., Martines D., Floreani A., Gastroduodenal and intestinal permeability in primary biliary cirrhosis European Journal of Gastroenterology and Hepatology 2003 15 9 967 973 (Pubitemid 37094295)
49. Salzman A. L., Menconi M. J., Unno N., Ezzell R. M., Casey D. M., Gonzalez P. K., Fink M. P., Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers American Journal of Physiology 1995 268 2 G361 G373
50. Lin R. S., Lee F. Y., Lee S. D., Tsai Y. T., Lin H. C., Lu R. H., Hsu W. C., Huang C. C., Wang S. S., Lo K. J., Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation Journal of Hepatology 1995 22 2 165 172
51. Bigatello L. M., Broitman S. A., Fattori L., Endotoxemia, encephalopathy, and mortality in cirrhotic patients American Journal of Gastroenterology 1987 82 1 11 15 (Pubitemid 17231676)
52. Wiest R., Cadelina G., Milstien S., McCuskey R. S., Garcia-Tsao G., Groszmann R. J., Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats Hepatology 2003 38 6 1508 1515 (Pubitemid 37466977)
53. Mainous M. R., Ertel W., Chaudry I. H., Deitch E. A., The gut: a cytokine-generating organ in systemic inflammation? Shock 1995 4 3 193 199
54. Deitch E. A., Xu D., Franko L., Ayala A., Chaudry I. H., Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock Shock 1994 1 2 141 145
55. Iimuro Y., Gallucci R. M., Luster M. I., Kono H., Thurman R. G., Antibodies to tumor necrosis factor attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat Hepatology 1997 26 6 1530 1537 (Pubitemid 27520019)
56. Enomoto N., Ikejima K., Bradford B. U., Rivera C. A., Kono H., Goto M., Yamashina S., Schemmer P., Kitamura T., Oide H., Takei Y., Hirose M., Shimizu H., Miyazaki A., Brenner D. A., Sato N., Thurman R. G., Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury Journal of Gastroenterology and Hepatology 2000 15 D20 D25 (Pubitemid 30190721)
57. Yin M., Wheeler M. D., Kono H., Bradford B. U., Gallucci R. M., Luster M. I., Thurman R. G., Essential role of tumor necrosis factor in alcohol-induced liver injury in mice Gastroenterology 1999 117 4 942 952 (Pubitemid 29468238)
58. Wiest R., Das S., Cadelina G., Garcia-Tsao G., Milstien S., Groszmann R. J., Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility Journal of Clinical Investigation 1999 104 9 1223 1233 (Pubitemid 29536293)
59. Albillos A., de la Hera A., Gonzlez M., Moya J. L., Calleja J. L., Monserrat J., Ruiz-del-Arbol L., Alvarez-Mon M., Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement Hepatology 2003 37 1 208 217 (Pubitemid 36042162)
60. Tilg H., Wilmer A., Vogel W., Herold M., Nolchen B., Judmaier G., Huber C., Serum levels of cytokines in chronic liver diseases Gastroenterology 1992 103 1 264 274
61. Schafer C., Schips I., Landig J., Bode J. C., Bode C., Tumor-necrosis-factor and interleukin-6 response of peripheral blood monocytes to low concentrations of lipopolysaccharide in patients with alcoholic liver disease Zeitschrift fur Gastroenterologie 1995 33 9 503 508
62. Deviere J., Content J., Denys C., Vandenbussche P., Le Moine O., Schandene L., Vaerman J. P., Dupont E., Immunoglobulin A and interleukin 6 form a positive secretory feedback loop: A study of normal subjects and alcoholic cirrhotics Gastroenterology 1992 103 4 1296 1301
63. Khoruts A., Stahnke L., McClain C. J., Logan G., Allen J. I., Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients Hepatology 1991 13 2 267 276
64. von Baehr V., Dcke W. D., Plauth M., Liebenthal C., Kpferling S., Lochs H., Baumgarten R., Volk H. D., Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation Gut 2000 47 2 281 287 (Pubitemid 30489775)
65. Chan C. C., Hwang S. J., Lee F. Y., Wang S. S., Chang F. Y., Li C. P., Chu C. J., Lu R. H., Lee S. D., Prognostic value of plasma endotoxin levels in patients with cirrhosis Scandinavian Journal of Gastroenterology 1997 32 9 942 946 (Pubitemid 27382041)
66. Riordan S. M., Skinner N., Nagree A., McCallum H., McIver C. J., Kurtovic J., Hamilton J. A., Bengmark S., Williams R., Visvanathan K., Peripheral blood mononuclear cell expression of toll-like receptors and relation to cytokine levels in cirrhosis Hepatology 2003 37 5 1154 1164 (Pubitemid 36538693)
67. Visap J. P., Tillonen J., Salaspuro M., Microbes and mucosa in the regulation of intracolonic acetaldehyde concentration during ethanol challenge Alcohol and Alcoholism 2002 37 4 322 326 (Pubitemid 34830908)
68. Bode C., Bode J. C., Effect of alcohol consumption on the gut Bailliere's Best Practice and Research in Clinical Gastroenterology 2003 17 4 575 592
69. Ferrier L., Bérard F., Debrauwer L., Chabo C., Langella P., Buéno L., Fioramonti J., Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents American Journal of Pathology 2006 168 4 1148 1154
70. Rao R. K., Acetaldehyde-induced barrier disruption and paracellular permeability in Caco-2 cell monolayer Methods in Molecular Biology 2008 447 171 183
71. Parlesak A., Schfer C., Schtz T., Bode J. C., Bode C., Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease Journal of Hepatology 2000 32 5 742 747 (Pubitemid 30262733)
72. Bode C., Bode J. C., Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol? Alcoholism 2005 29 11 166S 171S (Pubitemid 43194346)
73. Seki E., De Minicis S., sterreicher C. H., Kluwe J., Osawa Y., Brenner D. A., Schwabe R. F., TLR4 enhances TGF- signaling and hepatic fibrosis Nature Medicine 2007 13 11 1324 1332 (Pubitemid 350073596)
74. Yan A. W., Fouts D. E., Brandl J., Strkel P., Torralba M., Schott E., Tsukamoto H., Nelson K. E., Brenner D. A., Schnabl B., Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology 2011 53 1 96 105
75. Bode J. C., Bode C., Heidelbach R., Jejunal microflora in patients with chronic alcohol abuse Hepato-Gastroenterology 1984 31 1 30 34 (Pubitemid 14091895)
76. Morencos F. C., de las Heras Castao G., Martn Ramos L., Small bowel bacterial overgrowth in patients with alcoholic cirrhosis Digestive Diseases and Sciences 1995 40 6 1252 1256
77. Hauge T., Persson J., Danielsson D., Mucosal bacterial growth in the upper gastrointestinal tract in alcoholics (heavy drinkers) Digestion 1997 58 6 591 595 (Pubitemid 27515726)
78. Tang Y., Forsyth C. B., Farhadi A., Rangan J., Jakate S., Shaikh M., Banan A., Fields J. Z., Keshavarzian A., Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage Alcoholism 2009 33 7 1220 1230
79. Keshavarzian A., Farhadi A., Forsyth C. B., Rangan J., Jakate S., Shaikh M., Banan A., Fields J. Z., Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats Journal of Hepatology 2009 50 3 538 547
80. Banan A., Fields J. Z., Decker H., Zhang Y., Keshavarzian A., Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction Journal of Pharmacology and Experimental Therapeutics 2000 294 3 997 1008 (Pubitemid 30666852)
81. Banan A., Keshavarzian A., Zhang L., Shaikh M., Forsyth C. B., Tang Y., Fields J. Z., NF- B activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium Alcohol 2007 41 6 447 460 (Pubitemid 47554481)
82. Kolios G., Valatas V., Ward S. G., Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle Immunology 2004 113 4 427 437 (Pubitemid 39593361)
83. Jerrells T. R., Peritt D., Marietta C., Eckardt M. J., Mechanisms of suppression of cellular immunity induced by ethanol Alcoholism 1989 13 4 490 493 (Pubitemid 19219734)
84. Sibley D., Jerrells T. R., Alcohol consumption by C57BL/6 mice is associated with depletion of lymphoid cells from the gut-associated lymphoid tissues and altered resistance to oral infections with Salmonella typhimurium Journal of Infectious Diseases 2000 182 2 482 489 (Pubitemid 30651045)
85. Sozinov A. S., Systemic endotoxemia during chronic viral hepatitis Bulletin of Experimental Biology and Medicine 2002 133 2 153 155
86. Sandler N. G., Koh C., Roque A., Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection Gastroenterology 2011 141 4 1220 1230
87. Marchetti G., Nasta P., Bai F., Circulating sCD14 is associated with virological response to pegylated-interferon- /ribavirin treatment in HIV/HCV co-infected patients PLoS ONE 2012 7 2
88. Balagopal A., Philp F. H., Astemborski J., Block T. M., Mehta A., Long R., Kirk G. D., Mehta S. H., Cox A. L., Thomas D. L., Ray S. C., Human immunodeficiency virus-related microbial translocation and progression of hepatitis C Gastroenterology 2008 135 1 226 233 (Pubitemid 351899010)
89. Brun P., Castagliuolo I., Di Leo V., Buda A., Pinzani M., Pal G., Martines D., Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis American Journal of Physiology 2007 292 2 G518 G525
90. Farhadi A., Gundlapalli S., Shaikh M., Frantzides C., Harrell L., Kwasny M. M., Keshavarzian A., Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis Liver International 2008 28 7 1026 1033 (Pubitemid 352044451)
91. Miele L., Valenza V., La Torre G., Montalto M., Cammarota G., Ricci R., Mascian R., Forgione A., Gabrieli M. L., Perotti G., Vecchio F. M., Rapaccini G., Gasbarrini G., Day C. P., Grieco A., Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease Hepatology 2009 49 6 1877 1887
92. Wigg A. J., Roberts-Thomson I. C., Grose R. H., Cummins A. G., Dymock R. B., McCarthy P. J., The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor in the pathogenesis of non-alcoholic steatohepatitis Gut 2001 48 2 206 211 (Pubitemid 32141844)
93. Cani P. D., Bibiloni R., Knauf C., Waget A., Neyrinck A. M., Delzenne N. M., Burcelin R., Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 2008 57 6 1470 1481
94. Cani P. D., Amar J., Iglesias M. A., Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 2007 56 7 1761 1772 (Pubitemid 47025442)
95. Griffiths E. A., Duffy L. C., Schanbacher F. L., Qiao H., Dryja D., Leavens A., Rossman J., Rich G., Dirienzo D., Ogra P. L., In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb/c mice Digestive Diseases and Sciences 2004 49 4 579 589 (Pubitemid 38992545)
96. Bergheim I., Weber S., Vos M., Krmer S., Volynets V., Kaserouni S., McClain C. J., Bischoff S. C., Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin Journal of Hepatology 2008 48 6 983 992
97. Spruss A., Kanuri G., Wagnerberger S., Haub S., Bischoff S. C., Bergheim I., Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice Hepatology 2009 50 4 1094 1104
98. Ruiz A. G., Casafont F., Crespo J., Cayn A., Mayorga M., Estebanez A., Fernadez-Escalante J. C., Pons-Romero F., Lipopolysaccharide-binding protein plasma levels and liver TNF- gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis Obesity Surgery 2007 17 10 1374 1380
99. Yoshida H., Hamada T., Inuzuka S., Ueno T., Sata M., Tanikawa K., Bacterial infection in cirrhosis, with and without hepatocellular carcinoma American Journal of Gastroenterology 1993 88 12 2067 2071 (Pubitemid 23352173)
100. Deschnes M., Villeneuve J. P., Risk factors for the development of bacterial infections in hospitalized patients with cirrhosis American Journal of Gastroenterology 1999 94 8 2193 2197
101. Caly W. R., Strauss E., A prospective study of bacterial infections in patients with cirrhosis Journal of Hepatology 1993 18 3 353 358 (Pubitemid 23279724)
102. Fernndez J., Navasa M., Gmez J., Colmenero J., Vila J., Arroyo V., Rodés J., Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis Hepatology 2002 35 1 140 148 (Pubitemid 34032554)
103. Borzio M., Salerno F., Piantoni L., Cazzaniga M., Angeli P., Bissoli F., Boccia S., Colloredo-Mels G., Corigliano P., Fornaciari G., Marenco G., Pistar R., Salvagnini M., Sangiovanni A., Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study Digestive and Liver Disease 2001 33 1 41 48 (Pubitemid 32186174)
104. Campillo B., Richardet J. P., Kheo T., Dupeyron C., Nosocomial spontaneous bacterial peritonitis and bacteremia in cirrhotic patients: impact of isolate type on prognosis and characteristics of infection Clinical Infectious Diseases 2002 35 1 1 10 (Pubitemid 34666853)
105. Llovet J. M., Rodrguez-Iglesias P., Mointinho E., Planas R., Bataller R., Navasa M., Menacho M., Pardo A., Castells A., Cabré E., Arroyo V., Gassull M. A., Rodés J., Spontaneous bacterial peritonitis in patients with cirrhosis undergoing selective intestinal decontamination. A retrospective study of 229 spontaneous bacterial peritonitis episodes Journal of Hepatology 1997 26 1 88 95 (Pubitemid 27072609)
106. Campillo B., Dupeyron C., Richardet J. P., Mangeney N., Leluan G., Epidemiology of severe hospital-acquired infections in patients with liver cirrhosis: effect of long-term administration of norfloxacin Clinical Infectious Diseases 1998 26 5 1066 1070 (Pubitemid 28215464)
107. Navasa M., Rodés J., Bacterial infections in cirrhosis Liver International 2004 24 4 277 280 (Pubitemid 39162066)
108. Morencos F. C., De las Heras Castano G., Ramos L. M., Lopez Arias M. J., Ledesma F., Romero F. P., Small bowel bacterial overgrowth in patients with alcoholic cirrhosis Digestive Diseases and Sciences 1995 40 6 1252 1256
109. Bauer T. M., Steinbrckner B., Brinkmann F. E., Ditzen A. K., Schwacha H., Aponte J. J., Pelz K., Kist M., Blum H. E., Small intestinal bacterial overgrowth in patients with cirrhosis: prevalence and relation with spontaneous bacterial peritonitis American Journal of Gastroenterology 2001 96 10 2962 2967 (Pubitemid 32959540)
110. Rimola A., Bory F., Teres J., Oral, nonabsorbable antibiotics prevent infection in cirrhotics with gastrointestinal hemorrhage Hepatology 1985 5 3 463 467 (Pubitemid 15065955)
111. Soriano G., Guarner C., Tomas A., Villanueva C., Torras X., Gonzalez D., Sainz S., Anguera A., Cusso X., Balanzo J., Vilardell F., Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage Gastroenterology 1992 103 4 1267 1272
112. Gines P., Rimola A., Planas R., Vargas V., Marco F., Almela M., Forne M., Miranda M. L., Llach J., Salmeron J. M., Esteve M., Marques J. M., De Anta M. T. J., Arroyo V., Rodes J., Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: results of a double-blind, placebo-controlled trial Hepatology 1990 12 4 I 716 724 (Pubitemid 20349256)
113. Grangie J. D., Roulot D., Pelletier G., Pariente G. A., Denis J., Ink O., Blanc P., Richardet J. P., Vinel J. P., Delisle F., Fischer D., Flahault A., Amiot X., Norfloxacin primary prophylaxis of bacterial infections in cirrhotic patients with ascites: a double-blind randomized trial Journal of Hepatology 1998 29 3 430 436 (Pubitemid 28396660)
114. Groszmann R. J., Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences Hepatology 1994 20 5 1359 1363 (Pubitemid 24323589)
115. Wiest R., Groszmann R. J., The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough Hepatology 2002 35 2 478 491 (Pubitemid 34110432)
116. Vallance P., Moncada S., Hyperdynamic circulation in cirrhosis: a role for nitric oxide? The Lancet 1991 337 8744 776 778
117. Guarner C., Soriano G., Tomas A., Bulbena O., Novella M. T., Balanzo J., Vilardell F., Mourelle M., Moncada S., Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia Hepatology 1993 18 5 1139 1143 (Pubitemid 23320445)
118. Chu C. J., Lee F. Y., Wang S. S., Lu R. H., Tsai Y. T., Lin H. C., Hou M. C., Chan C. C., Lee S. D., Hyperdynamic circulation of cirrhotic rats with ascites: role of endotoxin, tumour necrosis factor- and nitric oxide Clinical Science 1997 93 3 219 225
119. Lopez-Talavera J. C., Cadelina G., Olchowski J., Merrill W., Groszmann R. J., Thalidomide inhibits tumor necrosis factor, decreases nitric oxide synthesis, and ameliorates the hyperdynamic circulatory syndrome in portal-hypertensive rats Hepatology 1996 23 6 1616 1621
120. Rasaratnam B., Kaye D., Jennings G., Dudley F., Chin-Dusting J. P. F., The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. A randomized trial Annals of Internal Medicine 2003 139 3 186 193
121. Thalhieimer U., Triantes C. K., Samonakis D. N., Patch D., Burroughs A. K., Infection, coagulation, and variceal bleeding in cirrhosis Gut 2005 54 4 556 563 (Pubitemid 40395508)
122. Goulis J., Patch D., Burroughs A. K., Bacterial infection in the pathogenesis of variceal bleeding The Lancet 1999 353 9147 139 142 (Pubitemid 29088094)
123. Montalto P., Vlachogiannakos J., Cox D. J., Pastacaldi S., Patch D., Burroughs A. K., Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study Journal of Hepatology 2002 37 4 463 470
124. Plessier A., Denninger M. H., Consigny Y., Pessione F., Francoz C., Durand F., Francque S., Bezeaud A., Chauvelot-Moachon L., Lebrec D., Valla D. C., Moreau R., Coagulation disorders in patients with cirrhosis and severe sepsis Liver International 2003 23 6 440 448 (Pubitemid 37540983)
125. Zhao C., Chen S. B., Zhou J. P., Xiao W., Fan H. G., Wu X. W., Feng G. X., He W. X., Prognosis of hepatic cirrhosis patients with esophageal or gastric variceal hemorrhage: multivariate analysis Hepatobiliary and Pancreatic Diseases International 2002 1 3 416 419 (Pubitemid 36748777)
126. Pohl J., Pollmann K., Sauer P., Ring A., Stremmel W., Schlenker T., Antibiotic prophylaxis after variceal hemorrhage reduces incidence of early rebleeding Hepato-Gastroenterology 2004 51 56 541 546 (Pubitemid 38445311)
127. Vivas S., Rodriguez M., Palacio M. A., Linares A., Alonso J. L., Rodrigo L., Presence of bacterial infection in bleeding cirrhotic patients is independently associated with early mortality and failure to control bleeding Digestive Diseases and Sciences 2001 46 12 2752 2757 (Pubitemid 33141047)
128. Blei A. T., Crdoba J., Hepatic encephalopathy American Journal of Gastroenterology 2001 96 7 1968 1976 (Pubitemid 32660887)
129. Lemberg A., Fernndez M. A., Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress Annals of Hepatology 2009 8 2 95 102
130. Yurdaydin C., Walsh T. J., Engler H. D., Ha J. H., Li Y., Jones E. A., Basile A. S., Gut bacteria provide precursors of benzodiazepine receptor ligands in a rat model of hepatic encephalopathy Brain Research 1995 679 1 42 48
131. Schafer D. F., Fowler J. M., Jones E. A., Colonic bacteria: a source of -aminobutyric acid in blood Proceedings of the Society for Experimental Biology and Medicine 1981 167 3 301 303 (Pubitemid 11049731)
132. Avallone R., Zeneroli M. L., Venturini I., Corsi L., Schreier P., Kleinschnitz M., Ferrarese C., Farina F., Baraldi C., Pecora N., Frigo M., Baraldi M., Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of patients with liver cirrhosis with and without overt encephalopathy Gut 1998 42 6 861 867 (Pubitemid 28277230)
133. Mullen K. D., Szauter K. M., Kaminsky-Russ K., Endogenous benzodiazepine activity in body fluids of patients with hepatic encephalopathy The Lancet 1990 336 8707 81 83 (Pubitemid 20222808)
134. Leger L., Lenriot J. P., Fourestier M., Goiffon B., The role of total colectomy in portacaval encephalopathy Journal de Chirurgie 1972 103 5 437 450
135. McDermott W. V., Victor M., Point W. W., Exclusion of the colon in the
136. Chapman M. L., Janowitz H. D., Chronic portal-systemic encephalopathy after ileostomy and colonic resection The Lancet 1966 1 7446 1064 1065
137. Rabiller A., Nunes H., Lebrec D., Tazi K. A., Wartski M., Dulmet E., Libert J. M., Mougeot C., Moreau R., Mazmanian M., Humbert M., Hervé P., Prevention of Gram-negative translocation reduces the severity of hepatopulmonary syndrome American Journal of Respiratory and Critical Care Medicine 2002 166 4 514 517
138. Guarner C., Runyon B. A., Heck M., Young S., Sheikh M. Y., Effect of long-term trimethoprim-sulfamethoxazole prophylaxis on ascites formation, bacterial translocation, spontaneous bacterial peritonitis, and survival in cirrhotic rats Digestive Diseases and Sciences 1999 44 10 1957 1962 (Pubitemid 29510802)
139. Runyon B. A., Borzio M., Young S., Squier S. U., Guarner C., Runyon M. A., Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis Hepatology 1995 21 6 1719 1724
140. Novella M., Sol R., Soriano G., Andreu M., Gana J., Ortiz J., Coll S., Sbat M., Vila M. C., Guarner C., Vilardell F., Continuous versus inpatient prophylaxis of the first episode of spontaneous bacterial peritonitis with norfloxacin Hepatology 1997 25 3 532 536 (Pubitemid 27106428)
141. Campillo B., Dupeyron C., Richardet J. P., Epidemiology of hospital-acquired infections in cirrhotic patients: effect of carriage of methicillin-resistant Staphylococcus aureus and influence of previous antibiotic therapy and norfloxacin prophylaxis Epidemiology and Infection 2001 127 3 443 450 (Pubitemid 34092790)
142. Gorbach S. L., Probiotics and gastrointestinal health American Journal of Gastroenterology 2000 95 1 S2 S4 (Pubitemid 30039349)
143. Mattar A. F., Drongowski R. A., Coran A. G., Harmon C. M., Effect of probiotics on enterocyte bacterial translocation in vitro Pediatric Surgery International 2001 17 4 265 268 (Pubitemid 32487929)
144. Wiest R., Chen F., Cadelina G., Groszmann R. J., Garcia-Tsao G., Effect of Lactobacillus-fermented diets on bacterial translocation and intestinal flora in experimental prehepatic portal hypertension Digestive Diseases and Sciences 2003 48 6 1136 1141 (Pubitemid 36667839)
145. Bauer T. M., Fernndez J., Navasa M., Vila J., Rodés J., Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis Journal of Hepatology 2002 36 4 501 506 (Pubitemid 34407338)
146. Forsyth C. B., Farhadi A., Jakate S. M., Tang Y., Shaikh M., Keshavarzian A., Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis Alcohol 2009 43 2 163 172
147. Chiva M., Soriano G., Rochat I., Peralta C., Rochat F., Llovet T., Mirelis B., Schiffrin E. J., Guarner C., Balanz J., Effect of Lactobacillus johnsonii La1 and antioxidants on intestinal flora and bacterial translocation in rats with experimental cirrhosis Journal of Hepatology 2002 37 4 456 462
148. Li Z., Yang S., Lin H., Huang J., Watkins P. A., Moser A. B., DeSimone C., Song X. Y., Diehl A. M., Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 2003 37 2 343 350 (Pubitemid 36152533)
149. Xu R., Wan Y., Fang Q., Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model Journal of Clinical Biochemistry and Nutrition 2012 50 1 72 77
150. Ma X., Hua J., Li Z., Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells Journal of Hepatology 2008 49 5 821 830
151. Esposito E., Iacono A., Bianco G., Autore G., Cuzzocrea S., Vajro P., Canani R. B., Calignano A., Raso G. M., Meli R., Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats Journal of Nutrition 2009 139 5 905 911
152. Velayudham A., Dolganiuc A., Ellis M., Petrasek J., Kodys K., Mandrekar P., Szabo G., VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice Hepatology 2009 49 3 989 997
153. Loguercio C., Federico A., Tuccillo C., Terracciano F., D'Auria M. V., De Simone C., Del Vecchio Blanco C., Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases Journal of Clinical Gastroenterology 2005 39 6 540 543 (Pubitemid 40863651)
154. Lata J., Novotn I., Pbramsk V., Jurnkov J., Fri P., Kroupa R., Stibrek O., The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: results of a double-blind randomized study European Journal of Gastroenterology and Hepatology 2007 19 12 1111 1113 (Pubitemid 350125383)
155. Liu Q., Duan Z. P., Ha D. K., Bengmark S., Kurtovic J., Riordan S. M., Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis Hepatology 2004 39 5 1441 1449 (Pubitemid 38569067)
156. Pereg D., Kotliroff A., Gadoth N., Hadary R., Lishner M., Kitay-Cohen Y., Probiotics for patients with compensated liver cirrhosis: a double-blind placebo-controlled study Nutrition 2011 27 2 177 181
157. Rayes N., Seehofer D., Hansen S., Boucsein K., Mller A. R., Serke S., Bengmark S., Neuhaus P., Early enteral supply of Lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients Transplantation 2002 74 1 123 127
158. Rayes N., Seehofer D., Theruvath T., Schiller R. A., Langrehr J. M., Jonas S., Bengmark S., Neuhaus P., Supply of pre- and probiotics reduces bacterial infection rates after liver transplantationa randomized, double-blind trial American Journal of Transplantation 2005 5 1 125 130 (Pubitemid 40095136)
159. Chen C., Li L., Wu Z., Chen H., Fu S., Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis Journal of Infection 2007 54 1 98 102 (Pubitemid 44932936)
160. Kummel K. F., Brokx S., Lactitol as a functional prebiotic Cereal Foods World 2001 46 9 424 429 (Pubitemid 33703784)
161. Riggio O., Varriale M., Testore G. P., Di Rosa R., Di Rosa E., Merli M., Romiti A., Candiani C., Capocaccia L., Effect of lactitol and lactulose administration on the fecal flora in cirrhotic patients Journal of Clinical Gastroenterology 1990 12 4 433 436 (Pubitemid 20234375)
162. Foster K. J., Lin S., Turck C. J., Current and emerging strategies for treating hepatic encephalopathy Critical Care Nursing Clinics of North America 2010 22 3 341 350
163. Loguercio C., Abbiati R., Rinaldi M., Romano A., Del Vecchio Blanco C., Coltorti M., Long-term effects of Enterococcus faecium SF68 versus lactulose in the treatment of patients with cirrhosis and grade 1-2 hepatic encephalopathy Journal of Hepatology 1995 23 1 39 46
164. Malaguarnera M., Greco F., Barone G., Gargante M. P., Malaguarnera M., Toscano M. A., Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study Digestive Diseases and Sciences 2007 52 11 3259 3265 (Pubitemid 47512537)
165. Bajaj J. S., Saeian K., Christensen K. M., Hafeezullah M., Varma R. R., Franco J., Pleuss J. A., Krakower G., Hoffmann R. G., Binion D. G., Probiotic yogurt for the treatment of minimal hepatic encephalopathy American Journal of Gastroenterology 2008 103 7 1707 1715
166. Mittal V. V., Sharma B. C., Sharma P., Sarin S. K., A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy European Journal of Gastroenterology and Hepatology 2011 23 8 725 732