Effect of alcohol consumption on the gut

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 17, Issue 4, 2003, Pages 575-592

  Bode, Christiane ^a   Bode, J Christian ^b,c  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b ROBERT BOSCH HOSPITAL   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Alcohol; Alcohol metabolism; Alcoholic liver disease; Bacterial overgrowth (small intestine); Cytokines; Endotoxin; Ethanol; Gut associated immune system; Intestinal absorption; Intestinal mucosa; Intestinal permeability; Mucosal injury

Indexed keywords

ALCOHOL; BACTERIAL TOXIN; ENDOTOXIN; SODIUM; VITAMIN; WATER; ALCOHOL DEHYDROGENASE; AMINO ACID; CARBOHYDRATE; DISACCHARIDE; FAT; GAMMA GLUTAMYLTRANSFERASE; MONOSACCHARIDE; PROTEIN; TRACE ELEMENT;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ALCOHOLIC BEVERAGE; ALCOHOLISM; BACTERIAL OVERGROWTH; DIARRHEA; DRINKING BEHAVIOR; DUODENUM BLEEDING; GASTROINTESTINAL DISEASE; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HUMAN; INHIBITION KINETICS; INTESTINE ABSORPTION; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE ULCER; JEJUNUM DISEASE; LIVER INJURY; MACROMOLECULE; MORPHOLOGY; MUCOSAL IMMUNITY; NUTRIENT; PORTAL VEIN BLOOD FLOW; REVIEW; SODIUM ABSORPTION; WATER ABSORPTION; ALPHA TOCOPHEROL DEFICIENCY; ASCORBIC ACID DEFICIENCY; BACTERIAL GROWTH; CYANOCOBALAMIN DEFICIENCY; DUODENUM DISEASE; FOLIC ACID DEFICIENCY; GASTROINTESTINAL HEMORRHAGE; HYPOMAGNESEMIA; IMMUNE SYSTEM; INTESTINE CELL; INTESTINE INJURY; MACRONUTRIENT; NONHUMAN; NUTRIENT UPTAKE; PYRIDOXINE DEFICIENCY; RETINOL DEFICIENCY; THIAMINE DEFICIENCY; VITAMIN D DEFICIENCY; VITAMIN INTAKE; VITAMIN K DEFICIENCY;

ALCOHOL DRINKING; ALCOHOLIC BEVERAGES; ALCOHOLISM; ANIMALS; ETHANOL; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALNUTRITION; PERMEABILITY;

EID: 0347353495     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6918(03)00034-9     Document Type: Review

References (81)

1. Bode J.C. Bode C. Alcohol malnutrition and the gastrointestinal tract. In Watson R.R. Watzl B. (Eds.), Nutrition and Alcohol 1990 403-428 CRC Press Boca Raton, FL
2. Mezey E. Effect of ethanol on intestinal morphology, metabolism, and function. In Seitz H.K. Kommerell B. (Eds.), Alcohol Related Diseases in Gastroentreology 1985 342-360 Springer Berlin
3. Bode J.C. Parlesak A. Bode C. Gut-derived bacterial toxins (endotoxin) and alcoholic liver disease. In Agarwal D.P. Seitz H.K. (Eds.), Alcohol in Health and Disease 2001 369-386 Marcel Dekker New York, Basel
4. Salaspuro M. Alcohol metabolism by gut flora. Metabolic, pathogenetic, and clinical implications. In Agarwal D.P. Seitz H.K. (Eds.), Alcohol in Health and Disease 2001 67-85 Marcel Dekker New York, Basel
5. Jerells T.R. Pruett S.B. Immunotoxic effects of ethanol. In Dean J.H. Luster M.I. Munson A.E. Kimber I. (Eds.), Immunotoxicology and Immunopharmacology 2nd edn 1994 323-347 Raven Press New York
6. Hüllinghorst R. Alkoholkonsum - Zahlen und Fakten. In Singer M.V. Teyssen S. (Eds.), Alkohol und Alkoholfolgekrankheiten 1999 32-39 Springer Berlin
7. Bode J.C. Alcohol and the gastrointestinal tract Advances in Internal Medicine and Pediatrics 45 1980 1-75
8. Ammon E. Schäfer C. Hofmann U. Klotz U. Disposition and first-pass metabolism of ethanol in humans: is it gastric or hepatic and does it depend on gender? Clinical Pharmacology and Therapy 59 1996 503-513
9. Gentry R.T. Baraona E. Lieber C.S. Agonist: gastric first pass metabolism of alcohol Journal of Laboratory and Clinical Medicine 123 1994 21-26
10. Levitt M.D. Antagonist: the case against first-pass metabolism of ethanol in the stomach Journal of Laboratory and Clinical Medicine 123 1994 28-31
11. Pestalozzi D.M. Bühler R. von Wartburg J.P. Hess M. Immunohistochemical localization of alcohol dehydrogenase in the human gastrointestinal tract Gastroenterology 85 1983 1011-1016
12. Seitz H.K. Egerer G. Oneta C. et al. Alcohol dehydrogenase in the human colon and rectum Digestion 57 1996 105-108
13. Salaspuro M. Bacteriocolonic pathway for ethanol oxidation: characteristics and implications Annals of Medicine 28 1996 195-200
14. Beck I.T. Dinda P.K. Acute exposure of small intestine to ethanol. Effects on morphology and function Digestive Disease and Sciences 26 1981 817-838
15. Thomson A.B.R. Acute exposure of rabbit jejunum to ethanol. In vitro uptake of hexoses Digestive Diseases and Sciences 29 1984 267-274
16. Hayashi H. Nakata K. Motohashi Y. Takano T. Acute inhibition of lipid transport in rat intestinal lymph by ethanol administration Alcohol & Alcoholism 27 1992 627-632
17. Hajjar J.J. Tomicic T. Scheig R.L. Effect of chronic ethanol consumption on leucine absorption in the rat small intestine Digestion 22 1981 170-176
18. Martines D. Morris A.I. Billington D. The effect of chronic ethanol intake on leucine absorption from the rat small intestine Alcohol and Alcoholism 24 1989 525-531
19. Roggin G.M. Iber F.L. Kater R.M. Tabon F. Malabsorption in the chronic alcoholic Johns' Hopkins Medical Journal 125 1969 321-330
20. Dinda P.K. Beck I.T. Effects of ethanol on cytoplasmic peptidases of the jejunal epithelial cell of the hamster Digestive Diseases and Sciences 29 1984 46-55
21. Pfeiffer A. Schmidt T. Vidon N. et al. Absorption of a nutrient solution in chronic alcoholics without nutrient deficiencies and liver cirrhosis Scandinavian Journal of Gastroenterology 27 1992 1023-1030
22. Halsted C.H. Keen C.L. Alcoholism and micronutrient metabolism and deficiencies European Journal of Gastroenterology and Hepatology 6 1990 399-402
23. 12 deficiencies in alcoholism Seminars in Haematology 17 1980 119-129
24. Baines M. Bligh J.G. Madden J.S. Tissue thiamin levels of hospitalised alcoholics before and after oral or parenteral vitamins Alcohol and Alcoholism 23 1988 49-52
25. Thomson A.D. Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome Alcohol and Alcoholism 35 2000 2-7
26. Hoyumpa A.M.Jr. Breen K.J. Schenker S. Wilson F.A. Thiamine transport across the rat intestine. II. Effect of ethanol Journal of Laboratory and Clinical Medicine 86 1975 803-816
27. Tallaksen C.M. Bell H. Bohmer T. The concentration of thiamin and thiamin phosphate esters in patients with alcoholic liver cirrhosis Alcohol and Alcoholism 27 1992 523-530
28. Lieber C.S. The influence of alcohol on nutritional status Nutritional Revue 46 1988 241-254
29. Bujanda L. The effects of alcohol consumption upon the gastrointestinal tract American Journal of Gastroenterology 95 2000 3374-3382
30. McClain C.J. Kasarskis E.J. Marsano L. Zinc and alcohol. In Watson R.R. Watzl B. (Eds.), Nutrition and Alcohol 1990 281-297 CRC Press Boca Raton, FL
31. Adams P.C. Iron overload in viral and alcoholic liver disease Journal of Hepatology 28 1998 19-20
32. Persson J. Alcohol and the small intestine Scandinavian Journal of Gastroenterology 26 1991 3-15
33. Duane P. Raja K.B. Simpson R.J. Peters T.J. Intestinal iron absorption in chronic alcoholics Alcohol and Alcoholism 27 1992 539-544
34. Dworkin B.M. Rosenthal W.S. Stahl R.E. Panesar N.K. Decreased hepatic selenium content in alcoholic cirrhosis Digestive Diseases and Sciences 33 1988 1213-1217
35. Thuluvath P.J. Triger D.R. Selenium in chronic liver disease Journal of Hepatolology 14 1992 176-182
36. Bode J.C. Knüppel H. Schwerk W. Bode C. Activities of cytoplasmic, mitochondrial and brush border enzymes in jejunal mucosa of chronic alcoholics Zeitschrift für Gastroenterologie 20 1982 228-233
37. Baraona E. Pirola R.C. Lieber C.S. Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat Gastroenterology 66 1974 226-234
38. Gottfried E.B. Korsten M.A. Lieber C.S. Alcohol-induced gastric and duodenal lesions in man American Journal of Gastroenterology 70 1978 587-592
39. Kelly J.P. Kaufman D.W. Koff R.S. et al. Alcohol consumption and the risk of major upper gastrointestinal bleeding American Journal of Gastroenterology 90 1995 1058-1064
40. Ray M. Dinda P.K. Beck I.T. Mechanism of ethanol-induced jejunal microvascular and morphologic changes in the dog Gastroenterology 96 1989 345-354
41. Dinda P.K. Kossev P. Beck I.T. Buell M.G. Role of xanthine oxidase-derived oxidants and leukocytes in ethanol-induced jejunal mucosal injury Digestive Diseases and Sciences 41 1996 2461-2470
42. Beck I.T. Boyd A. Dinda P.K. Evidence for the involment of 5-lipoxygenase products in the ethanol-induced intestinal plasma protein loss American Journal of Physiology 254 1988 483-488
43. Dinda P.K. Leddin D.J. Beck I.T. Histamine is involved in ethanol-induced jejunal microvascular injury in rabbits Gastroenterology 95 1988 1227-1233
44. Casini A. Galli A. Calabro' A. et al. Ethanol-induced alterations of matrix network in the duodenal mucosa of chronic alcohol abusers Virchows Archiv 434 1999 127-135
45. Vaquera J. Vaquera A. Girbes T. Effects of chronic administration of either ethanol or pentanol on rat duodenum morphology Histology and Histopathology 17 2002 199-203
46. Bode J.C. Bode C. Heidelbach R. et al. Jejunal microflora in patients with chronic alcohol abuse Hepatogastroenterology 30 1984 30-34
47. Bode C. Schäfer C. Bode J.C. The role of gut-derived bacterial toxins (endotoxin) for the development of alcoholic liver disease in man. In Blum H.E. Bode C. Bode J.C. Sartor R.B. (Eds.), Gut and the Liver 1998 281-298 Kluwer Dordrecht Falk Symposium 100
48. Bjarnason I. Ward K. Peters T.J. The leaky gut of alcoholism:possible route of entry for toxic compounds Lancet 1 1984 979-982
49. Parlesak A. Schäfer C. Schütz T. et al. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease Journal of Hepatology 32 2000 742-747
50. Fukui H. Brauner B. Bode J.C. Bode C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevalution with an improved chromogenic assay Journal of Hepatology 12 1991 162-169
51. Mathurin P. Deng Q.G. Keshavarzian A. et al. Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology 32 2000 1008-1017
52. McClain C. Hill D. Schmidt J. Diehl A.M. Cytokines and alcoholic liver disease Seminars in Liver Disease 13 1993 170-182
53. Adachi Y. Moore L.E. Bradford B.U. et al. Antibiotics prevent liver injury in rats following long-term exposure to ethanol Gastroenterology 108 1995 218-224
54. Nanji A.A. Khettry U. Sadrzadeh S.M. Yamanaka T. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostagladin E2, leukotrine B4, and thromboxane B2 American Journal of Pathology 142 1993 367-373
55. Ferro D. Quintarelli C. Lattuada A. et al. High plasma levels of von Willebrand factor as a marker of endothelial perturbation in cirrhosis: relationship to endotoxemia Hepatology 23 1996 1377-1383
56. Bode C. Schäfer C. Fukui H. et al. Effect of treatment with paromomycin on endotoxemia in patients with alcoholic liver disease - a double-blind, placebo-controlled trial Alcoholism, Clinical And Experimental Research 21 1997 1367-1373
57. Kolbel C.B. Singer M.V. Mohle T. et al. Action of intravenous ethanol and atropine on the secretion of gastric acid, pancreatic enzymes, and bile acids and the motility of the upper gastrointestinal tract in nonalcoholic humans Pancreas 1 1986 211-218
58. Charles F. Evans D.F. Castillo F.D. Wingate D.L. Daytime ingestion of alcohol alters nighttime jejunal motility in man Digestive Diseases and Sciences 39 1994 51-58
59. Schmidt T. Eberle R. Pfeiffer A. Kaess H. Effect of ethanol on postprandial duodenojejunal motility in humans Digestive Diseases and Sciences 42 1997 1628-1633
60. Addolorato G. Capristo E. Gasbarrini G. Stefanini G.F. Depression, alcohol abuse and orocaecal transit time Gut 41 1997 417-418
61. Wegener M. Schaffstein J. Dilger U. et al. Gastrointestinal transit of solid-liquid meal in chronic alcoholics Digestive Diseases and Sciences 36 1991 917-923
62. Lu G. Sarr M.G. Szurszewski J.H. Effects of ethyl alcohol on canine jejunal circular smooth muscle Digestive Diseases and Sciences 42 1997 2403-2410
63. Preedy V.R. Marway J.S. Siddiq T. et al. Gastrointestinal protein turnover and alcohol misuse Drug and Alcohol Dependence 34 1993 1-10
64. Bouchoucha M. Nalpas B. Berger M. et al. Recovery from disturbed colonic transit time after alcohol withdrawal Diseases of the Colon and Rectum 34 1991 111-114
65. MacGregor R.R. Alcohol and immune defense Journal of the American Medical Association 256 1986 1474-1479
66. Jerrells T.R. Peritt D. Marietta C. Eckardt M.J. Mechanisms of suppression of cellular immunity induced by ethanol Alcohol, Clinical and Experimental Research 13 1989 490-493
67. Adams H.G. Jordan C. Infections in the alcoholic Medical Clinics of North America 68 1984 179-200
68. MacGregor R.R. Louria D.B. Alcohol and infection Current Clinical Topics in Infectious Diseases 17 1997 291-315
69. Strober W. Kelsall B. et al. Mucosal immunopathology Springer Seminars in Immunopathology 18 1997 407-589
70. Bode J.C. Knüppel H. Schwerk W. et al. Quantitative histomorphometric study of the jejunal mucosa in chronic alcoholics Digestion 23 1982 265-270
71. Maier A. Bode C. Fritz P. Bode J.C. Effects of chronic alcohol abuse on duodenal mononuclear cells in man Digestive Diseases and Sciences 44 1999 691-696
72. van de Wiel A. Delacroix D.L. van Hattum J. et al. Characteristics of serum IgA and liver IgA deposits in alcoholic liver disease Hepatology 7 1987 95-99
73. Colombel J.F. Vaerman J.P. Mesnard B. et al. Jejunal immunoglobulin secretion in alcoholic patients with and without cirrhosis Journal of Hepatology 12 1991 145-149
74. Trejdosiewicz L.K. Crabtree J.E. Gastrointestinal intra-epithelial lymphocytes in man: the saga continues European Journal of Gastroenterology and Hepatology 7 1995 537-540
75. Sibley D. Jerrells T.R. Alcohol consumption by C57BL/6 mice is associated with depletion of lymphoid cells from the gut-associated lymphoid tissues and altered resistance to oral infections with Salmonella typhimurium Journal of Infectious Diseases 182 2000 482-489
76. Weisse M.E. Eberly B. Person D.A. Wine as a digestive aid: comparative antimicrobial effects of bismuth salicylate and red and white wine British Medical Journal 311 1995 1657-1660
77. Marimon J.M. Bujanda L. Gutierrez-Stampa M.A. Antibacterial activity of wine against Salmonella enteritidis: pH or alcohol? Journal of Clinical Gastroenterology 27 1998 179-180
78. Cook K.A. Mead P.S. Mintz E.D. Don't rely on drinking wine to prevent traveller's diarrhoea British Medical Journal 312 1996 642
79. Simanowski U.A. Seitz H.K. Baier B. et al. Chronic ethanol consumption selectively stimulates rectal cell proliferation in the rat Gut 27 1986 278-282
80. Simanowski U.A. Suter P. Russell R.M. Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats Gut 35 1994 1102-1106
81. Seitz H.K. Simanowski U.A. Cell turnover in the gastrointestinal tract and the effect of ethanol. In Preedy V.R. Watson R.R. (Eds.), Alcohol and the Gastrointestinal Tract 1996 273-288 CRC Press Boca Raton, New York