Infection, coagulation, and variceal bleeding in cirrhosis

Gut

Volumn 54, Issue 4, 2005, Pages 556-563

  Thalhieimer, U ^a   Triantes, C K ^a   Samonakis, D N ^a   Patch, D ^a   Burroughs, A K ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CISAPRIDE; CYTOKINE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTOXIN; HEPARAN SULFATE; NEOMYCIN; NORFLOXACIN; PROPRANOLOL; TECHNETIUM SULFUR COLLOID TC 99M;

ANTIBIOTIC THERAPY; BACTERIAL INFECTION; BACTERIAL OVERGROWTH; BACTERIAL PERITONITIS; BACTERIAL TRANSLOCATION; BLOOD CLOTTING DISORDER; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG MECHANISM; ENDOTOXEMIA; ESCHERICHIA COLI; ESOPHAGUS VARICES BLEEDING; FIBRINOLYSIS; HEMODYNAMICS; HEMOSTASIS; HEPATIC ENCEPHALOPATHY; HUMAN; INFECTION PREVENTION; INFECTION RISK; INTESTINE FLORA; INTESTINE MOTILITY; INTESTINE MUCOSA PERMEABILITY; KLEBSIELLA PNEUMONIAE; LIVER BLOOD FLOW; LIVER CIRRHOSIS; LIVER DYSFUNCTION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW; RISK FACTOR; SEPSIS; SYSTEMIC VASCULAR RESISTANCE; THROMBOCYTE AGGREGATION; THROMBOELASTOGRAPHY;

BACTERIAL INFECTIONS; BACTERIAL TRANSLOCATION; BLOOD COAGULATION DISORDERS; ENDOTOXEMIA; ESOPHAGEAL AND GASTRIC VARICES; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL MOTILITY; HEMODYNAMIC PROCESSES; HUMANS; LIVER CIRRHOSIS;

EID: 15444376944     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.048181     Document Type: Review

References (85)

1. Borzio M, Salerno F, Piantoni L, et al. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis 2001;33:41-8.
2. Rimola A, Soto R, Bory F, et al. Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis. Hepatology 1984;4:53-8.
3. Navasa M, Rimola A, Rodes J. Bacterial infections in liver disease. Semin Liver Dis 1997;17:323-33.
4. Goulis J, Armonis A, Patch D, et al. Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 1998;27:1207-12.
5. Hou MC, Lin HC, Liu TT, et al. Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial. Hepatology 2004;39:746-53.
6. Montolto P, Vlachogiannakos J, Cox DJ, et al. Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study. J Hepatol 2002;37:463-70.
7. Zambruni A, Thalheimer U, Coppell J, et al. Endogenous heparin like activity detected by anti-Xa assay in infected cirrhotic and non-cirrhotic patients. Scand J Gastroenterol 2004;39:830-6.
8. Rasaratnam B, Kaye D, Jennings G, et al. The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. A randomized trial. Ann Intern Med 2003;139:186-93.
9. Brandtzaeg P. Significance and pathogenesis of septic shock. Curr Top Microbiol Immunol 1996;216:15-37.
10. Lin RS, Lee FY, Lee SD, et al. Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation. J Hepatol 1995;22:165-72.
11. Lumsden AB, Henderson JM, Kutner MH. Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis. Hepatology 1988;8:232-6.
12. Perez-Paramo M, Munoz J, Albillos A, et al. Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites. Hepatology 2000;31:43-8.
13. Casafont F, Almohalla C, Garcia P, et al. Small bowel bacterial overgrowth in patients with alcoholic cirrhosis. Dig Dis Sci 1996;41:552-6.
14. Ramachandran A, Balasubramanian KA. Intestinal dysfunction in liver cirrhosis: Its role in spontaneous bacterial peritonitis. J Gastroenterol Hepatol 2001;16:607-12.
15. Madrid AM, Cumsille F, Defilippi C. Altered small bowel motility in patients with liver cirrhosis depends on severity of liver disease. Dig Dis Sci 1997;42:738-42.
16. Campillo B, Pernet P, Bories PN, et al. Intestinal permeability in liver cirrhosis: relationship with severe septic complications. Eur J Gastroenterol Hepatol 1999;11:755-9.
17. Fiandra R, Esposito P, deMagistris L, et al. Intestinal permeability and liver cirrhosis. Dig Liver Dis 2004;36(suppl 2):S247.
18. Wiest R, Rath HC. Gastrointestinal disorders of the critically ill. Bacterial translocation in the gut. Best Pract Res Clin Gastroenterol 2003;17:397-425.
19. Aldersley MA, Howdle PD. Intestinal permeability and liver disease. Eur J Gastroenterol Hepatol 1999;11:401-3.
20. Madrid AM, Hurtado C, Venegas M, et al. Long-term treatment with cisapride and antibiotics in liver cirrhosis: effect on small intestinal motility, bacterial overgrowth, and liver function. Am J Gastroenterol 2001;96:1251-5.
21. Chelarescu O, Chelarescu D, Tircoveanu E, et al. Propranolol administration on post surgical infections in cirrhotic patients. J Hepatol 2003;38(suppl 2):A173.
22. Hoshino S, Shinoura S, Akamine H, et al. Effect of propranolol for the prevention of spontaneous bacterial peritonitis. Am J Gastroenterol 2000;95:A349.
23. Gaulis J, Patch D, Burroughs AK. Bacterial infection in the pathogenesis of variceal bleeding. Lancet 1999;353:139-42.
24. Garcia-Tsao G. Bacterial translocation: cause or consequence of decompensation in cirrhosis? J Hepatol 2001;34:150-5.
25. Garcia-Tsao G, Lee FY, Barden GE, et al. Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites. Gastroenterology 1995;108:1835-41.
26. Garcia-Tsao G, Albillos A, Barden GE, et al. Bacterial translocation in acute and chronic portal hypertension. Hepatology 1993;17:1081-5.
27. Cirera I, Bauer TM, Navasa M, et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol 2001;34:32-7.
28. Navasa M, Follo A, Llovet JM, et al. Randomized, comparative study of oral ofloxacin versus intravenous cefotaxime in spontaneous bacterial peritonitis. Gastroenterology 1996;111:1011-17.
29. Llavet JM, Bartoli R, March F, et al. Translocated intestinal bacteria cause spontaneous bacterial peritonitis in cirrhotic rats: molecular epidemiologic evidence. J Hepatol 1998;28:307-13.
30. Frances R, Benlloch S, Zapater P, et al. A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites. Hepatology 2004;39:484-91.
31. Soares-Weiser K, Brezis M, Tur-Kaspa R, et al. Antibiotic prophylaxis of bacterial infections in cirrhotic inpatients: a meta-analysis of randomized controlled trials. Scand J Gastroenterol 2003;38:193-200.
32. Pittner RA, Spitzer JA. Endotoxin and TNF alpha directly stimulate nitric oxide formation in cultured rat hepatocytes from chronically endotoxemic rats. Biochem Biophys Res Commun 1992;185:430-5.
33. Perez DP, Pizcueta P, Engel P, et al. Enhanced monocyte activation and hepatotoxicity in response to endotoxin in portal hypertension. J Hepatol 2000;32:25-31.
34. Albillos A, Hera ADAL, Reyes E, et al. Tumour necrosis factor-alpha expression by activated monocytes and altered T-cell homeostasis in ascitic alcoholic cirrhosis: amelioration with norfloxacin. J Hepatol 2004;40:624-31.
35. Byl B, Roucloux I, Crusiaux A, et al. Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients. Gastroenterology 1993;104:1492-7.
36. Ahmod N, Gardner CR, Yurkow EJ, et al. Inhibition of macrophages with gadolinium chloride alters intercellular adhesion molecule-1 expression in the liver during acute endotoxemia in rats. Hepatology 1999;29:728-36.
37. Vaquero J, Polson J, Chung C, et al. Infection and the progression of hepatic encephalopathy in acute liver failure. Gastroenterology 2003;125:755-64.
38. Bigatello LM, Broitman SA, Fattori L, et al. Endotoxemia, encephalopathy, and mortality in cirrhotic patients. Am J Gastroenterol 1987;82:11-15.
39. Schrier RW, Arroyo V, Bernardi M, et al. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988;8:1151-7.
40. Atucha NM, Shah V, Garcia-Cardena G, et al. Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenteroolgy 1996;111:1627-32.
41. Castro A, Jimenez W, Claria J, et al. Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology 1993;18:367-72.
42. Cahill PA, Redmond EM, Hodges R, et al. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatol 1996;25:370-8.
43. Wiest R, Das S, Cadelina G, et al. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. J Clin Invest 1999;104:1223-33.
44. Sanchez-Rodriguez A, Criado M, Rodriguez-Lopez AM, et al. Increased nitric oxide synthesis and inducible nitric oxide synthase expression in patients with alcoholic and non-alcoholic liver cirrhosis. Clin Sci (Lond) 1998;94:637-43.
45. Wiest R, Cadelina G, Milstien S, et al. Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats. Hepatology 2003;38:1508-15.
46. Moreau R, Hadengue A, Soupison T, et al. Septic shock in patients with cirrhosis: hemodynamic and metabolic characteristics and intensive care unit outcome. Crit Care Med 1992;20:746-50.
47. Albillos A, de la HA, Gonzalez M, et al. Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement. Hepatology 2003;37:208-17.
48. Guarner C, Soriano G, Tomas A, et al. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 1993;18:1139-43.
49. Genesca J, Marti R, Rojo F, et al. Increased tumour necrosis factor alpha production in mesenteric lymph nodes of cirrhotic patients with ascites. Gut 2003;52:1054-9.
50. Lopez-Talavsra JC, Levitzki A, Martinez M, et al. Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites. J Clin Invest 1997;100:664-70.
51. Guarner C, Runyon BA, Heck M, et al. Effect of long-term trimethoprim-sulfamethoxazole prophylaxis on ascites formation, bacterial translocation, spontaneous bacterial peritonitis, and survival in cirrhotic rats. Dig Dis Sci 1999;44:1957-62.
52. Chin-Dusting JP, Rasaratnam B, Jennings GL, et al. Effect of fluoroquinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis. Ann Intern Med 1997;127:985-8.
53. Ruiz-del-Arbol L, Urman J, Fernandez J, et al. Systemic, renal, and hepatic hemodynamic derangement in cirrhotic patients with spontaneous bacterial peritonitis. Hepatology 2003;38:1210-18.
54. Navasa M, Follo A, Filella X, et al. Tumor necrosis factor and interleukin-6 in spontaneous bacterial peritonitis in cirrhosis: relationship with the development of renal impairment and mortality. Hepatology 1998;27:1227-32.
55. Burke GW, Cirocco R, Roth D, et al. Activated cytokine pattern in hepatorenal syndrome: fall in levels after successful orthotopic liver transplantation. Transplant Proc 1993;25:1876-7,
56. Campillo B, Bories PN, Benvenuti C, et al. Serum and urinary nitrate levels in liver cirrhosis: endotoxemia, renal function and hyperdynamic circulation. J Hepatol 1996;25:707-14.
57. Sort P, Navasa M, Arroyo V, et al. Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 1999;341:403-9.
58. Evans TW. Review article: albumin as a drug-biological effects of albumin unrelated to oncotic pressure. Aliment Pharmacol Ther 2002;16(suppl 5):6-11.
59. Follo A, Llovet JM, Navasa M, et al. Renal impairment after spontaneous bacterial peritonitis in cirrhosis: incidence, clinical course, predictive factors and prognosis. Hepatology 1994;20:1495-501.
60. Arroyo V, Jimenez W. Complications of cirrhosis. II. Renal and circulatory dysfunction. Lights and shadows in an important clinical problem. J Hepatol 2000;32(supPl 1):157-70.
61. Rockey D. The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997;25:2-5.
62. Yamamoto S, Burman HP, O'Donnell CP, et al. Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock. Am J Physiol 1997;272:H1239-49.
63. Baveja R, Keller S, Yokoyama Y, et al. LPS-induced imbalanced expression of hepatic vascular stress genes in cirrhosis: possible mechanism of increased susceptibility to endotoxemia. Shock 2002;17:316-21.
64. Pinzani M, Fallli P, Ruocco C, et al. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J Clin Invest 1992;90:642-6.
65. Chau TN, Chan YW, Patch D, et al. Thrombelastographic changes and early rebleeding in cirrhotic patients with variceol bleeding. Gut 1998;43:267-71.
66. Papatheodoridis GV, Patch D, Webster GJ, et al. Infection and hemostasis in decompensated cirrhosis: a prospective study using thrombelastography. Hepatology 1999;29:1085-90.
67. Thalheimer U, Triantos C, Samonakis D, et al. Endogenous heparinoids in acute variceol bleeding. Gut 2005;54:310-11.
68. McKee RF, Hodson S, Dawes J, et al. Plasma concentrations of endogenous heparinoids in portal hypertension. Gut 1992;33:1549-52.
69. Vincent JL, Yagushi A, Pradier O. Platelet function in sepsis. Crit Care Med 2002;30(suppl 5):S313-17.
70. Grignani G, Maiolo A. Cytokines and hemostasis. Haemotologica 2000;85:967-72.
71. Amitrano L, Guardascione MA, Brancaccio V, et al. Coagulation disorders in liver disease. Semin Liver Dis 2002;22:83-96.
72. Bertaglia E, Belmonte P, Vertolli U, et al. Bleeding in cirrhotic patients: a precipitating factor due to intravascular coagulation or to hepatic failure? Haemostasia 1983;13:328-34.
73. Ben Ari Z, Osman E, Hutton RA, et al. Disseminated intravascular coagulation in liver cirrhosis: fact or fiction? Am J Gastroenterol 1999;94:2977-82.
74. Violi F, Ferro D, Basili S, et al. Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis. Gastroenterology 1995;109:531-9.
75. Plessier A, Denninger M, Durand F, et al. Marked decreases in protein C and antithrombin III activities in patients with cirrhosis and severe sepsis. J Hepatol 2002;36(suppl 1):A628.
76. Han DW. Intestinal endotoxemia as a pathogenetic mechanism in liver failure. World J Gastroenterol 2002;8:961-5.
77. Hewett JA, Schultze AE, VanCise S, et al. Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab Invest 1992;66:347-61.
78. Ogushi I, Iimuro Y, Seki E, et al. Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatalogy 2003;38:335-44.
79. Thurman RG, Bradford BU, Iimuro Y, et al. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. J Gastroenterol Hepatol 1998;13(suppl):S39-50.
80. Adachi Y, Moore LE, Bradford BU, et al. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995;108:218-24.
81. Coral G, Mattos A, Valiatti F, et al. Bacterial infections in cirrhotic patients. J Hepatol 2002;36(suppl 1):A709.
82. Benavides J, Fernandez N, Colomboto L, et al. Further evidence linking, bacterial infection and upper G.I. bleeding in cirrhosis. Results from a large multicentric prospective survey in Argentina. J Hepatol 2003;38(suppl 2):A176.
83. Vivas S, Rodriguez M, Palacio MA, et al. Presence of bacterial infection in bleeding cirrhotic patients is independently associated with early mortality and failure to control bleeding. Dig Dis Sci 2001;46:2752-7.
84. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 1988;319:983-9.
85. Janssen HL, Wijnhoud A, Haagsma EB, et al. Extrahepatic portal vein thrombosis: aetiology and determinants of survival. Gut 2001;49:720-4.