"good enough solutions" and the genetics of complex diseases

Circulation Research

Volumn 111, Issue 4, 2012, Pages 493-504

  Weiss, James N ^a,b   Karma, Alain ^g   MacLellan, W Robb ^a,b   Deng, Mario ^a   Rau, Christoph D ^c   Rees, Colin M ^g   Wang, Jessica ^a   Wisniewski, Nicholas ^a   Eskin, Eleazar ^f   Horvath, Steve ^c   Qu, Zhilin ^a   Wang, Yibin ^a,b,e   Lusis, Aldons J ^a,c,d  

^a Departments of Medicine (Cardiology)   (United States)

^b Departments of Physiology   (United States)

^c Departments of Human Genetics   (United States)

^d Departments of Microbiology Immunology and Molecular Genetics ^*  (United States)

^e Institute of Molecular Medicine   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g NORTHEASTERN UNIVERSITY   (United States)

Author keywords

computational biology; genetics of complex diseases; hybrid mouse diversity panel; scale free networks; systems genetics

Indexed keywords

DISEASE PREDISPOSITION; DRUG SENSITIVITY; ENVIRONMENTAL STRESS; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC VARIABILITY; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; DATABASES, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; INHERITANCE PATTERNS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SYSTEMS BIOLOGY;

EID: 84864884509     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.269084     Document Type: Review

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