Autophagy is active in normal colon mucosa

Autophagy

Volumn 8, Issue 6, 2012, Pages 893-902

  Groulx, Jean François ^a   Khalfaoui, Taoufik ^a   Benoit, Yannick D ^a   Bernatchez, Gérald ^a   Carrier, Julie C ^a   Basora, Nuria ^a   Beaulieu, Jean Franco̧is ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Autophagy; BECN1; Cancer; Colon; Epithelium; p62 SQSTM1

Indexed keywords

ADULT; AGED; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE;

EID: 84864884496     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.19738     Document Type: Article

References (54)

1. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-77; PMID:15068787; http://dx.doi.org/10.1016/S1534-5807(04)00099-1
2. Klionsky DJ, Cregg JM, Dunn WA, Jr., Emr SD, Sakai Y, Sandoval IV, et al. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5:539-45; PMID:14536056; http://dx.doi.org/10.1016/S1534-5807(03)00296-X
3. Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9: 1102-9; PMID:17909521; http://dx.doi.org/10. 1038/ncb1007-1102
4. Cao Y, Klionsky DJ. Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res 2007; 17:839-49; PMID:17893711; http://dx.doi.org/10.1038/cr.2007.78
5. Mehrpour M, Esclatine A, Beau I, Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res 2010; 20:748-62; PMID:20548331; http://dx.doi.org/10.1038/cr.2010.82
6. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4:151-75; PMID: 18188003
7. Ichimura Y, Kominami E, Tanaka K, Komatsu M. Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy 2008; 4:1063-6; PMID:18776737
8. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137:1062- 75; PMID:19524509; http://dx.doi.org/10.1016/j.cell.2009.03.048
9. Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am J Pathol 2002; 160:255-63; PMID:11786419; http://dx.doi.org/10.1016/S0002-9440(10)64369-6
10. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75; PMID:18305538; http://dx.doi.org/10.1038/nature06639
11. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-5; PMID:15528435; http://dx.doi.org/10.1126/ science.1099993
12. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-63; PMID: 18849966; http://dx.doi.org/10. 1038/nature07416
13. Klionsky DJ. Crohn's disease, autophagy, and the Paneth cell.NEngl J Med 2009; 360:1785-6;PMID:19369659; http://dx.doi.org/10.1056/NEJMcibr0810347
14. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112:1809-20; PMID:14638851
15. Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003; 100:15077-82; PMID:14657337; http://dx.doi.org/10.1073/pnas.2436255100
16. Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, et al. Cloning and genomic organization ofbeclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999; 59:59-65; PMID: 10395800; http://dx.doi.org/10. 1006/geno.1999.5851
17. Gao X, Zacharek A, Salkowski A, Grignon DJ, Sakr W, Porter AT, et al. Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res 1995; 55:1002-5; PMID:7866981
18. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672-6; PMID:10604474; http://dx.doi.org/10.1038/45257
19. Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, et al. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009; 5:303-6; PMID:19066461; http://dx.doi.org/10.4161/auto.5.3.7491
20. Sato K, Tsuchihara K, Fujii S, Sugiyama M, Goya T, Atomi Y, et al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res 2007; 67:9677-84; PMID: 17942897; http://dx.doi.org/10.1158/0008-5472.CAN-07-1462
21. Yoshioka A, Miyata H, Doki Y, Yamasaki M, Sohma I, Gotoh K, et al. LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol 2008; 33:461-8; PMID:18695874
22. Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, Kim SS, et al. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 2007; 115:1344-9; PMID:18184403; http://dx.doi.org/10.1111/j.1600-0463.2007. 00858.x
23. Houri JJ, Ogier-Denis E, Trugnan G, Codogno P. Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells. Biochem Biophys Res Commun 1993; 197:805-11; PMID:8267619; http://dx.doi.org/10.1006/bbrc.1993.2550
24. Benoit YD, Paré F, Francoeur C, Jean D, Tremblay E, Boudreau F, et al. Cooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line. Am J Physiol Gastrointest Liver Physiol 2010; 298:G504-17; PMID:20133952; http://dx.doi.org/10.1152/ajpgi.00265.2009
25. Liang C, Feng P, Ku B, Oh BH, Jung JU. UVRAG: a new player in autophagy and tumor cell growth. Autophagy 2007; 3:69-71; PMID:17106237
26. Dydensborg AB, Teller IC, Groulx JF, Basora N, ParéF, Herring E, et al. Integrin alpha6Bbeta4 inhibits colon cancer cell proliferation and c-Myc activity. BMC Cancer 2009; 9:223; PMID:19586553; http://dx.doi.org/10.1186/1471- 2407-9-223
27. Tanida I, Ueno T, Kominami E. LC3 and Autophagy. Methods Mol Biol 2008; 445:77-88; PMID: 18425443; http://dx.doi.org/10.1007/978-1-59745-157-4-4
28. van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology 2009; 137: 15-7; PMID:19450592; http://dx.doi.org/10.1053/j.gastro.2009.05.035
29. Liu W, Liu Y, Zhu J, Wright E, Ding I, Rodgers GP. Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma. Clin Cancer Res 2008; 14:1041-9; PMID:18281536; http://dx.doi.org/10.1158/1078-0432. CCR-07-4125
30. Besson D, Pavageau AH, Valo I, Bourreau A, Bélanger A, Eymerit-Morin C, et al. A quantitative proteomic approach of the different stages of colorectal cancer establishes OLFM4 as a new nonmetastatic tumor marker. Mol Cell Proteomics 2011; 10:M111.009712; PMID:21986994; http://dx.doi.org/10.1074/mcp.M111.009712
31. Sivridis E, Koukourakis MI, Zois CE, Ledaki I, Ferguson DJ, Harris AL, et al. LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol 2010; 176:2477-89; PMID:20382705; http://dx.doi.org/10.2353/ajpath.2010.090049
32. Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12:823-30; PMID:20811354; http://dx.doi.org/10.1038/ncb0910-823
33. Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12:814-22; PMID: 20811353; http://dx.doi.org/10.1038/ncb0910-814
34. Santos RX, Cardoso S, Correia S, Carvalho C, Santos MS, Moreira PI. Targeting autophagy in the brain: a promising approach? Cent Nerv Syst Agents Med Chem 2010; 10:158-68; PMID:20518730
35. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434:843-50; PMID:15829953; http://dx.doi.org/10.1038/nature03319
36. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34; PMID: 16148885; http://dx.doi.org/10.1038/nrc1692
37. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21:1367-81; PMID:17510285; http://dx.doi.org/10.1101/gad.1545107
38. Korolchuk VI, Mansilla A, Menzies FM, Rubinsztein DC. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 2009; 33:517-27; PMID:19250912; http://dx.doi.org/10.1016/j.molcel. 2009.01.021
39. Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol 2010; 12:781-90; PMID:20639871; http://dx.doi.org/10.1038/ncb2082
40. Edelblum KL, Yan F, Yamaoka T, Polk DB. Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis 2006; 12:413-24; PMID:16670531; http://dx.doi.org/10.1097/01.MIB.0000217334.30689.3e
41. Sun Q, Fan W, Zhong Q. Regulation of Beclin 1 in autophagy. Autophagy 2009; 5:713-6; PMID: 19372752; http://dx.doi.org/10.4161/auto.5.5.8524
42. Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4:600-6; PMID:18497563
43. Knævelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA, et al. UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. Autophagy 2010; 6:863-70; PMID:20724836; http://dx.doi.org/10.4161/auto.6.7.13033
44. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62:10-29; PMID: 22237781; http://dx.doi.org/10.3322/caac.20138
45. Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol 2010; 12:665-75; PMID:20543840; http://dx.doi.org/10.1038/ncb2069
46. Koukourakis MI, Giatromanolaki A, Sivridis E, Pitiakoudis M, Gatter KC, Harris AL. Beclin 1 overand underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. Br J Cancer 2010; 103:1209-14; PMID:20842118; http://dx.doi.org/10.1038/sj.bjc.6605904
47. Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, et al. Autophagy mediates the mitotic senescence transition. Genes Dev 2009; 23: 798-803; PMID:19279323; http://dx.doi.org/10.1101/gad.519709
48. Pardo R, Lo Ré A, Archange C, Ropolo A, Papademetrio DL, Gonzalez CD, et al. Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells. Pancreatology 2010; 10:19-26; PMID:20299819; http://dx.doi.org/10.1159/000264680
49. Perreault N, Beaulieu JF. Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures. Exp Cell Res 1996; 224:354-64; PMID:8612712; http://dx.doi.org/10.1006/excr.1996.0145
50. Teller IC, Auclair J, Herring E, Gauthier R, Ménard D, Beaulieu JF. Laminins in the developing and adult human small intestine: relation with the functional absorptive unit. Dev Dyn 2007; 236:1980-90; PMID: 17503455; http://dx.doi.org/10.1002/dvdy.21186
51. Gagné D, Groulx JF, Benoit YD, Basora N, Herring E, Vachon PH, et al. Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. J Cell Physiol 2010; 222:387-400; PMID:19885839; http://dx.doi.org/10.1002/jcp.21963
52. Francoeur C, Bouatrouss Y, Seltana A, Pinchuk IV, Vachon PH, Powell DW, et al. Degeneration of the pericryptal myofibroblast sheath by proinflammatory cytokines in inflammatory bowel diseases. Gastroenterology 2009; 136:268-77, e3; PMID:18976656; http://dx.doi.org/10.1053/j.gastro.2008.10.014
53. Dydensborg AB, Herring E, Auclair J, Tremblay E, Beaulieu JF. Normalizing genes for quantitative RT-PCR in differentiating human intestinal epithelial cells and adenocarcinomas of the colon. Am J Physiol Gastrointest Liver Physiol 2006; 290:G1067-74; PMID:16399877; http://dx.doi.org/10.1152/ajpgi.00234.2005
54. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45; PMID:11328886; http://dx.doi.org/10.1093/nar/29.9.e45