BCLAF1 is a radiation-induced H2AX-interacting partner involved in cH2AX-mediated regulation of apoptosis and DNA repair

Cell Death and Disease

Volumn 3, Issue 7, 2012, Pages

  Lee, Y Y ^a   Yu, Y B ^a,b,c   Gunawardena, H P ^a,b   Xie, L ^a   Chen, X ^a,b,c  

^a Campus Box 7260 ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

apoptosis; cell cycle; DNA damage repair; Histone H2AX

Indexed keywords

BCL 2 ASSOCIATED TRANSCRIPTION FACTOR 1; CASPASE; CYCLIN D1; CYCLIN E; HISTONE H2AX; KU ANTIGEN; PROTEIN BAX; PROTEIN P21; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; BCLAF1 PROTEIN, HUMAN; CELL NUCLEUS ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; HISTONE; REPRESSOR PROTEIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; IRRADIATION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RADIATION DOSE; S PHASE CELL CYCLE CHECKPOINT; TUMOR CELL; BIOLOGY; CELL LINE; CELL STRAIN HEK293; DOUBLE STRANDED DNA BREAK; DRUG ANTAGONISM; GENETICS; IONIZING RADIATION; METABOLISM; RADIATION EXPOSURE; RNA INTERFERENCE;

ANTIGENS, NUCLEAR; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL LINE; COMPUTATIONAL BIOLOGY; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; G1 PHASE CELL CYCLE CHECKPOINTS; HEK293 CELLS; HISTONES; HUMANS; MITOCHONDRIA; RADIATION, IONIZING; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEINS;

EID: 84864867663     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.76     Document Type: Article

References (40)

1. Lobrich M, Jeggo P.A. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 2007; 7: 861-869.
2. Zhou H, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK et al. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiat Res 2003; 160: 512-516.
3. Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S et al. gH2AX and cancer. Nat Rev Cancer 2008; 8: 957-967.
4. Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A et al. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell 2009; 35: 228-239.
5. Chen X, Smith LM, Bradbury E.M. Site-specific mass tagging with stable isotopes in proteins for accurate and efficient protein identification. Anal Chem 2000; 72: 1134-1143.
6. Wang T, Gu S, Ronni T, Du YC, Chen X. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. J Proteome Res 2005; 4: 941-949.
7. Du Y-C, Gu S, Zhou J, Wang T, Cai H, Macinnes MA et al. The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca2/calmodulin in the ionizing radiation-induced cell cycle arrest. Mol Cell Proteomics 2006; 5: 1033-1044.
8. Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J et al. FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell 2008; 30: 86-97.
9. Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H et al. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 2009; 457: 57-62.
10. Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG et al. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 2009; 458: 591-596.
11. Liu H, Lu Z-G, Miki Y, Yoshida K. Protein kinase C {delta} induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol Cell Biol 2007; 27: 8480-8491.
12. Sarras H, Alizadeh Azami S, McPherson J.P. In search of a function for BCLAF1. Scientific World J 2010; 10: 1450-1461.
13. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genomewide expression patterns. Proc Natl Acad Sci USA 1998; 95: 14863-14868.
14. Kruse J-P, Gu W. Modes of p53 Regulation. Cell 2009; 137: 609-622.
15. Meek DW. Tumour Suppression by p53: A Role for the DNA Damage Response? Nat Rev Cancer, 2009; 9: 714-723.
16. Kasof GM, Goyal L, White E. Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. Mol Cell Biol 1999; 19: 4390-4404.
17. Haraguchi T, Holaska JM, Yamane M, Koujin T, Hashiguchi N, Mori C et al. Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy. Eur J Biochem 2004; 271: 1035-1045.
18. Oberdoerffer P, Sinclair D.A. The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol 2007; 8: 692-702.
19. Fragkos M, Jurvansuu J, Beard P. H2AX is required for cell cycle arrest via the p53/p21 pathway. Mol Cell Biol 2009; 29: 2828-2840.
20. Murray A.W. Recycling the cell cycle: cyclins revisited. Cell 2004; 116: 221-234.
21. Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND et al. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res 2008; 68: 7621-7628.
22. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009; 9: 400-414.
23. McPherson JP, Sarras H, Lemmers B, Tamblyn L, Migon E, Matysiak-Zablocki E et al. Essential role for Bclaf1 in lung development and immune system function. Cell Death Differ 2009; 16: 331-339.
24. Nishizaki M, Meyn RE, Levy LB, Atkinson EN, White RA, Roth JA et al. Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo. Clin Cancer Resh 2001; 7: 2887-2897.
25. Olive PL, Durand R.E. Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastasis Rev 1994; 13: 121-138.
26. Maity A, McKenna WG, Muschel R.J. The molecular basis for cell cycle delays following ionizing radiation: a review. Radiotherapy Oncol 1994; 31: 1-13.
27. Coqueret O. New Roles for p21 and p27 Cell-cycle Inhibitors: A Function for Each Cell Compartment? Trend Cell Biol, 2003; 13: 65-70.
28. Rogakou EP, Boon C, Redon C, Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146: 905-916.
29. Kuhne M, Riballo E, Rief N, Rothkamm K, Jeggo PA, Löbrich M et al. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res 2004; 64: 500-508.
30. Downs JA, Jackson S.P. A means to a DNA end: the many roles of K.u. Nat Rev Mol Cell Biol 2004; 5: 367-378.
31. Hakem R. DNA-damage repair; the good, the bad, and the ugly. EMBO J 2008; 27: 589-605.
32. Wang Q, Gao F, May WS, Zhang Y, Flagg T, Deng X et al. Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathway. Mol Cell 2008; 29: 488-498.
33. Mazumder S, Plesca D, Almasan A. A jekyll and hyde role of cyclin E in the genotoxic stress response: switching from cell cycle control to apoptosis regulation. Cell Cycle 2007; 6: 1437-1442.
34. Mazumder S, Gong B, Chen C, Drazba J, Buchsbaum J, Almasan A. Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells. Mol Cell Biol 2002; 22: 2398-2409.
35. Lieber M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 2010; 79: 181-211.
36. Long JC, Caceres J.F. The SR protein family of splicing factors: master regulators of gene expression. Biochem J 2009; 417: 15-27.
37. Rappsilber J, Mann M, Ishihama Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protocols 2007; 2: 1896-1906.
38. Xue Y, Yun D, Esmon A, Zou P, Zuo S, Yu Y et al. Proteomic dissection of agonist-specific TLR-mediated inflammatory responses on macrophages at subcellular resolution. J Proteome Res 2008; 7: 3180-3193.
39. Gunawardena HP, Huang Y, Kenjale R, Wang H, Xie L, Chen X et al. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in toll-like receptor 4 (TLR4)-mediated signaling. J Biol Chem 286: 10897-10910.
40. Avery-Kiejda KA, Zhang XD, Adams LJ, Scott RJ, Vojtesek B, Lane DP et al. Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin. Clin Cancer Res 2008; 14: 1659-1668.