Pathophysiology of the small airways in chronic obstructive pulmonary disease

Respiration

Volumn 84, Issue 2, 2012, Pages 89-97

  Baraldo, Simonetta ^a   Turato, Graziella ^a   Saetta, Marina ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Airway remodeling; Inflammation; Smoking

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; TOLL LIKE RECEPTOR;

AIRFLOW; AIRWAY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; EOSINOPHIL; FORCED EXPIRATORY VOLUME; HUMAN; LUNG; LUNG ALVEOLUS; LUNG FIBROSIS; LUNG FUNCTION; LUNG GAS EXCHANGE; LUNG PARENCHYMA; MACROPHAGE; MAST CELL; NEUTROPHIL; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SMOKING;

AIR POLLUTANTS; BLOOD-AIR BARRIER; BRONCHIOLES; DISEASE PROGRESSION; HUMANS; INHALATION EXPOSURE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY EMPHYSEMA; PULMONARY VENTILATION; SEVERITY OF ILLNESS INDEX; SMOKING;

EID: 84864867361     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000341382     Document Type: Review

References (52)

1. The Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2011. http://www.goldcopd. org/.
2. Hogg JC, Macklem PT, Thurlbeck WM: Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968; 278: 1355-1360.
3. Macklem PT, Mead J: Resistance of central and peripheral airways measured by a retrograde catheter. J Appl Physiol 1967; 22: 395-401.
4. Macklem PT: The physiology of small airways. Am J Respir Crit Care Med 1998; 157:S181-S183.
5. Contoli M, Bousquet J, Fabbri LM, Magnus-sen H, Rabe KF, Siafakas NM, et al: The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy 2010; 65:141-151.
6. Narayanan M, Owers-Bradley J, Beardsmore CS, Mada M, Ball I, Garipov R, et al: Alveo-larization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance. Am J Respir Crit Care Med 2012; 185: 186-191.
7. Burri PH: Postnatal development and growth; in Crystal RG, West JB (eds): The Lung: Scientific Foundations, section 4.1. New York, Raven Press, 1991, pp 677-687.
8. Thurlbeek WM: Pre-and postnatal organ development; in Chernick V, Mellins RN (eds): Basic Mechanisms of Pediatric Respiratory Disease: Cellular and Integrative. Philadelphia, Decker Inc., 1991, pp 23-25.
9. Reid L: The embryology of the lung; in de Renck AVS, Porter S (eds): Ciba Foundation: Symposium on Development of the Lung. London, Churchill, 1967, pp 109-430.
10. Plopper CG, Thurlbeck WM: Growth, ageing and adaptation; in Murray JF, Nadel JA (eds): Textbook of Respiratory Medicine. Philadelphia, WB Saunders, 1994, pp 36-49.
11. Doershuk CF, Fisher BJ, Matthews LW: Specific airway resistance from the perinatal period into adulthood. Alterations in childhood pulmonary disease. Am Rev Respir Dis 1974; 109:452-457.
12. Hogg J, Williams J, Richardson J, Macklem P, Thurlbeck W: Age as a factor in the distribution of lower-airway conductance in the pathologic anatomy of obstructive lung disease. N Engl J Med 1970; 282:1283-1287.
13. Hibbert M, Lannigan A, Raven J, Landau L, Phelan P: Gender differences in lung growth. Pediatr Pulmonol 1995; 19: 129-134.
14. Lambert MW: Accessory bronchiole-alveolar communications. J Pathol Bacteriol 1955; 70:311-314.
15. Meyrick B, Reid LM: Ultrastructure of alveolar lining and its development; in Hosdon WA (ed): Development of the Lung. Lung Biology in Health and Disease Series. New York, Marcel Dekker, 1977, pp 135-214.
16. Boyden EA: Development of the human lung; in Kelley VC (ed): Brennerman's Practice of Pediatrics, vol 4. Hagerstown, Harper and Row, 1972.
17. Frey U: Why are infants prone to wheeze? Physiological aspects of wheezing disorders in infants. Swiss Med Wkly 2001; 131: 400-406.
18. Landau LD, Lifshitz EM: Viscous fluids; in: Fluid Mechanics, ed 2. New York, Pergamon Press, 1987, pp 44-94.
19. Cosio MG, Saetta M, Agusti A: Immuno-logic aspects of chronic obstructive pulmo-nar y disease. N Engl J Med 2009; 360: 2445-2454.
20. Niewoehner DE, Klienerman J, Rice D: Pathological changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974; 291:755-758.
21. Yao H, Rahman I: Current concepts on oxi-dative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol 2011; 254: 72-85.
22. Matzinger P: Friendly and dangerous signals: is the tissue in control? Nat Immunol 2007; 8:11-13.
23. Ferhani N, Letuve S, Kozhich A, Thibaudeau O, Grandsaigne M, Maret M, et al: Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010; 181:917-927.
24. Cosio MG, Ghezzo H, Hogg JC, Corbin R, Loveland M, Dosman J, et al: The relationships between structural changes in small airways and pulmonary-function tests. N Engl J Med 1977; 298:1277-1281.
25. Saetta M, Di Stefano A, Turato G, Facchini FM, Corbino L, Mapp CE, et al: CD8+ T-lymphocytes in the peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 822-826.
26. Turato G, Zuin R, Saetta M: Pathogenesis and pathology of COPD. Respiration 2001; 68:117-128.
27. Luppi F, Franco F, Beghé B, Fabbri LM: Treatment of chronic obstructive pulmonary disease and its comorbidities. Proc Am Thorac Soc 2008; 5:848-856.
28. Cazzola M, Bettoncelli G, Sessa E, Cricelli C, Biscione G: Prevalence of comorbidities in patients with chronic obstructive pulmonary disease. Respiration 2010; 80:112-119.
29. van Eeden SF, Sin DD: Chronic obstructive pulmonary disease: a chronic systemic inf lammatory disease. Respiration 2008; 75: 224-238.
30. Rooney C, Sethi T: The epithelial cell and lung cancer: the link between chronic obstructive pulmonary disease and lung cancer. Respiration 2011; 81: 89-104.
31. Bosken CH, Hards J, Gatter K, Hogg JC: Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992; 145:911-917.
32. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 2645-2653.
33. Saetta M, Baraldo S, Corbino L, Turato G, Braccioni F, Rea F, et al: CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 711-717.
34. Majo J, Ghezzo H, Cosio MG: Lymphocyte population and apoptosis in the lungs of smokers and their relationship with emphysema. Eur Respir J 2001; 17:946-953.
35. 1. Am J Respir Crit Care Med 1997; 155: 852-857.
36. Saetta M, Turato G, Baraldo S, Zanin A, Braccioni F, Mapp CE, et al: Goblet cell hy-perplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation. Am J Respir Crit Care Med 2000; 161:1016-1021.
37. 1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. Am J Respir Crit Care Med 1996; 153: 1530-1535.
38. Montes De Oca M, Halbert RJ, Lopez MV, Perez-Padilla R, Tálamo C, Moreno D, et al: Chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study. Eur Respir J 2012, E-pub ahead of print.
39. Baraldo S, Turato G, Badin C, Bazzan E, Beghé B, Zuin R, et al: Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thora x 2004; 59: 308-312.
40. Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Parè PD: Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993; 74:2771-2781.
41. Carnevali S, Luppi F, D'Arca D, Caporali A, Ruggieri MP, Vettori MV, et al: Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke. Am J Respir Crit Care Med 2006; 174:393-399.
42. Ballarin A, Bazzan E, Hernandez Zenteno R, Turato G, Baraldo S, Zanovello D, et al: Mast cell infiltration discriminates between histo-pathological phenotypes of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012, E-pub ahead of print, PMID: 22679009.
43. Wright JL, Hobson J, Wiggs BR, Pare PD, Hogg JC: Effect of cigarette smoking on structure of the small airways. Lung 1987; 165:91-100.
44. Finkelstein R, Fraser RS, Ghezzo H, Cosio MG: Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med 1995; 152:1666-1672.
45. Deveci F, Murat A, Turgut T, Altuntas E, Muz MH: Airway wall thickness in patients with COPD and healthy current smokers and healthy non-smokers: assessment with high resolution computed tomographic scanning. Respiration 2004; 71: 602-610.
46. Saetta M, Ghezzo H, Kim WD, King M, Angus GE, Wang NS, et al: Loss of alveolar attachments in smokers: an early morphomet-ric correlate of lung function impairment. Am Rev Respir Dis 1985; 132: 894-900.
47. Turato G, Zuin R, Miniati M, Baraldo S, Rea F, Beghe B, et al: Airway inflammation in severe chronic obstructive pulmonary disease: relationship with lung function and radio-logic emphysema. Am J Respir Crit Care Med 2002; 166:105-110.
48. Retamales I, Elliott WM, Meshi B, Coxson HO, Pare PD, Sciurba FC, et al: Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med 2001; 164:469-473.
49. Nagai A, West WW, Paul JL, Thurlbeck WM: The National Institutes of Health Intermittent Positive Pressure Breathing trial: pathology studies. I. Interrelationship between morphologic lesions. Am Rev Respir Dis 1985; 132: 937-945.
50. Polverino F, Baraldo S, Bazzan E, Agostini S, Turato G, Lunardi F, et al: A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family. Am J Respir Crit Care Med 2010; 182: 1011-1019.
51. Baraldo S, Lokaroliani K, Turato G, Zuin R, Saetta M: The role of lymphocytes in the pathogenesis of asthma and COPD. Curr Med Chem 2007; 14: 2250-2256.
52. Van Der Strate BWA, Postma DS, Brandsma CA, Melgert BN, Luinge MA, Geerlings M, et al: Cigarette smoke-induced emphysema: a role for the B cell? Am J Respir Crit Care Med 2006; 173: 751-758.