Amiloride-sensitive and amiloride-insensitive responses to NaCl + acid mixtures in Hamster Chorda Tympani nerve

Chemical Senses

Volumn 37, Issue 7, 2012, Pages 603-612

  Formaker, Bradley K ^a   Hettinger, Thomas P ^a   Savoy, Lawrence D ^a   Frank, Marion E ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Acetic acid; Amiloride sensitivity; Binary mixtures; Chorda tympani; Citric acid; NaCl

Indexed keywords

ACETIC ACID; AMILORIDE; CITRIC ACID; POTASSIUM CHLORIDE; SODIUM CHANNEL; SODIUM CHLORIDE; SUCROSE;

ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC TRANSMISSION; CHORDA TYMPANI; CONTROLLED STUDY; EVOKED RESPONSE; HAMSTER; MALE; NERVE FIBER; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CONDUCTION; TASTE DISCRIMINATION;

ACETIC ACID; AMILORIDE; ANIMALS; CHORDA TYMPANI NERVE; CITRIC ACID; CRICETINAE; ELECTROLYTES; HYDROGEN-ION CONCENTRATION; SODIUM CHANNELS; SODIUM CHLORIDE; TASTE;

EID: 84864834038     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjs042     Document Type: Article

References (46)

1. Awayda MS, Boudreaux MJ, Reger RL, Hamm LL. 2000. Regulation of the epithelial Na+ channel by extracellular acidification. Am J Physiol Cell Physiol. 279:C1896-C1905.
2. Bartoshuk LM. 1975. Taste mixtures: is mixture suppression related to compression? Physiol Behav. 14:643-649.
3. Beatty RM, Cragg LH. 1935. The sourness of acids. J Am Chem Soc. 57:2347-2351.
4. Breza JM, Curtis KS, Contreras RJ. 2006. Temperature modulates taste responsiveness and stimulates gustatory neurons in the rat geniculate ganglion. J Neurophysiol. 95:674-685.
5. Breza JM, Nikonov AA, Contreras RJ. 2010. Response latency to lingual taste stimulation distinguishes neuron types within the geniculate ganglion. J Neurophysiol. 103:1771-1784.
6. Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJP, Zuker CS. 2010. The cells and peripheral representation of sodium taste in mice. Nature. 464:297-301.
7. Chang RB, Waters H, Liman ER. 2010. A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci U S A. 107:22320-22325.
8. Chaudhari N, Roper SD. 2010. The cell biology of taste. J Cell Biol. 190:285-296.
9. Chen J-Y, Di Lorenzo PM. 2008. Responses to binary taste mixtures in the nucleus of the solitary tract: neural coding with firing rate. J Neurophysiol. 99:2144-2157.
10. Dando R, Roper SD. 2009. Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels. J Physiol. 587:5899-5906.
11. Dvoryanchikov G, Huang YA, Barro-Soria R, Chaudhari N, Roper SD. 2011. GABA, its receptors, and GABAergic inhibition in mouse taste buds. J Neurosci. 31:5782-5791.
12. Formaker BK, Frank ME. 1996. Responses of the hamster chorda tympani nerve to binary component taste stimuli: evidence for peripheral gustatory mixture interactions. Brain Res. 727:79-90.
13. Formaker BK, Hill DL. 1988. An analysis of residual NaCl taste response after amiloride. Am J Physiol. 255:R1002-R1007.
14. Formaker BK, Lin H, Hettinger TP, Frank ME. 2009. Responses of the hamster chorda tympani nerve to sucrose + acid and sucrose + citrate taste mixtures. Chem Senses. 34:607-616.
15. Formaker BK, MacKinnon BI, Hettinger TP, Frank ME. 1997. Opponent effects of quinine and sucrose on single-fiber taste responses of the chorda tympani nerve. Brain Res. 772:239-242.
16. Frank M. 1973. An analysis of hamster afferent taste nerve response functions. J Gen Physiol. 61:588-618.
17. Frank ME. 1989. Processing of mixtures of stimuli with different tastes by primary mammalian taste neurons. In: Laing DG, Cain WS, McBride RL, Ache BW, editors. Perception of complex smells and tastes. Australia: Academic Press. p. 127-147.
18. Frank ME, Bieber SL, Smith DV. 1988. The organization of taste sensibilities in hamster chorda tympani nerve fibers. J Gen Physiol. 91:861-896.
19. Frank ME, Formaker BK, Hettinger TP. 2003. Taste responses to mixtures: analytic processing of quality. Behav Neurosci. 117:228-235.
20. Frank ME, Formaker BK, Hettinger TP. 2005. Peripheral gustatory processing of sweet stimuli by golden hamsters. Brain Res Bull. 66:70-84.
21. Frank ME, Goyert HF, Hettinger TP. 2010a. Time and intensity factors in identification of components of odor mixtures. Chem Senses. 35:777-787.
22. Frank ME, Goyert HF, Hettinger TP. 2010b. Coding mixture components in sucrose-NaCl mixtures. AChemS Abstract 294. Chem Senses. 31: A88.
23. Frank ME, Lundy RF Jr, Contreras RJ. 2008. Cracking taste codes by tapping into sensory neuron impulse traffic. Prog Neurobiol. 86:245-263.
24. Frank ME, Nowlis GH. 1989. Learned aversions and taste qualities in hamsters. Chem Senses. 14:379-394.
25. Gilbertson TA, Avenet P, Kinnamon SC, Roper SD. 1992. Proton currents through amiloride-sensitive Na channels in hamster taste cells. Role in acid transduction. J Gen Physiol. 100:803-824.
26. Herness S, Zhao FL. 2009. The neuropeptides CCK and NPY and the changing view of cell-to-cell communication in the taste bud. Physiol Behav. 97:581-591.
27. Hettinger TP, Frank ME. 1990. Specificity of amiloride inhibition of hamster taste responses. Brain Res. 513:24-34.
28. Hill DL, Formaker BK, White KS. 1990. Perceptual characteristics of the amiloride-suppressed sodium chloride taste response in the rat. Behav Neurosci. 104:734-741.
29. Hyman AM, Frank ME. 1980a. Sensitivities of single nerve fibers in the hamster chorda tympani to mixtures of taste stimuli. J Gen Physiol. 76:143-173.
30. Hyman AM, Frank ME. 1980b. Effects of binary taste stimuli on the neural activity of the hamster chorda tympani. J Gen Physiol. 76:125-142.
31. Laing DG, Link C, Jinks AL, Hutchinson I. 2002. The limited capacity of humans to identify the components of taste mixtures and taste-odour mixtures. Perception. 31:617-635.
32. Livermore A, Laing DG. 1996. Influence of training and experience on the perception of multicomponent odor mixtures. J Exp Psychol Hum Percept Perform. 22:267-277.
33. Lyall V, Alam RI, Phan DQ, Ereso GL, Phan TH, Malik SA, Montrose MH, Chu S, Heck GL, Feldman GM, et al. 2001. Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. Am J Physiol Cell Physiol. 281:C1005-C1013.
34. Lyall V, Alam RI, Phan THT, Russell OF, Malik SA, Heck GL, DeSimone JA. 2002. Modulation of rat chorda tympani NaCl responses and intracellular Na+ activity in polarized taste receptor cells by pH. J Gen Physiol. 120:793-815.
35. Ninomiya Y, Funakoshi M. 1988. Amiloride inhibition of responses of rat single chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res. 451:319-325.
36. Ninomiya Y, Funakoshi M. 1989. Behavioral discrimination between glutamate and the four basic taste substances in mice. Comp Biochem Physiol A Comp Physiol. 92:365-370.
37. Ninomiya Y, Mizukoshi T, Nishikawa T, Funakoshi M. 1987. Ion specificity of rat chorda tympani fibers to chemical and electrical tongue stimulations. Brain Res. 404:350-354.
38. Ogawa H. 1969. Effects of pH on taste responses in the chorda tympani nerve of rats. Jpn J Physiol. 19:670-681.
39. Palmer LG, Frindt G. 1987. Effects of cell Ca and pH on Na channels from rat cortical collecting tubule. Am J Physiol. 253:F333-F339.
40. Rehnberg BG, MacKinnon BI, Hettinger TP, Frank ME. 1993. Anion modulation of taste responses in sodium-sensitive neurons of the hamster chorda tympani nerve. J Gen Physiol. 101:453-465.
41. Spector AC, Guagliardo NA, St. John SJ. 1996. Amiloride disrupts NaCl versus KCl discrimination performance: implications for salt taste coding in rats. J Neurosci. 16:8115-8122.
42. Stewart RE, Lyall V, Feldman GM, Heck GL, DeSimone JA. 1998. Acidinduced responses in hamster chorda tympani and intracellular pH tracking by taste receptor cells. Am J Physiol. 44:C227-C238.
43. Wang M-F, Marks LE, Frank ME. 2009. Taste coding after selective inhibition by chlorhexidine. Chem Senses. 34:653-666.
44. Yarmolinsky DA, Zuker CS, Ryba NJP. 2009. Common sense about taste: from mammals to insects. Cell. 139:234-244.
45. Ye Q, Heck GL, DeSimone JA. 1994. Effects of voltage perturbation of the lingual receptive field on chorda tympani responses to Na+ and K+ salts in the rat: implications for gustatory transduction. J Gen Physiol. 104:885-907.
46. Yoshida R, Horio N, Murata Y, Yasumatsu K, Shigemura N, Ninomiya Y. 2009. NaCl responsive taste cells in the mouse fungiform taste buds. Neuroscience. 159:795-803.