Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~400-fold natural background radiation

Environmental Health Perspectives

Volumn 120, Issue 8, 2012, Pages 1130-1136

  Olipitz, Werner ^a   Wiktor Brown, Dominika ^a   Shuga, Joe ^a   Pang, Bo ^a   McFaline, Jose ^a   Lonkar, Pallavi ^a   Thomas, Aline ^a   Mutamba, James T ^a   Greenberger, Joel S ^b   Samson, Leona D ^a   Dedon, Peter C ^a   Yanch, Jacquelyn C ^a   Engelward, Bevin P ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

DNA damage; Gene expression; In vivo; Ionizing radiation; Low dose rate; Micronucleus assay; Mouse

Indexed keywords

8 HYDROXYGUANINE; ATM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HYPOXANTHINE; IODINE 125; PROTEIN MDM2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DOUBLE STRANDED DNA BREAK; ERYTHROCYTE; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOTOXICITY; HOMOLOGOUS RECOMBINATION; IONIZING RADIATION; IRRADIATION; LIQUID CHROMATOGRAPHY; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANIMALS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION PROFILING; MICE; MICE, INBRED C57BL;

ANIMALIA; MUS;

EID: 84864766031     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104294     Document Type: Article

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