Epigenetic gene silencing is a novel mechanism involved in delayed manifestation of radiation-induced genomic instability in mammalian cells

Radiation Research

Volumn 175, Issue 4, 2011, Pages 416-423

  Suzuki, Keiji ^a   Yamaji, Hiroko ^a   Kobashigawa, Shinko ^a   Kawauchi, Rie ^a   Shima, Kazutaka ^a   Kodama, Seiji ^b   Watanabe, Masami ^c  

^a NAGASAKI UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; BETA GALACTOSIDASE;

ANIMAL CELL; ARTICLE; CELL LINE; CHO CELL; EPIGENETICS; GENE DELETION; GENE MUTATION; GENOMIC INSTABILITY; MAMMAL CELL; MUTAGENESIS; MUTANT; MUTATION RATE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, RADIATION; EPIGENESIS, GENETIC; GENE SILENCING; GENOMIC INSTABILITY; MUTATION; RADIATION DOSAGE;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 79953326333     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2391.1     Document Type: Article

References (31)

1. W. F. Morgan, J. P. Day, M. I. Kaplan, E. M. McGhee and C. L. Limoli, Genomic instability induced by ionizing radiation. Radiat. Res. 146, 247-258 (1996). (Pubitemid 26320088)
2. J. B. Little, Genomic instability and bystander effects: a historical perspective. Oncogene 22, 6978-6987 (2003). (Pubitemid 37386665)
3. S. A. Lorimore, P. J. Coates and E. G. Wright, Radiationinduced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 22, 7058-7069 (2003). (Pubitemid 37386675)
4. K. Suzuki, M. Ojima, S. Kodama and M. Watanabe, Radiationinduced DNA damage and delayed induced genomic instability. Oncogene 22, 6988-6993 (2003). (Pubitemid 37386666)
5. M. A. Kadhim, D. A. MacDonald, D. T. Goodhead, S. A. Lorimore, S. J. Marsden and E. G. Wright, Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature 355, 738-740 (1992).
6. K. Suzuki, Multistep nature of X-ray-induced neoplastic transformation in mammalian cells: genetic alteration and instability. J. Radiat. Res. 38, 55-63 (1997). (Pubitemid 127462167)
7. L. Huang, A. R. Snyder and W. F. Morgan, Radiation-induced genomic instability and its implications for radiation carcinogenesis. Oncogene 22, 5848-5854 (2003). (Pubitemid 37176705)
8. O. Niwa, Induced genomic instability in irradiated germ cells and in the offspring; reconciling discrepancies among the human and animal studies. Oncogene 22, 7078-7086 (2003). (Pubitemid 37386677)
9. W. F. Morgan and M. B. Sowa, Non-targeted effects of ionizing radiation: implications for risk assessment and the radiation dose response profile. Health Phys. 97, 426-432 (2009).
10. P. Jacob, R. Meckbach, J. C. Kaiser and M. Sokolnikov, Possible expressions of radiation-induced genomic instability, bystander effects or low-dose hypersensitivity in cancer epidemiology. Mutat. Res. 687, 34-39 (2010).
11. M. A. Kadhim, R. Lee, S. R. Moore, D. A. Macdonald, K. L. Chapman, G. Patel and K. M. Prise, Genomic instability after targeted irradiation of human lymphocytes: evidence for interindividual differences under bystander conditions. Mutat. Res. 688, 91-94 (2010).
12. S. I. Salomaa, E. G. Wright, G. Hildebrandt, M. A. Kadhim, M. P. Little, K. M. Prise and O. V. Belyakov, Non-DNA targeted effects. Mutat. Res. 687, 1-2 (2010).
13. E. G. Wright, Manifestations and mechanisms of non-targeted effects of ionizing radiation. Mutat. Res. 687, 28-33 (2010).
14. J. B. Little, L. Gorgojo and H. Vetrovs, Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 19, 1425-1429 (1990).
15. W. P. Chang and J. B. Little, Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving Xirradiation: association with delayed reproductive death phenotype. Mutat. Res. 270, 191-199 (1992).
16. J. B. Little, H. Nagasawa, T. Pfenning and H. Vetrovs, Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles. Radiat. Res. 148, 299-307 (1997). (Pubitemid 27435629)
17. K. Harper, S. A. Lorimore and E. G. Wright, Delayed appearance of radiation-induced mutations at the Hprt locus in mirine hemopoietic cells. Exp. Hematol. 25, 263-269 (1997). (Pubitemid 27130305)
18. L. Huang, S. Grim, L. E. Smith, P. M. Kim, J. A. Nickoloff, O. G. Goloubeva and W. F. Morgan, Ionizing radiation induces delayed hyperrecombination in mammalian cells. Mol. Cell. Biol. 24, 5060-5068 (2004). (Pubitemid 38668067)
19. J. A. Downs, Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. DNA Repair 7, 2020-2024 (2008).
20. C. Dinant and M. S. Luijsterburg, The emerging role of HP1 in the DNA damage response. Mol. Cell. Biol. 29, 6335-6340 (2009).
21. T. Misteli and E. Soutoglou, The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat. Rev. Mol. Cell. Biol. 10, 243-254 (2009).
22. T. K. Pandita and C. Richardson, Chromatin remodeling finds its place in the DNA double-strand break response. Nucleic Acids Res. 37, 1363-1377 (2009).
23. S. V. Costes, I. Chiolo, J. M. Pluth, M. H. Barcellos-Hoff and B. Jacob, Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat. Res. 704, 78-87 (2010).
24. M. Falk, E. Lukasova and S. Kozubek, Higher-order chromatin structure in DSB induction, repair and misrepair. Mutat. Res. 704, 88-100 (2010).
25. S. R. Moore, D. Papworth and A. J. Grosovsky, Non-random distribution of instability-associated chromosomal rearrangement breakpoints in human lymphoblastoid cells. Mutat. Res. 600, 113-124 (2006).
26. H. Toyokuni, A. Maruo, K. Suzuki and M. Watanabe, The contribution of radiation-induced large deletion of the genome to chromosomal instability. Radiat. Res. 171, 198-203 (2009).
27. H. Cedar and Y. Bergman, Linking DNA methylation and histone modification: patterns and paradigm. Nat. Rev. Genet. 10, 295-304 (2009).
28. X. Cheng and R. M. Blumenthal, Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry 49, 2999-3008 (2010).
29. P. Chi, C. D. Allis and G. G. Wang, Covalent histone modifications- miswritten, misinterpreted and mis-erased in human cancers. Nat. Rev. Cancer 10, 457-469 (2010).
30. L. Ho and G. R. Crabtree, Chromatin remodelling during development. Nature 463, 474-484 (2010).
31. A. Shilatifard, Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu. Rev. Biochem. 75, 243-269 (2006). (Pubitemid 44118033)