The variable N-terminal region of DDX5 contains structural elements and auto-inhibits its interaction with NS5B of hepatitis C virus

Biochemical Journal

Volumn 446, Issue 1, 2012, Pages 37-46

  Dutta, Sujit ^a,b   Gupta, Garvita ^c   Choi, Yook Wah ^a,d   Kotaka, Masayo ^e   Fielding, Burtram C ^d   Song, Jianxing ^c,f   Tan, Yee Joo ^a,f  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b DEPARTMENT OF ELECTRONICS AND COMPUTER ENGINEERING   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Auto inhibition; DDX5; DEAD box family; Hepatitis C virus; N terminal region; NS5B

Indexed keywords

DDX5 ENZYME; DEAD BOX PROTEIN; NONSTRUCTURAL PROTEIN 5B; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; HEPATITIS C; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DEAD-BOX RNA HELICASES; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84864755881     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120001     Document Type: Article

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