Impaired insulin signaling in an animal model of Niemann-Pick Type C disease

Biochemical and Biophysical Research Communications

Volumn 424, Issue 3, 2012, Pages 482-487

  Ong, Qi Rui ^a   Lim, Mei Li ^a   Chua, Ching Ching ^a   Cheung, Nam Sang ^b   Wong, Boon Seng ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DEAKIN UNIVERSITY   (Australia)

Author keywords

GSK3beta; Insulin signaling; Niemann Pick Type C disease; NPC

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P85; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; INSULIN RELEASE; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; NIEMANN-PICK DISEASE, TYPE C; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA; MUS;

EID: 84864755470     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.139     Document Type: Article

References (30)

1. Vance J.E. Lipid imbalance in the neurological disorder, Niemann-Pick C disease. FEBS Lett. 2006, 580:5518-5524.
2. Vanier M.T. Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature. Neurochem. Res. 1999, 24:481-489.
3. Karten B., Campenot R.B., Vance D.E., Vance J.E. The Niemann-Pick C1 protein in recycling endosomes of presynaptic nerve terminals. J. Lipid Res. 2006, 47:504-514.
4. Carstea E.D., Morris J.A., Coleman K.G., Loftus S.K., Zhang D., et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 1997, 277:228-231.
5. Loftus S.K., Morris J.A., Carstea E.D., Gu J.Z., Cummings C., et al. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science 1997, 277:232-235.
6. Reddy J.V., Ganley I.G., Pfeffer S.R. Clues to neuro-degeneration in Niemann-Pick Type C disease from global gene expression profiling. PLoS One 2006, 1:e19.
7. Burns M., Gaynor K., Olm V., Mercken M., LaFrancois J., et al. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J. Neurosci. 2003, 23:5645-5649.
8. Jin L.W., Shie F.S., Maezawa I., Vincent I., Bird T. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am. J. Pathol. 2004, 164:975-985.
9. Yamazaki T., Chang T.Y., Haass C., Ihara Y. Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. J. Biol. Chem. 2001, 276:4454-4460.
10. Distl R., Treiber-Held S., Albert F., Meske V., Harzer K., et al. Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain. J. Pathol. 2003, 200:104-111.
11. Saito Y., Suzuki K., Nanba E., Yamamoto T., Ohno K., et al. Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity. Ann. Neurol. 2002, 52:351-355.
12. Chua C.C., Lim M.L., Wong B.S. Altered apolipoprotein E glycosylation is associated with Abeta(42) accumulation in an animal model of Niemann-Pick Type C disease. J. Neurochem. 2010, 112:1619-1626.
13. Hallows J.L., Iosif R.E., Biasell R.D., Vincent I. P35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease. J. Neurosci. 2006, 26:2738-2744.
14. Treiber-Held S., Distl R., Meske V., Albert F., Ohm T.G. Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease. J. Pathol. 2003, 200:95-103.
15. Yu W., Ko M., Yanagisawa K., Michikawa M. Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. J. Biol. Chem. 2005, 280:27296-27302.
16. Suzuki R., Lee K., Jing E., Biddinger S.B., McDonald J.G., et al. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab. 2010, 12:567-579.
17. Deng Y., Li B., Liu Y., Iqbal K., Grundke-Iqbal I., et al. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. Am. J. Pathol. 2009, 175:2089-2098.
18. Planel E., Tatebayashi Y., Miyasaka T., Liu L., Wang L., et al. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J. Neurosci. 2007, 27:13635-13648.
19. Liu Y., Liu F., Grundke-Iqbal I., Iqbal K., Gong C.X. Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease. J. Neurochem. 2009, 111:242-249.
20. Chang T.Y., Reid P.C., Sugii S., Ohgami N., Cruz J.C., et al. Niemann-Pick type C disease and intracellular cholesterol trafficking. J. Biol. Chem. 2005, 280:20917-20920.
21. Porter F.D., Scherrer D.E., Lanier M.H., Langmade S.J., Molugu V., et al. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Sci. Transl. Med. 2010, 2:56ra81.
22. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
23. Goh A.X., Li C., Sy M.S., Wong B.S. Altered prion protein glycosylation in the aging mouse brain. J. Neurochem. 2007, 100:841-854.
24. Liu Y., Liu F., Grundke-Iqbal I., Iqbal K., Gong C.X. Deficient brain insulin signaling pathway in Alzheimer's disease and diabetes. J. Pathol. 2011, 225:54-62.
25. Moloney A.M., Griffin R.J., Timmons S., O'Connor R., Ravid R., et al. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signaling. Neurobiol. Aging 2010, 31:224-243.
26. Kitamura T., Kahn C.R., Accili D. Insulin receptor knockout mice. Annu. Rev. Physiol. 2003, 65:313-332.
27. Shineman D.W., Dain A.S., Kim M.L., Lee V.M. Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase. Biochemistry 2009, 48:3787-3794.
28. Bi X., Liu J., Yao Y., Baudry M., Lynch G. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain. Am. J. Pathol. 2005, 167:1081-1092.
29. Stuenaes J.T., Bolling A., Ingvaldsen A., Rommundstad C., Sudar E., et al. Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA. Br. J. Pharmacol. 2010, 160:116-129.
30. White M.F. Insulin signaling in health and disease. Science 2003, 302:1710-1711.