Altered apolipoprotein e glycosylation is associated with Aβ(42) accumulation in an animal model of Niemann-Pick Type C disease

Journal of Neurochemistry

Volumn 112, Issue 6, 2010, Pages 1619-1626

  Chua, Ching Ching ^a   Lim, Mei Li ^a   Wong, Boon Seng ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Amyloid; Apolipoprotein E; Glycosylation; Lectin ELISA; Neurodegeneration; Niemman Pick Type C; NPC1

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; GLYCAN; LECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOREACTIVITY; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGE FACTORS; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOLIPOPROTEINS E; BRAIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GLYCOSYLATION; LECTINS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NIEMANN-PICK DISEASE, TYPE C; PEPTIDE FRAGMENTS; POLYSACCHARIDES; PROTEINS;

ANIMALIA; MUS;

EID: 77349099238     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06586.x     Document Type: Article

References (22)

1. Aleshkov S. B., Li X., Lavrentiadou S. N. Zannis V. I. (1999) Contribution of cysteine 158, the glycosylation site threonine 194, the amino- and carboxy-terminal domains of apolipoprotein E in the binding to amyloid peptide beta (1-40). Biochemistry 38, 8918 8925.
2. Burns M., Gaynor K., Olm V. et al. (2003) Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J. Neurosci. 23, 5645 5649.
3. Goh A. X., Li C., Sy M. S. Wong B. S. (2007) Altered prion protein glycosylation in the aging mouse brain. J. Neurochem. 100, 841 854.
4. Haltiwanger R. S. Lowe J. B. (2004) Role of glycosylation in development. Annu. Rev. Biochem. 73, 491 537.
5. Huang Y., Weisgraber K. H., Mucke L. Mahley R. W. (2004) Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J. Mol. Neurosci. 23, 189 204.
6. Jin L. W., Shie F. S., Maezawa I., Vincent I. Bird T. (2004) Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am. J. Pathol. 164, 975 985.
7. Li H., Repa J. J., Valasek M. A., Beltroy E. P., Turley S. D., German D. C. Dietschy J. M. (2005) Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J. Neuropathol. Exp. Neurol. 64, 323 333.
8. Loftus S. K., Morris J. A., Carstea E. D. et al. (1997) Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science 277, 232 235.
9. Mahley R. W. Rall S. C. Jr. (2000) Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1, 507 537.
10. Mahley R. W., Weisgraber K. H. Huang Y. (2006) Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl Acad. Sci. USA 103, 5644 5651.
11. Pan T., Li R., Wong B. S., Kang S. C., Ironside J. Sy M. S. (2005) Novel antibody-lectin enzyme-linked immunosorbent assay that distinguishes prion proteins in sporadic and variant cases of creutzfeldt-jakob disease. J. Clin. Microbiol. 43, 1118 1126.
12. Poirier J. (2003) Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. Trends Mol. Med. 9, 94 101.
13. Reddy J. V., Ganley I. G. Pfeffer S. R. (2006) Clues to neuro-degeneration in Niemann-Pick Type C disease from global gene expression profiling. PLoS ONE 1, e19.
14. Saito Y., Suzuki K., Nanba E., Yamamoto T., Ohno K. Murayama S. (2002) Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity. Ann. Neurol. 52, 351 355.
15. Sugano M., Yamauchi K., Kawasaki K., Tozuka M., Fujita K., Okumura N. Ota H. (2008) Sialic acid moiety of apolipoprotein E3 at Thr(194) affects its interaction with beta-amyloid(1-42) peptides. Clin. Chim. Acta 388, 123 129.
16. Vance J. E. (2006) Lipid imbalance in the neurological disorder, Niemann-Pick C disease. FEBS Lett. 580, 5518 5524.
17. Vanier M. T. (1999) Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature. Neurochem. Res. 24, 481 489.
18. Wernette-Hammond M. E., Lauer S. J., Corsini A., Walker D., Taylor J. M. Rall S. C. Jr. (1989) Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194. J. Biol. Chem. 264, 9094 9101.
19. Wolozin B. (2004) Cholesterol and the biology of Alzheimer's disease. Neuron 41, 7 10.
20. Yamazaki T., Chang T. Y., Haass C. Ihara Y. (2001) Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. J. Biol. Chem. 276, 4454 4460.
21. Zanni E. E., Kouvatsi A., Hadzopoulou-Cladaras M., Krieger M. Zannis V. I. (1989) Expression of ApoE gene in Chinese hamster cells with a reversible defect in O-glycosylation. Glycosylation is not required for apoE secretion. J. Biol. Chem. 264, 9137 9140.
22. Zannis V. I., vanderSpek J. Silverman D. (1986) Intracellular modifications of human apolipoprotein E. J. Biol. Chem. 261, 13415 13421.