Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells

Biochemical Journal

Volumn 446, Issue 1, 2012, Pages 79-87

  Wang, Shanshan ^a   Wang, Zhao ^a   Lin, Shengchen ^a   Zheng, Weili ^a   Wang, Rui ^a   Jin, Shikai ^a   Chen, Jinan ^a   Jin, Lihua ^a   Li, Yong ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

Cancer chemoprevention; Crystal structure; Luffariellolide; Nuclear receptor; Retinoic acid receptor (RAR)

Indexed keywords

ANTINEOPLASTIC AGENT; ESTROGEN RELATED RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR; LIVER X RECEPTOR ALPHA; LUFFARIELLOLIDE; MESSENGER RNA; NUCLEAR RECEPTOR NR6A1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR BETA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SESTERTERPENE; UNCLASSIFIED DRUG;

AGONIST; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CELL STRAIN COS7; CHEMICAL STRUCTURE; COLON CANCER; CONFORMATION; CRYSTAL STRUCTURE; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; AQUATIC ORGANISMS; BINDING SITES; BIOLOGICAL AGENTS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LEUKEMIA, MONOCYTIC, ACUTE; MOLECULAR SEQUENCE DATA; RECEPTORS, RETINOIC ACID; TERPENES;

EID: 84864750531     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120726     Document Type: Article

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