Retinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism

Cancer Research

Volumn 65, Issue 21, 2005, Pages 9923-9933

  Park, Eun Young ^a   Dillard, Alice ^a   Williams, Elizabeth A ^a   Wilder, Erik T ^a   Pepper, M Reese ^a   Lane, Michelle A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DRUG METABOLITE; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR BLOCKING AGENT; RETINOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL STRAIN HCT116; CELL STRAIN HCT15; CELL STRAIN SW620; CELL STRAIN WIDR; COLON CANCER; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME ASSAY; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CHLORAMPHENICOL O-ACETYLTRANSFERASE; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; HCT116 CELLS; HUMANS; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; TRANSFECTION; TRETINOIN; VITAMIN A;

EID: 27544438129     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1604     Document Type: Article

References (48)

1. Niles RM. Signaling pathways in retinoid chemoprevention and treatment of cancer. Mutat Res 2004;555: 81-96.
2. Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 2003;22:7305-15.
3. Dragnev KH, Petty WJ, Dmitrovsky E. Retinoid targets in cancer therapy and chemoprevention. Cancer Biol Ther 2003;2:S150-6.
4. Zheng Y, Kramer PM, Lubet RA, et al. Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. Carcinogenesis 1999;20:255-60.
5. Zheng Y, Kramer PM, Olson G, et al. Prevention by retinoids of azoxymethane-induced tumors and aberrant crypt foci and their modulation of cell proliferation in the colon of rats. Carcinogenesis 1997;18:2119-25.
6. Wargovich MJ, Jimenez A, McKee K, et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 2000; 21:1149-55.
7. Delage B, Groubet R, Pallet V, et al. Vitamin A prevents high fat diet-induced ACF development and modifies the pattern of expression of peroxisome proliferator and retinoic acid receptor m-RNA Nutr Cancer 2004;48:28-36.
8. Vogel S, Gamble MV, Blaner WS. Biosynthesis, absorption, metabolism and transport of retinoids. In: Nau H and Blaner WS, editors. Retinoids: the biochemical and molecular basis of vitamin A and retinoid action. Berlin: Springer-Verlag 1999. p.31-95.
9. Nicke B, Kaiser A, Wiedenmann B, Riecken EO, Rosewicz S. Retinoic acid receptor a mediates growth inhibition by retinoids in human colon carcinoma HT29 cells. Biochem Biophys Res Commun 1999;21:572-7.
10. Nicke B, Riecken EO, Rosewicz S. Induction of retinoic acid receptor b mediates growth inhibition in retinoid resistant human colon carcinoma cells. Gut 1999;45:51-7.
11. Lee MO, Han SY, Jiang S, Park JH, Kim SJ. Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor β. Biochem Pharmacol 2000;59:485-96.
12. Guo X, Gudas LJ. Metabolism of all-trans-retinol in normal human cell strains and squamous cell carcinoma (SCC) lines from the oral cavity and skin: reduced esterification of retinol in SCC lines. Cancer Res 1998;58: 166-76.
13. Achkar CC, Derguini F, Blumberg B, et al. 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. Proc Natl Acad Sci U S A 1996;93:4879-84.
14. Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ. Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells. Proc Natl Acad Sci U S A 1999; 96:13524-9.
15. Turowski G, Rashid Z, Hong F, Madri JA, Basson MD. Glutamine modulates phenotype and stimulates proliferation in human colon cancer cell lines. Cancer Res 1994;54:5974-80.
16. Ormerod MG. Flow Cytometry a practical approach, 2nd ed. New York Oxford University Press, Inc.; 1992.
17. Sonneveld E, van den Brink CE, van der Leede BM, et al. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through HA receptors in human breast and colon carcinoma cells. Cell Growth Differ 1998;9:629-37.
18. Waliszewski P, Waliszewska MK, Gupta M, Milsom JW, Hurst RE. Expression of retinoid-responsive genes occurs in colorectal carcinoma-derived cells irrespective of the presence of resistance to all-trans retinoic acid. J Surg Oncol Suppl 1997;66:156-67.
19. Lee MO, Kang HJ. Role of coactivators and corepressors in the induction of the RARβ gene in human colon cancer cells. Biol Pharm Bull 2002;25:1298-302.
20. Smith FR, Goodman DS. The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J Clin Invest 1971;50:2426-36.
21. De Leenheer AP, Lambert WE, Claeys I. All-trans retinoic acid: measurement of reference values in human serum by high performance liquid chromatography. J Lipid Res 1982;23:1362-7.
22. Eckhoff C, Nau H. Identification and quantitation of all-trans and 13-cis retinoic acid and 13-cis-4-oxoretinoic acid in human plasma. J Lipid Res 1990;31: 1445-54.
23. Wu S, Dongmei Z, Zhang Z-P, Soprano DR, Soprano KJ. Critical role of both retinoid nuclear receptors and retinoid-X-receptors in mediating growth inhibition of ovarian cancer cells by all-trans-retinoic acid. Oncogene 1998;17:2839-49.
24. Guo X, Knudsen BS, Peehl DM, et al. Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Cancer Res 2002;62:1654-61.
25. Klein ES, Pino ME, Johnson AT, et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem 1996;271:22692-6.
26. Jette C, Peterson PW, Sandoval IT, et al. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. J Biol Chem 2004;279: 34397-405.
27. O'Connell MJ, Chua R, Hoyos B, et al. Retro-retinoids in regulated cell growth and death. J Exp Med 1996;184: 549-55.
28. Hoyos B, Imam A, Korichneva I, et al. Activation of c-Raf kinase by ultraviolet light J Biol Chem 2002;277: 23949-57.
29. Wu S, Zhang ZP, Zhang D, Soprano DR, Soprano KJ. Reduction of both RAR and RXR levels is required to maximally alter sensitivity of CA-OV3 ovarian tumor cells to growth suppression by all-trans-retinoic acid. Exp Cell Res 1997;237:118-26.
30. Maziere S, Cassand P, Narbonne JF, Meflah K. Vitamin A and apoptosis in colonic tumor cells. Int J Vitam Nutr Res 1997;67:237-41.
31. Um SJ, Han HS, Kwon YJ, et al. Novel retinoic acid derivative ABPN has potent inhibitory activity on cell growth and apoptosis in cancer cells. Int J Cancer 2003; 107:1038-46.
32. Pereira MA. Prevention of colon cancer and modulation of aberrant crypt foci, cell proliferation, and apoptosis by retinoids and NSAIDs. Adv Exp Med Biol 1999;470:55-63.
33. Ocker M, Herold C, Ganslmayer M, Hahn EG, Schuppan D. The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int J Cancer 2003;107:453-9.
34. Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E. Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism. Proc Natl Acad Sci U S A 1997;94:12070-4.
35. Boyle J, Langenfeld J, Lonardo F, et al. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J Natl Cancer Inst 1999; 91:373-9.
36. Teixeira C, Pratt MAC. CDK2 is a target for retinoic acid-mediated growth inhibition in MCF-7 human breast cancer cells. Mol Endocrinol 1997;11:1191-202.
37. Zhou Q, Stetler-Stevenson M, Steeg PS. Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro. Oncogene 1997;15:107-15.
38. Zhu W, Jones CS, Kiss A, et al. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells. Exp Cell Res 1997;234:293-9.
39. Imam A, Hoyos B, Swenson C, et al. Retinoids as ligands and coactivators of protein kinase Cα. FASEB J Online 2000;10.1096/fj.00-0329fje.
40. Korichneva I, Hammerling U. F-actin as a target for retro-retinoids: a potential role in anhydroretinol-triggered cell death. J Cell Sci 1999;112:2521-8.
41. Korichneva I, Waka J, Hammerling U. Regulation of the cardiac mitochondrial membrane potential by retinoids. J Pharmacol Exp Ther 2003;305:426-33.
42. Oridate N, Suzuki S, Higuchi M, et al. Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. J Natl Cancer Inst 1997;89:1191-8.
43. Wang H, Maurer BJ, Reynolds CP, Cabot MC. N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. Cancer Res 2001;61:5102-5.
44. Chen YR, Zhou G, Tan TH. c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide. Mol Pharmacol 1999;56:1271-9.
45. Fisher GJ, Talwar HS, Lin J, et al. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 1998;101:1432-40.
46. Sah JF, Eckert RL, Chandraratna RA, Rorke EA. Retinoids suppress epidermal growth factor-associated cell proliferation by inhibiting epidermal growth factor receptor-dependent ERK1/2 activation. J Biol Chem 2002;277:9728-35.
47. Lopez-Carballo G, Moreno L, Masiá S, Pérez P, Barettino D. Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J Biol Chem 2002;277:25297-304.
48. Lonardo F, Dragnev KH, Freemantle SJ, et al. Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. Clin Cancer Res 2002; 8:54-60.