Ucp2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Simon Areces, Julia ^a   Dietrich, Marcelo O ^b,c   Hermes, Gretchen ^b   Garcia Segura, Luis Miguel ^a   Arevalo, Maria Angeles ^a   Horvath, Tamas L ^b,c  

^a INSTITUTO CAJAL   (Spain)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL COUNT; CELL SIZE; CESAREAN SECTION; CONTROLLED STUDY; DENDRITE; EMBRYO; GENE EXPRESSION; HIPPOCAMPUS; MAZE TEST; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; OPEN FIELD TEST; PROTEIN EXPRESSION; SPATIAL MEMORY; SYNAPTOGENESIS; VAGINAL DELIVERY;

ANIMALS; BEHAVIOR, ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DENDRITES; HIPPOCAMPUS; ION CHANNELS; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MODELS, GENETIC; NEURONS; SYNAPSES;

MUS;

EID: 84864709300     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042911     Document Type: Article

References (20)

1. Herrera E, Amusquivar E, (2000) Lipid metabolism in the fetus and the newborn. Diabetes Metab Res Rev 16: 202-210.
2. Andrews Z, Liu Z, Walllingford N, Erion D, Borok E, et al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454: 846-851.
3. Negre-Salvayre A, Hirtz C, Carrera G, Cazenave R, Troly M, et al. (1997) A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J 11: 809-815.
4. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, et al. (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26: 435-9.
5. Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, et al. (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol 64: 363-367.
6. Dietrich MO, Andrews ZB, Horvath TL, (2008) Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci 28: 10766-10771.
7. Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, et al. (2003) Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for pre-conditioning. Endocrinology 144: 5014-21.
8. Sullivan PG, Dube C, Dorenbos K, Steward O, Baram TZ, (2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol 53: 711-717.
9. Horvath B, Spies C, Horvath G, Kox WJ, Miyamoto S, et al. (2002) Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol 64: 369-74.
10. Simon-Areces J, Membrive G, Garcia-Fernandez C, Garcia-Segura LM, Arevalo MA, (2010) Neurogenin 3 cellular and subcellular localization in the developing and adult hippocampus. J Comp Neurol 518: 1814-1824.
11. Dotti CG, Sullivan CA, Banker GA, (1988) The establishment of polarity by hippocampal neurons in culture. J Neurosci 8: 1454-1468.
12. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, et al. (2006) Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced [beta] cell dysfunction in isolated pancreatic islets. Cell Metabolism 3: 417-427.
13. Andrews Z, Horvath B, Barnstable CJ, Elsworth J, Yang L, et al. (2005) UCP2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. Journal of Neuroscience 25: 184-191.
14. Tsai SY, Hayashi T, Harvey BK, Wang Y, Wu WW, et al. (2009) Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway. Proc Natl Acad Sci U S A 106: 22468-22473.
15. Kemp BE, Mitchelhill KI, Stapleton D, Michell BJ, Chen ZP, et al. (1999) Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci 24: 22-25.
16. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, et al. (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415: 96-99.
17. Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, et al. (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37: 755-767.
18. Conti B, Sugama S, Lucero J, Winsky-Sommerer R, Wirz SA, et al. (2005) UCP2 protects catecholaminergic neurons from acute MPTP toxicity. J Neurochemistry 93: 493-501.
19. Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, et al. (2009) Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci 29: 14057-65.
20. Deierborg T, Wieloch T, Diano S, Warden CH, Horvath TL, et al. (2008) Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J Cereb Blood Flow Metab 28: 1186-1195.