Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens

International Journal of Obesity

Volumn 36, Issue 8, 2012, Pages 1054-1061

  Jia, X ^a,b   Nie, Q ^a,b   Lamont, S J ^c   Zhang, X ^a,b  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b Guangdong Provincial Key Lab of Agro Animal Genomics and Molecular Breeding   (China)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

association analysis; avian; chicken; fatness; FTO

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY GROWTH; BODY WEIGHT; BRAIN; BREAST; CEREBELLUM; CHICKEN; CONTROLLED STUDY; DIET RESTRICTION; DUCK; EMBRYO; FEMALE; FIBROBLAST; FTO GENE; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC TRAIT; GLUCOSE INTAKE; GLUCOSE METABOLISM; HYPOPHYSIS; LEG MUSCLE; LIVER; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT;

ANIMALS; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY WEIGHT; CHICKENS; DUCKS; FEMALE; GEESE; GLUCOSE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANSER; AVES; GALLUS GALLUS; MAMMALIA;

EID: 84864707357     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2011.221     Document Type: Article

References (48)

1. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894. (Pubitemid 46764279)
2. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115.
3. Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726. (Pubitemid 46848595)
4. Cha SW, Choi SM, Kim KS, Park BL, Kim JR, Kim JY et al. Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. Obesity (Silver Spring) 2008; 16: 2187-2189.
5. Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R et al. Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet 2008; 53: 546-553. (Pubitemid 351749344)
6. Tan JT, Dorajoo R, Seielstad M, Sim XL, Ong RT, Chia KS et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. Diabetes 2008; 57: 2851-2857.
7. Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes 2010; 59: 3085-3089.
8. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, Van Gaal L et al. Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 2008; 93: 481-484. (Pubitemid 351381467)
9. Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, Loos RJ et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 2010; 19: 545-552.
10. Cecil JE,Tavendale R,Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO genevariant and increased energy intake in children. N Engl J Med 2008; 359: 2558-2566.
11. Pecioska S, Zillikens MC, Henneman P, Snijders PJ, Oostra BA, van Duijn CM et al. Association between type2 diabetes loci and measures offatness. PLoS One2010; 5: e8541.
12. Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr 2009; 90: 951-959.
13. Tönjes A, Zeggini E, Kovacs P, Böttcher Y, Schleinitz D, Dietrich K et al. Association of FTO variants with BMI and fat mass in the self-contained population of sorbs in Germany. Eur J Hum Genet 2010; 18: 104-110.
14. Kaakinen M, Läärä E, Pouta A, Hartikainen AL, Laitinen J, Tammelin TH et al. Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol 2010; 172: 653-665.
15. Attaoua R, Ait El Mkadem S, Lautier C, Kaouache S, Renard E, Brun JF et al. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. Diabetes Metab 2009; 35: 476-483.
16. Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjöström L, Bouchard C et al. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes (Lond) 2011; 35: 676-683.
17. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfält E, Orho-Melander M. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 2009; 90: 1418-1425.
18. Grant SF, Li M, Bradfield JP, Kim CE, Annaiah K, Santa E et al. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One 2008; 3: e1746.
19. Hassanein MT, Lyon HN, Nguyen TT, Akylbekova EL, Waters K, Lettre G et al. Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet 2010; 19: 2907-2916.
20. Ewens KG, Jones MR, Ankener W, Stewart DR, Urbanek M, Dunaif A et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS One 2011; 6: e16390.
21. Adeyemo A, Chen G, Zhou J, Shriner D, Doumatey A, Huang H et al. FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes 2010; 59: 1549-1554.
22. Mei H, Chen W, Srinivasan SR, Jiang F, Schork N, Murray S et al. FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI. Hum Genet 2010; 128: 589-596.
23. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Bruning JC et al. Inactivation of the Fto gene protects from obesity. Nature 2009; 458: 894-898.
24. Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 2010; 5: e14005.
25. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2010; 5: e1000599.
26. Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 2010; 42: 1086-1092.
27. Fontanesi L, Scotti E, Buttazzoni L, Dall'Olio S, Bagnato A, Lo Fiego DP et al. Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs. Mol Biol Rep 2010; 37: 461-466.
28. Fan B, Du ZQ, Rothschild MF. The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig. Anim Biotechnol 2009; 20: 58-70.
29. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethy-lase. Science 2007; 318: 1469-1472. (Pubitemid 350208961)
30. Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP etal. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 2010; 5: e8771.
31. Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J et al. FTO is increased in muscle during type 2 diabetes and its over-expression in myotubes alters insulin signalling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes 2011; 60: 258-268.
32. Poritsanos NJ, Lew PS, MizunoTM. Relationship between blood glucose levels and hepatic Fto mRNA expression in mice. Biochem Biophys Res Commun 2010; 400: 713-717.
33. Grunnet LG, Nilsson E, Ling C, Hansen T, Pedersen O, Groop L et al. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes 2009; 58: 2402-2408.
34. Lei M, Nie Q, Peng X, Zhang D, Zhang X. Single nucleotide polymorphisms of the chicken insulin-like factor binding protein 2 gene associated with chicken growth and carcass traits. Poult Sci 2005; 84: 1191-1198. (Pubitemid 44509814)
35. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265. (Pubitemid 40202029)
36. Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 2010; 464: 1205-1209.
37. Fredriksson R, Hägglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons offeeding-related nuclei of the brain. Endocrinology 2008; 149: 2062-2071. (Pubitemid 351574484)
38. Huang J, Liu G, Liu Y, Yao Y, Wu K, Fang M. Splice variant identification and expression analysis of the fat mass and obesity-associated (FTO) gene in intact and castrated male pigs. DNA Cell Biol 2010; 29: 729-733.
39. Madsen MB, Birck MM, Fredholm M, Cirera S. Expression studies of the obesity candidate gene FTO in pig. Anim Biotechnol 2010; 21: 51-63.
40. Arnold AS, Egger A, Handschin C. PGC-1alpha and myokines in the aging muscle-a mini-review. Gerontology 2011; 57: 37-43.
41. Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW et al. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. CellMetab 2010; 12: 633-642.
42. Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A et al. PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha. Mitochondrion 2010; 10: 516-527.
43. Becerril S, Gomez-Ambrosi J, Rodriguez A, Catalan V, Fruhbeck G. Absence of inos increases energy expenditure in ob/ob mice through an upregulation in PGC1-alpha expression. Int J Obesity 2008; 32: S80.
44. Schuler M, Ali F, Chambon C, Duteil D, Bornert JM, Tardivel A et al. PGC1 alpha expression is controlled in skeletal muscles by PPAR beta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. CellMetab 2006; 4:407-414. (Pubitemid 44645068)
45. Espinoza DO, Patti ME. PGC1 expression alters lipid metabolism and partitioning in skeletal muscle cells: potential links to insulin resistance susceptibility. Diabetes 2005; 54: A360.
46. Barres R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab 2009; 10: 189-198.
47. Buettner C, Pocai A, Muse ED, Etgen AM, Myers Jr MG, Rossetti L. Critical role of STAT3 in leptin's metabolic actions. Cell Metab 2006; 4: 49-60. (Pubitemid 43942253)
48. Chiu HK, Qian K, Ogimoto K, Morton GJ, Wisse BE, Agrawal N et al. Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis. Endocrinology 2010; 151: 993-1001.