Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices

Neuroscience Letters

Volumn 274, Issue 2, 1999, Pages 111-114

  Scharfman, Helen E ^a,b   Hodgkins, Paul S ^c   Lee, Song Chu ^c   Schwarcz, Robert ^c  

^a HELEN HAYES HOSPITAL   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Epilepsy; Glutamate; Glycine; N methyl D aspartate; Neuroprotection; Tryptophan

Indexed keywords

KYNURENIC ACID; KYNURENINE; MAGNESIUM;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; IN VITRO STUDY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BUFFERS; ENTORHINAL CORTEX; EPILEPSY; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HIPPOCAMPUS; KYNURENIC ACID; MAGNESIUM; MALE; NEUROTRANSMITTER AGENTS; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; TRYPTOPHAN;

EID: 0032881394     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00690-4     Document Type: Article

References (21)

1. Anderson W.W., Lewis D.V., Swartzwelder H.S., Wilson W.A. Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res. 398:1986;215-219.
2. Baran H., Gramer M., Hönack D., Löscher W. Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats. Eur. J. Pharmacol. 286:1995;167-175.
3. Du F., Schmidt W., Okuno E., Kido R., Köhler C., Schwarcz R. Localization of kynurenine aminotransferase immunoreactivity in the rat hippocampus. J. Comp. Neurol. 321:1992;477-487.
4. Eastman C.L., Guilarte T.R. The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine. Neurochem. Res. 15:1990;1101-1107.
5. 3H] kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway. J. Neurochem. 65:1995;2621-2632.
6. Guidetti P., Okuno E., Schwarcz R. Characterization of rat brain kynurenine aminotransferase I and II. J. Neurosci. Res. 50:1997;457-465.
7. Herron C.E., Malenka R.C. Activity-dependent enhancement of synaptic transmission in hippocampal slices treated with the phosphatase inhibitor calyculin A. J. Neurosci. 10:1994;6013-6020.
8. Moroni F., Russi P., Gallo-Mezo M.A., Moneti G., Pellicciari R. Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine. J. Neurochem. 57:1991;1630-1635.
9. Moroni F., Russi P., Lombardi G., Beni M., Carlà V. Presence of kynurenic acid in the mammalian brain. J. Neurochem. 51:1988;177-180.
10. Okuda S., Nishiyama N., Saito H., Katsuki H. Hydrogen-peroxide mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine. Proc. Natl. Acad. Sci. USA. 93:1996;12553-12558.
11. Okuda S., Nishiyama N., Saito H., Katsuki H. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J. Neurochem. 70:1998;2999-3007.
12. Okuno E., Du F., Ishikawa T., Tsujimoto M., Nakamura M., Schwarcz R., Kido R. Purification and characterization of kynurenine-pyruvate aminotransferase from rat kidney and brain. Brain Res. 534:1990;37-44.
13. Parsons C.G., Danysz W., Quack G., Hartmann S., Lorenz B., Wollenburg C., Baran L., Przegalinski E., Kostowski W., Krzascik P., Chizh B., Headley P.M. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. J. Pharmacol. Exp. Ther. 283:1997;1264-1275.
14. Saito K., Markey S.P., Heyes M.P. Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse. Neuroscience. 51:1992;25-39.
15. Scharfman H.E., Ofer A.A. Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices. Neurosci. Lett. 224:1997;115-118.
16. Stone T.W. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 45:1993;309-379.
17. Turski W.A., Gramsbergen J.B., Traitler H., Schwarcz R. Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine. J. Neurochem. 52:1989;1629-1636.
18. Turski W.A., Nakamura M., Todd W.P., Carpenter B.K., Whetsell W.O. Jr., Schwarcz R. Identification and quantification of kynurenic acid in human brain tissue. Brain Res. 454:1988;164-169.
19. Walther H., Lambert J.D.C., Jones R.S.G., Heinemann U., Hamon B. Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium. Neurosci. Lett. 69:1986;156-161.
20. Wu H.-Q., Schwarcz R. Seizure activity causes elevation of endogenous extracellular kynurenic acid in the rat brain. Brain Res. Bull. 39:1996;155-162.
21. Wu H.-Q., Baran H., Ungerstedt U., Schwarcz R. Kynurenic acid in the quinolinate-lesioned rat hippocampus: studies in vitro and in vivo. Eur. J. Neurosci. 4:1992;1264-1270.