Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human β2-adrenoceptors overexpressed in mouse heart

Molecular Pharmacology

Volumn 65, Issue 5, 2004, Pages 1313-1322

  Heubach, Jürgen F ^a   Ravens, Ursula ^a   Kaumann, Alberto J ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; NORADRENALIN; PERTUSSIS TOXIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; EXPERIMENTAL MOUSE; FEMALE; HEART; HEART CONTRACTION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILE FORCE; HEART RIGHT VENTRICLE; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMULATION; TRANSGENIC MOUSE; ANIMAL; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HEART ATRIUM; HEART MUSCLE; HEART VENTRICLE; HUMAN; METABOLISM;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; EPINEPHRINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEART; HEART ATRIA; HEART VENTRICLES; HUMANS; MICE; MICE, TRANSGENIC; MYOCARDIUM; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 2142815229     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.5.1313     Document Type: Article

References (35)

1. Blinks JR (1965) Convenient apparatus for recording contractions of isolated muscle. J Appl Physiol 20:755-757.
2. 2-adrenoceptor. Nature (Lond) 374:272-276.
3. 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol 35:295-303.
4. i-dependent coupling to phosphatidylinositol 3′-kinase. Circ Res 87:1172-1179.
5. 2-adrenergic receptors on cardiac myocyte apoptosis: role of a pertussis toxin-sensitive G protein. Circulation 100:2210-2212.
6. 2-adrenergc receptor to different G proteins by protein kinase A. Nature (Lond) 390:88-91.
7. Daul A, Hermes U, Schafers RF, Wenzel R, von Birgelen C, and Brodde OE (1995) The beta-adrenoceptor subtype(s) mediating adrenaline- and dobutamine-induced blood pressure and heart rate changes in healthy volunteers. Int J Clin Pharmacol Ther 33:140-148.
8. 2-adrenoceptors in single myocytes from human ventricle. Circulation 88:854-863.
9. Eason MG, Jacinto MT, and Ligget SB (1994) Contribution of ligand structure to activation of α2-adrenergic receptor subtype coupling to Gs. Mol Pharmacol 45: 696-702.
10. 2-adrenergic receptors to two G-proteins with opposing effects. J Biol Chem 267:15795-15801.
11. 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline. Naunyn Schmiedeberg's Arch Pharmacol 331:60-70.
12. 2-adrenoceptor overexpressing mice. Naunyn Schmiedeberg's Arch Pharmacol 364:131-139.
13. 2- adrenoceptor on ligand affinity in transgenic mice. Mol Pharmacol 52:187-194.
14. 2-adrenoceptors in human atrial myocardium. Circ Res 66:1610-1623.
15. i proteins. Br J Pharmacol 138:1361-1369.
16. 1-adrenoceptors. Naunyn Schmiedeberg's Arch Pharmacol 367:380-390.
17. 2-adrenoceptor. Br J Pharmacol 133:73-82.
18. 3-adrenoceptor function in murine heart. Br J Pharmacol 136:217-229.
19. 2-adrenoceptor. Cardiovasc Res 42:173-182.
20. 2- adrenoceptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I and C protein in ventricular myocardium from patients with terminal heart failure. Circulation 99:65-72.
21. Kaumann AJ, Hall JA, Murray KJ, Wells FC, and Brown MJ (1989) A comparison of the effects of adrenaline and noradrenaline on human heart: the role of adenylate cyclase and contractile force. Eur Heart J 10 (Suppl B):29-37.
22. 2-adrenoceptor-mediated positive inotropic effects of adrenaline in human ventricular myocardium. Quantitative discrepancies between binding and adenylate cyclase stimulation. Naunyn Schmiedeberg's Arch Pharmacol 335:403-411.
23. 2-adrenoceptors. Pharmacol Commun 6:215-222.
24. Kenakin T (1995a) Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity. Trends Pharmacol Sci 16:188-192.
25. Kenakin T (1995b) Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
26. i. Circ Res 87:705-709.
27. 2-adrenergic receptor. Science (Wash DC) 264:582-586.
28. s-protein. Circulation 102:1814-1821.
29. Murray KJ, England PJ, Lynham JA, Mills D, Schmitz-Pfeiffer C, and Reeves ML (1990) Use of synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues. Biochem J 267:703-708.
30. 3- adrenoceptor function. Naunyn Schmiedeberg's Arch Pharmacol 361:134-145.
31. 2-adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem 279:686-691.
32. i proteins. Circ Res 87:635-637.
33. i proteins and its physiological relevance in murine cardiac myocytes. Circ Res 84:43-52.
34. 1-AR- mediated positive inotropic effect in myocytes from failing rat hearts. Circulation 108:1633-1639.
35. 2-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci USA 98:1607-1612.