A marine-derived Streptomyces sp. MS449 produces high yield of actinomycin X2 and actinomycin D with potent anti-Tuberculosis activity

Applied Microbiology and Biotechnology

Volumn 95, Issue 4, 2012, Pages 919-927

  Chen, Caixia ^a   Song, Fuhang ^a   Wang, Qian ^a   Abdel Mageed, Wael M ^a,b   Guo, Hui ^a   Fu, Chengzhang ^a   Hou, Weiyuan ^c   Dai, Huanqin ^a   Liu, Xueting ^a   Yang, Na ^a   Xie, Feng ^a   Yu, Ke ^a   Chen, Ruxian ^d   Zhang, Lixin ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b Assiut University   (Egypt)

^c Laboratory of Molecular Vector Biology   (China)

^d INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Actinomycins; Anti BCG; Anti Tuberculosis; Streptomyces avermitilis

Indexed keywords

16S RRNA GENE; 16S RRNA GENE SEQUENCE; ACTINOMYCIN D; ACTINOMYCINS; ANTI-BCG; ANTI-TUBERCULOSIS; DATABASE SEARCHES; HIGH YIELD; MASS SPECTROMETRIC ANALYSIS; MYCOBACTERIUM BOVIS; NATURAL PRODUCTS; PHYLOGENETIC ANALYSIS; SCREENING PROGRAMS; SEDIMENT SAMPLES; SOUTH CHINA SEA; STREPTOMYCES AVERMITILIS; STREPTOMYCES SP;

BACTERIA; BACTERIOLOGY; GENES; RNA; SEARCH ENGINES; TUBES (COMPONENTS);

STRAIN;

ACTINOMYCIN DERIVATIVE; ACTINOMYCIN X2; DACTINOMYCIN; ERYTHROMYCIN; GENTAMICIN; PENICILLIN G; RNA 16S; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; BACTERIUM; GENOTYPE; MARINE ENVIRONMENT; MARINE SEDIMENT; MORPHOLOGY; PHENOTYPE; PHYLOGENETICS; TAXONOMY; TUBERCULOSIS;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CHEMOTAXONOMY; CHINA; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; GENE EXPRESSION; GENE SEQUENCE; GENOTYPE; GROWTH INHIBITION; MARINE BACTERIUM; MASS SPECTROMETRY; MORPHOMETRICS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENY; SEDIMENT; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

ANTITUBERCULAR AGENTS; BASE SEQUENCE; CULTURE MEDIA; DACTINOMYCIN; DNA PRIMERS; FERMENTATION; MARINE BIOLOGY; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON, SCANNING; RNA, RIBOSOMAL, 16S; STREPTOMYCES;

PACIFIC OCEAN; SOUTH CHINA SEA;

MYCOBACTERIUM BOVIS; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES AVERMITILIS; STREPTOMYCES SP.;

EID: 84864601610     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4079-z     Document Type: Article

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