TEM-89 β-lactamase produced by a Proteus mirabilis clinical isolate: New complex mutant (CMT 3) with mutations in both TEM-59 (IRT-17) and TEM-3

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 12, 2001, Pages 3591-3594

  Neuwirth, C ^a   Madec, S ^a   Siebor, E ^a   Pechinot, A ^a   Duez, J M ^a   Pruneaux, M ^a   Fouchereau Peron, M ^a   Kazmierczak, A ^a   Labia, R ^a  

^a HÔPITAL DU BOCAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CEFALORIDINE; CEFALOTIN; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CLAVULANIC ACID; PENICILLIN DERIVATIVE; PENICILLIN G; PIPERACILLIN; SULBACTAM; TAZOBACTAM; TEM 89 BETA LACTAMASE; TICARCILLIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG HYDROLYSIS; ENZYME ANALYSIS; ENZYME SYNTHESIS; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEUS MIRABILIS;

AMINO ACID SUBSTITUTION; BETA-LACTAMASES; CONJUGATION, GENETIC; ESCHERICHIA COLI; HUMANS; ISOELECTRIC FOCUSING; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PROTEUS INFECTIONS; PROTEUS MIRABILIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035178731     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.12.3591-3594.2001     Document Type: Article

References (25)

1. A standard numbering scheme for the class A β-lactamases
2. Characterization of an inhibitor-resistant TEM (IRT) β-lactamase in a novel strain of Klebsiella pneumoniae
3. Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived β-lactamase in a clinical isolate of Klebsiella oxytoca
4. Rapid alkaline extraction procedure for screening recombinant plasmid DNA
5. Diversity of TEM mutants in Proteus mirabilis
6. Characterization of an inhibitor-resistant enzyme IRT-2 derived from TEM-2 β-lactamase produced by Proteus mirabilis strains
7. Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 β-lactamase genes
8. Implication of Ile-69 and Thr-182 residues in kinetic characteristics of IRT-3 (TEM·32) β-lactamase
9. A novel complex mutant β-lactamase, TEM·68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum β-lactamase-producing klebsiellae
10. T-2
11. Frequency of inhibitor-resistant TEM β-lactamases in Escherichia coli isolates from urinary tract infections in France
12. Molecular characterisation of nine different types of mutants among 107 inhibitorresistant TEM β-lactamases from clinical isolates of Escherichia coli
13. Extended broad-spectrum β-lactamases conferring transferable resistance to newer β-lactam agents in Enterobacteriaceae: Hospital prevalence and susceptibility patterns
14. Computerized microacidimetric determination of β-lactamase Michaelis-Menten constants
15. First characterization of inhibitor-resistant TEM (IRT) β-lactamases in Klebsiella pneumoniae strains
16. Replacement of lysine 234 affects transition state stabilization in the active site of β-lactamase TEM-1
17. Evidence of in vivo transfer of a plasmid encoding the extended-spectrum β-lactamase TEM-24 and other resistance factors among different members of the family Enterobacteriaceae
18. Inhibitor-resistant β-lactamases
19. Emergence of an inhibitor-resistant β-lactamase (SHV-10) derived from an SHV-5 variant
20. Transferable resistance to thirdgeneration cephalosporins in clinical isolates of Klebsiella pneumoniae: Identification of CTX-1, a novel β-lactamase
21. Clinical isolates of Escherichia coli producing multiple TEM mutants resistant to β-lactamase inhibitors
22. A complex mutant of TEM-1 β-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Eschenchia coli clinical isolate
23. Inhibitor-resistant OXY-2-derived β-lactamase produced by Klebsiella oxytoca
24. The TEM-3 β-lactamase, which hydrolyzes broad-spectrum cephalosporins, is derived from the TEM-2 penicillinase by two amino acid substitutions
25. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322