Non-linear pharmacokinetics of octaarginine-modified lipid nanoparticles: Barriers from in vitro to in vivo

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 757-762

  Hayashi, Yasuhiro ^a   Noguchi, Yuki ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

In vitro and in vivo; Nanoparticle; Octaarginine; Pharmacodynamics; Pharmacokinetics; siRNA

Indexed keywords

CULTURED CELL; DRUG DEVELOPMENT; IN-VITRO; IN-VIVO; LIPID NANOPARTICLES; MOUSE LIVER; NON-LINEARITY; OCTAARGININE; QUANTITATIVE STUDY; RATE-LIMITING STEPS; SIRNA; SIRNA DELIVERY;

MAMMALS; MOLECULES; PHARMACODYNAMICS; PHARMACOKINETICS;

NANOPARTICLES;

ARGININE; COMPLEMENTARY DNA; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; LIPID NANOPARTICLE; MESSENGER RNA; NANOPARTICLE; NUCLEIC ACID; OCTAARGININE; R8; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; FEMALE; GENE DELIVERY SYSTEM; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NONLINEAR SYSTEM; PHARMACODYNAMICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA INTERFERENCE;

ANIMALS; CELL LINE, TUMOR; FEMALE; GENE SILENCING; LIVER; MICE; MICE, INBRED C57BL; NANOPARTICLES; OLIGOPEPTIDES; PHOSPHATIDYLETHANOLAMINES; RNA, SMALL INTERFERING; STEARATES;

EID: 84864592256     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.036     Document Type: Article

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