A Method Using Active-Site Sequence Conservation to Find Functional Shifts in Protein Families: Application to the Enzymes of Central Metabolism, Leading to the Identification of an Anomalous Isocitrate Dehydrogenase in Pathogens

Proteins: Structure, Function and Genetics

Volumn 55, Issue 2, 2004, Pages 455-463

  Das, Rajdeep ^a   Gerstein, Mark ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Active site; Genome; Metabolic enzyme; Sequence variation

Indexed keywords

CYTOTOXIN; ENZYME; ISOCITRATE DEHYDROGENASE; LEUCINE; PROTEIN; TRICARBOXYLIC ACID;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CALCULATION; CITRIC ACID CYCLE; GENOME; METABOLISM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; YERSINIA PESTIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CITRIC ACID CYCLE; CONSERVED SEQUENCE; HUMANS; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE ALIGNMENT; SUCCINATE DEHYDROGENASE;

YERSINIA; YERSINIA PESTIS;

EID: 1842427449     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10639     Document Type: Article

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