MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 772-780

  Te Boekhorst, Bernard C M ^a   Jensen, Linda B ^b   Colombo, Stefano ^b   Varkouhi, Amir K ^c   Schiffelers, Raymond M ^c   Lammers, Twan ^c,d   Storm, Gert ^c   Nielsen, Hanne M ^b   Strijkers, Gustav J ^a   Foged, Camilla ^b   Nicolay, Klaas ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UTRECHT UNIVERSITY   (Netherlands)

^d RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Collagen antibody induced arthritis; MRI; PLGA; RNAi; siRNA; TNF

Indexed keywords

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY EFFECTS; ANTI-TUMORS; BONE MARROW; CARTILAGE DESTRUCTION; DISEASE PROGRESSION; DOSE-DEPENDENT; EFFICIENT TREATMENT; FEMORAL HEADS; IN-VITRO; IN-VIVO; JOINT EFFUSION; MEDICAL NEEDS; NECROSIS FACTORS; PLGA; PLGA NANOPARTICLES; RHEUMATOID ARTHRITIS; RNAI; SIRNA; SIRNA TREATMENT; SMALL INTERFERING RNA (SIRNA); SYNOVIAL JOINTS; SYSTEMIC INFLAMMATION; THERAPEUTIC EFFECTS;

ANTIBODIES; BONE; COLLAGEN; DISEASES; JOINTS (ANATOMY); MAGNETIC RESONANCE IMAGING; NANOPARTICLES; RNA;

DISEASE CONTROL;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; LIPOPOLYSACCHARIDE; NANOPARTICLE; POLYGLACTIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW EDEMA; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENCAPSULATION; FEMUR HEAD; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; JOINT EFFUSION; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PAW SCORING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; SCORING SYSTEM; TIBIA; TREATMENT OUTCOME;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BONE MARROW; CELL LINE; DRUG CARRIERS; FATTY ACIDS, MONOUNSATURATED; FEMUR; GENE SILENCING; LACTIC ACID; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED DBA; NANOPARTICLES; POLYGLYCOLIC ACID; QUATERNARY AMMONIUM COMPOUNDS; RNA, SMALL INTERFERING; TIBIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864590087     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.004     Document Type: Article

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