Silencing of proinflammatory genes targeted to peritoneal-residing macrophages using siRNA encapsulated in biodegradable microspheres

Biomaterials

Volumn 31, Issue 9, 2010, Pages 2627-2636

  Brunner, Tali ^a   Cohen, Smadar ^a   Monsonego, Alon ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Biodegradable microspheres; Immunomodulation; Macrophage; siRNA delivery

Indexed keywords

ACTIVE MOLECULES; CHRONIC INFLAMMATORY; CYTOCHALASIN B; DEGRADABILITY; IMMUNOMODULATION; IN-VITRO; IN-VIVO; PERITONEAL MACROPHAGE; POLY (D ,L-LACTIDE); PROINFLAMMATORY; PROOF OF CONCEPT; SIRNA DELIVERY; SIZE EXCLUSION; TARGET CELLS; THERAPEUTIC AGENTS;

ANTIGEN-ANTIBODY REACTIONS; BIOCOMPATIBILITY; MACROPHAGES; MICROSPHERES; ORGANIC POLYMERS;

RNA;

CD86 ANTIGEN; CYTOCHALASIN B; LIPOFECTAMINE; MICROSPHERE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENCAPSULATION; GENE SILENCING; IMMUNOMODULATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD86; BIOCOMPATIBLE MATERIALS; GENE SILENCING; INFLAMMATION MEDIATORS; INTRACELLULAR SPACE; LACTIC ACID; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; ORGAN SPECIFICITY; POLYETHYLENEIMINE; POLYMERS; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 74449092896     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.12.011     Document Type: Article

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