Bisphenol A binds to the local anesthetic receptor site to block the human Cardiac Sodium channel

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  O'Reilly, Andrias O ^a,b   Eberhardt, Esther ^a   Weidner, Christian ^a,c   Alzheimer, Christian ^a   Wallace, B A ^b   Lampert, Angelika ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c Bavarian Health and Food Safety Authority   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; LOCAL ANESTHETIC AGENT; MEXILETINE; SODIUM CHANNEL NAV1.5; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; BINDING COMPETITION; BINDING SITE; CARDIOTOXICITY; CRYSTAL STRUCTURE; HEART ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTAGENESIS; PATCH CLAMP; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANESTHETICS, LOCAL; BENZHYDRYL COMPOUNDS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; HEK293 CELLS; HUMANS; LIGANDS; MEMBRANE POTENTIALS; MEXILETINE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MYOCARDIUM; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PHENOLS; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS;

BACTERIA (MICROORGANISMS);

EID: 84864582044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041667     Document Type: Article

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