The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 26840-26853

  Spoerri, Loredana ^a,b   Vella, Laura J ^a,b,c   Pham, Chi L L ^a,b,d   Barnham, Kevin J ^a,b   Cappai, Roberto ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c AUSTIN HOSPITAL   (Australia)

^d University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; COPPER BINDING; COPPER BINDING SITE; COPPER HOMEOSTASIS; HEK293 CELLS; HISTIDINE RESIDUES; N-TERMINALS; PROTEOLYTIC PROCESSING; SECONDARY STRUCTURES; TERTIARY STRUCTURES; THERAPEUTIC DRUGS; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

CELL MEMBRANES; COPPER; GLYCOPROTEINS; METABOLISM; OLIGOMERIZATION; OLIGOMERS; PHYSIOLOGY; RECOMBINANT PROTEINS;

AMINO ACIDS;

AMYLOID PRECURSOR PROTEIN; ASPARAGINE; HISTIDINE; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; COPPER BINDING DOMAIN; EMBRYO; ENDOPLASMIC RETICULUM; GENE MUTATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; MUTANT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

AMYLOID BETA-PROTEIN PRECURSOR; BINDING SITES; CELL LINE; COPPER; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTIDINE; HUMANS; IMMUNOHISTOCHEMISTRY; MUTATION;

EID: 84864572336     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355743     Document Type: Article

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