Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: An ovine model of fetal unilateral nephrectomy

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Singh, Reetu R ^a,b   Jefferies, Andrew J ^a   Lankadeva, Yugeesh R ^a   Lombardo, Paul ^a   Schneider Kolsky, Michal ^a   Hilliard, Lucinda ^a   Denton, Kate M ^a   Moritz, Karen M ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; FETUS; FETUS SURGERY; FUNCTIONAL ASSESSMENT; GLOMERULONEPHRITIS; GLOMERULUS FILTRATION RATE; HEART FUNCTION TEST; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE SIZE; HIGH RISK POPULATION; HYPERTENSION; KIDNEY BLOOD FLOW; KIDNEY DYSFUNCTION; NEPHRON; NONHUMAN; ONSET AGE; RENAL RISK; RISK FACTOR; SHAM PROCEDURE; SHEEP; UNINEPHRECTOMY;

AGING; ANIMALS; ARTERIAL PRESSURE; BIRTH WEIGHT; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; COLLAGEN; DOBUTAMINE; ECHOCARDIOGRAPHY; FEMALE; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART FUNCTION TESTS; HEART RATE; HORMONES; IONS; KIDNEY; KIDNEY FUNCTION TESTS; MODELS, ANIMAL; NEPHRECTOMY; NEPHRONS; RENIN; RISK FACTORS; SHEEP; TIME FACTORS;

ANIMALIA; OVIS; OVIS ARIES;

EID: 84864572107     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042400     Document Type: Article

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