Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny

Journal of the American Society of Nephrology

Volumn 21, Issue 11, 2010, Pages 1891-1902

  Gray, Stephen P ^a   Denton, Kate M ^a   Cullen McEwen, Luise ^a   Bertram, John F ^a   Moritz, Karen M ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BONE MORPHOGENETIC PROTEIN 4; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR RECEPTOR; KERATINOCYTE GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN GFRALPHA1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; WNT11 PROTEIN; WNT4 PROTEIN;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GLOMERULUS FILTRATION RATE; HEART RATE; INDWELLING CATHETER; KIDNEY FUNCTION; MALE; MORPHOGENESIS; NEPHRON; NONHUMAN; ORGAN WEIGHT; POSTNATAL GROWTH; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; PROTEINURIA; RAT; SEX DIFFERENCE; URINARY EXCRETION; WEIGHT GAIN;

EID: 78149352588     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010040368     Document Type: Article

References (52)

1. WHO Department of Mental Health and Substance Abuse: Global Status Report on Alcohol: 2004, Geneva, Switzerland, 2004
2. Caetano R, Ramisetty-Mikler S, Floyd LR, McGrath C: The epidemiology of drinking among women of child-bearing age. Alcohol Clin Exp Res 30: 1023-1030, 2006
3. Nayak MB, Kaskutas LA: Risky drinking and alcohol use patterns in a national sample of women of childbearing age. Addiction 99: 1393-1402, 2004
4. Maier SE, West JR: Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat. Alcohol 23: 49-57, 2001
5. Young C, Olney JW: Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration. Neurobiol Dis 22: 548-554, 2006
6. Wang X, Gomutputra P, Wolgemuth DJ, Baxi, L: Effects of acute alcohol intoxication in the second trimester of pregnancy on development of the murine fetal lung. Am J Obstet Gynecol 197: 269.e1-269.e4, 2007
7. Gallo PV, Weinberg J: Organ growth and cellular development in ethanol-exposed rats. Alcohol 3: 261-267, 1986
8. Assadi FK, Manaligod JR, Fleischmann LE, Zajac CS: Effects of prenatal ethanol exposure on postnatal renal function and structure in the rat. Alcohol 8: 259-263, 1991
9. Gray SP, Kenna K, Bertram JF, Hoy WE, Yan EB, Bocking AD, Brien JF, Walker DW, Harding R, Moritz KM: Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep. Am J Physiol Regul Integr Comp Physiol 295: R568-R574, 2008
10. Turcotte LA, Aberle Ii NS, Norby FL, Wang GJ, Ren J: Influence of prenatal ethanol exposure on vascular contractile response in rat thoracic aorta. Alcohol 26: 75-81, 2002
11. Brenner BM, Garcia DL, Anderson S: Glomeruli and blood pressure: Less of one, more the other? Am J Hypertens 1: 335-347, 1988
12. Keller G, Zimmer G, Mall G, Ritz E, Amann K: Nephron number in patients with primary hypertension. N Engl J Med 348: 101-108, 2003 (Pubitemid 36056716)
13. Hoy WE, Hughson MD, Singh GR, Douglas-Denton R, Bertram JF: Reduced nephron number and glomerulomegaly in Australian Aborigines: A group at high risk for renal disease and hypertension. Kidney Int 70: 104-110, 2006
14. Clark AT, Bertram JF: Molecular regulation of nephron endowment. Am J Physiol Renal Physiol 276: F485-F497, 1999
15. Burrow CR: Regulatory molecules in kidney development. Pediat Nephrol 14: 240-253, 2000
16. Dressler GR: The cellular basis of kidney development. Annu Rev Cell Dev Biol 22: 509-529, 2006
17. Moritz KM, Wintour-Coghlan M, Black MJ, Bertram JF, Caruana, G: Morphological development of the mammalian kidney. Adv Anat Embryol Cell Biol 196: 1-78, 2008
18. Singh RR, Moritz KM, Bertram JF, Cullen-McEwen LA: Effects of dexamethasone exposure on rat metanephric development: In vitro and in vivo studies. Am J Physiol Renal Physiol 293: F548-F554, 2007
19. Tsai J, Floyd LR, Green PP, Boyle CA: Patterns and average volume of alcohol use among women of childbearing age. Matern Child Health J 11: 437-445, 2007
20. Ethen MK, Ramadhani TA, Scheuerle AE, Canfield MA, Wyszynski DF, Druschel CM, Romitti PA: Alcohol consumption by women before and during pregnancy. Matern Child Health J 13: 274-285, 2009
21. Vavrousek-Jakuba EM, Baker RA, Shoemaker WJ: Effect of Ethanol on Maternal and Offspring Characteristics: Comparison of Three Liquid Diet Formulations Fed During Gestation. Alcohol Clin Exp Res 15: 129-135, 1991
22. Knee DS, Sato AK, Uyehara CFT, Claybaugh JR: Prenatal exposure to ethanol causes partial diabetes insipidus in adult rats. Am J Physiol Regul Integr Comp Physiol 287: R277-R283, 2004
23. Moritz KM, Wintour EM: Functional development of the meso- and metanephros. Pediat Nephrol 13: 171-178, 1999
24. Wintour EM, Moritz KM, Johnson K, Ricardo S, Samuel CS, Dodic M: Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol 549: 929-935, 2003
25. Langley-Evans SC, Welham SJM, Jackson AA: Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 64: 965-974, 1999
26. Woods LL, Weeks DA, Rasch R: Programming of adult blood pressure by maternal protein restriction: Role of nephrogenesis. Kidney Int 65: 1339-1348, 2004
27. Wlodek ME, Mibus A, Tan A, Siebel AL, Owens JA, Moritz KM: Normal lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat. J Am Soc Nephrol 18: 1688-1696, 2007
28. Spohr HL, Willms J, Steinhausen HC: Prenatal alcohol exposure and long-term developmental consequences. Lancet 341: 907-910, 1993
29. Lan N, Yamashita A, Halpert AG, Ellis L, Yu WK, Viau V, Weinberg J: Prenatal ethnaol exposure alters the effects of gonadectomy on hypothalamic- pituitary-alcohol activity in male rats. J Neuroendocrinol 18: 672-684, 2006
30. Moritz KM, Singh RR, Probyn ME, Denton KM: Developmental programming of a reduced nephron endowment: More than just a baby's birth weight. Am J Physiol Renal Physiol 296: F1-F9, 2009
31. Walker KA, Caruana G, Bertram JF, McInnes KJ: Sexual dimorphism in mouse metanephroi exposed to 17β-estradiol in vitro. Nephron Exp Nephrol 111: e42-e50, 2009
32. Ortiz LA, Quan A, Weinberg A, Baum M: Effect of prenatal dexamethasone on rat renal development. Kidney Int 59: 1663-1669, 2001
33. Ortiz LA, Quan A, Zarzar F, Weinberg A, Baum, M: Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension 41: 328-334, 2003
34. Cullen-McEwen LA, Drago J, Bertram JF: Nephron endowment in glial cell line-derived neurotrophic factor (gdnf) heterozygous mice. Kidney Int 60: 31-36, 2001
35. Oxburgh L, Chu GC, Michael SK, Robertson EJ: TGFβ2 superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131: 4593-4605, 2004
36. Stark K, Vainio S, Vassileva G, McMahon AP: Epithelial transformation metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372: 679-683, 1994
37. Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP: Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 130: 3175-3185, 2003
38. Qiao J, Uzzo R, Obara-Ishihara T, Degenstein L, Fuchs E, Herzlinger D: FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development 126: 547-554, 1999
39. Hughson MD, Douglas-Denton R, Bertram JF, Hoy WE: Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States. Kidney Int 69: 671-678, 2006
40. Weinberg J, Sliwowska JH, Lan N, Hellemans KGC: Prenatal alcohol exposure: Foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome. J Neuroendocrinol 20: 470-488, 2008
41. Singh RR, Denton KM, Bertram JF, Jefferies AJ, Moritz KM: Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep. Clin Sci 118: 669-680, 2010
42. Vallon V: Tubuloglomerular feedback and the control of glomerular filtration rate. News Physiol Sci 18: 169-174, 2003
43. Ljubojevic M, Herak-Kramberger CM, Hagos Y, Bahn A, Endou H, Burckhardt G, Sabolic I: Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 287: F124-F138, 2004
44. Baylis C: Sexual dimorphism in the aging kidney: Differences in the nitric oxide system. Nat Rev Nephrol 5: 384-396, 2009
45. Baylis C, Harton P, Engels K: Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney. J Am Soc Nephrol 1: 875-881, 1990
46. Johnson RA, Freeman RH: Sustained hypertension in the rat induced by chronic blockade of nitric oxide production. Am J Hypertens 5: 919-922, 1992
47. Denton KM, Anderson WP: Intrarenal haemodynamic and glomerular responses to inhibition of nitric oxide formation in rabbits. J Physiol 475: 159-167, 1994
48. Parkington HC, Coleman HA, Wintour EM, Tare M: Prenatal alcohol exposure: implications for cardiovascular function in the fetus and beyond. Clin Exp Pharmacol Physiol 37: E91-E98, 2010
49. Bertram JF: Counting in the kidney. Kidney Int 59: 792-796, 2001
50. Zimanyi MA, Denton KM, Forbes JM, Thallas-Bonke V, Thomas MC, Poon F, Black MJ: A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products. Diabetologia 49: 801-810, 2006
51. Denton KM, Li M, Anderson WP, Whitworth JA: Glomerular hypertension and hyperfiltration in adrenocorticotrophin-induced hypertension in rats: The role of nitric oxide. J Hypertens 19: 327-334, 2001
52. Dickinson H, Walker DW, Wintour EM, Moritz K: Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. Am J Physiol Regul Integr Comp Physiol 292: R453-R461, 2007