Estrogen promotes microvascular pathology in female stroke-prone spontaneously hypertensive rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 285, Issue 1 48-1, 2003, Pages

  Stier Jr , Charles T ^a   Chander, Praveen N ^a   Rosenfeld, Louis ^a   Powers, C Andrew ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Hypertension; Ovariectomy; Proteinuria; Renal microangiopathy; Tamoxifen

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; ANTIESTROGEN; ESTRADIOL BENZOATE; ESTROGEN; SODIUM CHLORIDE; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN ACTIVITY; FEMALE; GLOMERULOPATHY; HYPERTENSION; KIDNEY CIRCULATION; MICROANGIOPATHY; MICROVASCULATURE; NEPHROSCLEROSIS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL;

EID: 0038001536     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00029.2003     Document Type: Article

References (36)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, and Hurn PD. Gender-linked brain injury in experimental stroke. Stroke 29: 159-166, 1998.
2. Bracamonte MP and Miller VM. Vascular effects of estrogens: arterial protection versus venous thrombotic risk. Trends Endocrinol Metab 12: 204-209, 2001.
3. Carswell HVO, Dominiczak AF, and Macrae IM. Estrogen status affects sensitivity to focal cerebral ischemia in strokeprone spontaneously hypertensive rats. Arn J Physiol Heart Circ Physiol 278: H290-H294, 2000.
4. Cid MC, Schnaper HW, and Kleinman HK. Estrogens and the vascular endothelium. Ann NY Acad Sci 966: 143-157, 2002.
5. Cushman M. Effects of hormone replacement therapy and estrogen receptor modulators on markers of inflammation and coagulation. Am J Cardiol 90, Suppl: 7F-10F, 2002.
6. DiPippo VA, Lindsay R, and Powers CA. Estradiol and tamoxifen interactions with thyroid hormone in the ovariectomized-thyroidectomized rat. Endocrinology 136: 1020-1033, 1995.
7. Foegh ML and Ramwell PW. Cardiovascular effects of estrogen: implications of the discovery of the estrogen receptor subtype beta. Curr Opin Nephrol Hypertens 52: 83-89, 1998.
8. Gillum LA, Mamidipudi SK, and Johnston SC. Ischemic stroke risk with oral contraceptives. A meta-analysis. J Am Med Assoc 284: 72-78, 2000.
9. Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N, and Research Group HERS. Cardiovascular disease outcomes during 6.8 years of hormone replacement therapy: heart and estrogen/progestin replacement study follow-up (HERS II). J Am Med Assoc 288: 49-57, 2002.
10. Hernandez NE, MacDonall JS, Stier CT Jr, Belmonte A, Fernandez R, and Karpiak SE. GM1 ganglioside treatment of spontaneously hypertensive stroke prone rats. Exp Neurol 126: 95-100, 1994.
11. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, and Vittinghoff E for the HERS Research Group. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. J Am Med Assoc 280: 605-613, 1998.
12. Jazin EE, Dickerman HW, and Henrikson KP. Estrogen regulation of a tissue factor-like procoagulant in the immature rat uterus. Endocrinology 126: 176-185, 1990.
13. Joles JA, van Goor H, and Koomans HA. Estrogen induces glomerulosclerosis in analbuminemic rats. Kidney Int 53: 862-868, 1998.
14. MacGregor EA. Migraine and female hormones - what factors increase the risk of ischemic stroke? Vasc Med 5: 133-134, 2000.
15. Medlock KL, Forrester TM, and Sheehan DM. Short-term effects of physiological and pharmacological doses of estradiol on estrogen receptor and uterine growth. J Recept Res 11: 743-756, 1991.
16. Nagaoka A, Iwatsuka H, Suzuoki Z, and Okamoto K. Genetic predisposition to stroke in spontaneously hypertensive rats. Am J Physiol 230: 1354-1359, 1976.
17. Nakamura M, Ikeda Y, Mine M, Tomiyoshi Y, and Sakemi T. Somatostatin analogue attenuates estrogen-induced augmentation of glomerular injury in spontaneous hypercholesterolemic female Imai rats. Nephron 89: 448-454, 2001.
18. Okamoto K, Yamori Y, and Nagaoka A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 34 & 35: I-143-I-153, 1974.
19. Owens MR and Cimino CD. Diethylstilbestrol selectively modulates plasma coagulation protein synthesis by the perfused rat liver. Blood 66: 402-406, 1985.
20. Powers CA, Hatala MA, and Pagano PJ. Differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. Mol Cell Endocrinol 66: 93-100, 1989.
21. Rocha R, Chander PN, Khanna K, Zuckerman A, and Stier CT Jr. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 31: 451-458, 1998.
22. Rocha R and Funder JW. The pathophysiology of aldosterone in the cardiovascular system. Ann NY Acad Sci 970: 89-100, 2002.
23. Rocha R, Stier CT Jr, Kifor I, Ochoa-Maya MR, Rennke HG, Williams GH, and Adler GK. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology 141: 3871-3878, 2000.
24. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, and Hennekens CH. Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow up from the Nurses Health Study. New Engl J Med 325: 756-762, 1991.
25. Stevenson FT, Wheeldon CM, Gades MD, Kaysen GA, Stern JS, and van Goor H. Oestrogen worsens incipient hypertriglyceridemic glomerular injury in the obese Zucker rat. Kidney Int 57: 1927-1935, 2000.
26. Stier CT, Adler LA, Levine S, and Chander PN. Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats. J Hypertension 11, Suppl 3: S37-S42, 1993.
27. Stier CT Jr, Benter IF, Ahmad S, Zuo H, Selig N, Roethel S, Levine S, and Itskovitz HD. Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats. Hypertension 13: 115-121, 1989.
28. Stier CT Jr, Chander PN, Gutstein WH, Levine S, and Itskovitz HD. Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect. Am J Hypertens 4: 680-687, 1991.
29. Sugimoto T, Tobian L, and Ganguli MC. High potassium protects against dysfunction of endothelial cells in stroke prone spontaneously hypertensive rats. Hypertension 11: 579-585, 1988.
30. Wexler B. Enovid-induced exacerbation of high blood pressure in stroke-prone rats (SHR). Stroke 12: 101-105, 1981.
31. Wexler B. Enovid-induced exacerbation of the propensity for stroke in low protein fish diet-fed stroke-prone/SHR. Stroke 14: 995-1000, 1983.
32. Wu WM, Lin BF, Su YC, Suen JL, and Chiang BL. Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand J Immunol 52: 393-400, 2000.
33. Yamori Y, Horie R, Handa H, Sato M, and Fukase M. Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans. Stroke 7: 46-53, 1976.
34. Yamori Y, Horie R, Sato M, and Ohta K. Prophylactic trials for stroke in stroke-prone SHR: effect of sex hormones. Jpn Heart J 17: 404-406, 1976.
35. Yamori Y, Horie R, Tanase H, Fujiwara K, Nara Y, and Lovenberg W. Possible role of nutritional factors in the incidence of cerebral lesions in stroke-prone spontaneously hypertensive rats. Hypertension 6: 49-53, 1984.
36. Yamori Y, Nagaoka A, and Okamoto K. Importance of genetic factors in stroke: evidence obtained by selective breeding of stroke-prone and -resistant SHR. Jpn Circ J 38: 1095-1100, 1974.