Proteomic characterization of the possible molecular targets of pyrrolizidine alkaloid isoline-induced hepatotoxicity

Environmental Toxicology and Pharmacology

Volumn 34, Issue 2, 2012, Pages 608-617

  Wang, Zai Yong ^a,b   Kang, Hong ^c   Ji, Li Li ^a,b   Yang, Yong Qing ^a   Liu, Tian Yu ^a   Cao, Zhi Wei ^c   Morahan, Grant ^d   Wang, Zheng Tao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c TONGJI UNIVERSITY   (China)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Isoline; Liver injury; Oxidative stress; Proteomics; Pyrrolizidine alkaloids

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACETYL COENZYME A THIOESTERASE 2; ADENOSINE TRIPHOSPHATASE; ALANINE AMINOTRANSFERASE; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1; ASPARTATE AMINOTRANSFERASE; CARNITINE O PALMITOYLTRANSFERASE 2; CARNITINE PALMITOYLTRANSFERASE; FLAVIN REDUCTASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE P1; GLYCINE METHYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOLINE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; NICOTINATE NUCLEOTIDE PYROPHOSPHORYLASE (CARBOXYLATING); OXIDOREDUCTASE; PHOSPHORIBOSYLTRANSFERASE; PROBABLE OXIDOREDUCTASE 0610038K03RIK; PROTEIN ETHE1; PYRROLIZIDINE ALKALOID; TRIFUNCTIONAL ENZYME ALPHA SUBUNIT; UNCLASSIFIED DRUG; 3 HYDROXYACYL COENZYME A DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE II; ETHE1 PROTEIN; PROBABLE OXIDOREDUCTASE; PROTEIN; PYRROLIZIDINE ALKALOID ISOLINE; QUINOLATE PHOSPHORIBOSYLTRANSFERASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ENERGY; CHEMICAL STRUCTURE; CHINESE HERB; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; LD 50; LIGULARIA DUCIFORMIS; LIPID PEROXIDATION; LIVER TOXICITY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR DOCKING; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; PROTEOMICS; ENZYME ASSAY; LIVER; PATHOLOGY; SAMPLE; TWO DIMENSIONAL ELECTROPHORESIS; ANIMAL; ASTERACEAE; BLOOD; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; TOXIC HEPATITIS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

LIGULARIA DUCIFORMIS; MUS;

ADENOSINE TRIPHOSPHATASES; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; ASTERACEAE; DRUG-INDUCED LIVER INJURY; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED ICR; PROTEOMICS; PYRROLIZIDINE ALKALOIDS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84864569270     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2012.06.013     Document Type: Article

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