Diabetic CVD - focus on vitamin D

Cardiovascular and Hematological Agents in Medicinal Chemistry

Volumn 10, Issue 3, 2012, Pages 241-250

  Bonakdaran, Shokoufeh ^a   Rokni, Haleh ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Albuminuria; Cardiovascular Disease; Congestive heart failure; Diabetes; Hypertension; Inflammation; Insulin resistance; Metabolic Syndrome; Obesity; Vitamin D

Indexed keywords

VITAMIN D;

ALBUMINURIA; BLOOD PRESSURE; BLOOD VESSEL CALCIFICATION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CARDIOVASCULAR SYSTEM; DIABETES MELLITUS; DISEASE ASSOCIATION; GLUCOSE BLOOD LEVEL; HEART MUSCLE CELL; HUMAN; INFLAMMATION; INSULIN RELEASE; INSULIN RESISTANCE; METABOLIC SYNDROME X; NONHUMAN; OBESITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; VITAMIN D DEFICIENCY; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

EID: 84864559589     PISSN: 18715257     EISSN: 18756182     Source Type: Journal    
DOI: 10.2174/187152512802651088     Document Type: Review

References (111)

1. Bell, D.S. Diabetes: a cardiac condition manifesting as hyperglycemia. Endocr. Pract., 2008. 14(7), 924-932.
2. Lee, J.H.; O'Keefe, J.H.; Bell, D.; Hensrud, D.D.; Holick, M.F. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J. Am. Coll. Cardiol., 2008, 52(24), 1949-1956.
3. Holick, M.F. Vitamin D deficiency. N. Engl. J. Med., 2007, 357(3), 266-81.
4. Rosen, C.J. Clinical practice. Vitamin D insufficiency. N. Engl. J. Med., 2011, 364(3), 248-254.
5. Binkley, N.; Novotny, R.; Krueger, D.; Kawahara, T.; Daida, Y.G.; Lensmeyer, G.; Hollis, B.W.; Drezner, M.K. Low vitamin D status despite abundant sun exposure. J. Clin. Endocrinol. Metab., 2007, 92(6), 2130-2135.
6. Binkley, N.; Krueger, D.; Lensmeyer, G. 25-hydroxyvitamin D measurement, 2009: a review for clinicians. J. Clin. Densitom, 2009, 12(4), 417-427.
7. Thacher, T.D.; Clarke, B.L. Vitamin D insufficiency. Mayo Clin. Proc., 2011, 86(1), 50-60.
8. Miller, P.D. Vitamin d, calcium, and cardiovascular mortality: a perspective from a plenary lecture given at the annual meeting of the american association of clinical endocrinologists. Endocr. Pract., 2011, 17(5), 798-806.
9. Awumey, E.M.K.; Mitra, D.A.; Hollis, B.W.; Kumar, R.; Bell, N.H. Vitamin D metabolism is altered in Asian Indians in the southern United States: a clinical research center study. J. Clin. Endocrinol. Metab., 1998, 83(1), 169.
10. Binkley, N.; Ramamurthy, R.; Krueger, D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol. Metab. Clin. North Am., 2010, 39(2), 287-301, table of contents.
11. Watson, K.E.; Abrolat, M.L.; Malone, L.L.; Hoeg, J.M.; Doherty, T.; Detrano, R.; Demer, L.L. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation, 1997, 96(6), 1755-1760.
12. Young, K.A.; Snell-Bergeon, J.K.; Naik, R.G.; Hokanson, J.E.; Tarullo, D.; Gottlieb, P.A.; Garg, S.K.; Rewers, M. Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. Diabetes Care, 2011, 34(2), 454-458.
13. Barengolts, E.I.; Berman, M.; Kukreja, S.C.; Kouznetsova, T.; Lin, C.; Chomka, E.V. Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif. Tissue Int., 1998, 62(3), 209-213.
14. Merke, J.; Milde, P.; Lewicka, S.; Hugel, U.; Klaus, G.; Mangelsdorf, D.J.; Haussler, M.R.; Rauterberg, E.W.; Ritz, E. Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. J. Clinc. Invest., 1989, 83(6),1903-15.
15. Pearson, T.A.; Mensah, G.A.; Alexander, R.W.; Anderson, J.L.; Cannon, R.O.; Criqui, M.; Fadl, Y.Y.; Fortmann, S.P.; Hong, Y.; Myers, G.L. Markers of inflammation and cardiovascular disease. Circulation, 2003, 107(3), 499.
16. Mathieu, C.; Adorini, L. The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol. Med., 2002, 8(4), 174-179.
17. Timms, P.; Mannan, N.; Hitman, G.; Noonan, K.; Mills, P. Circulating MMP9, vitamin D and variation in the TIMP 1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM, 2002, 95(12), 787-796.
18. Talmor, Y.; Bernheim, J.; Klein, O.; Green, J.; Rashid, G. Calcitriol blunts pro atherosclerotic parameters through NF B and p38 in vitro. Eur. J. Clin. Invest., 2008, 38(8), 548-554.
19. Zittermann, A.; Koerfer, R. Protective and toxic effects of vitamin D on vascular calcification: Clinical implications. Mol. Aspects Med., 2008, 29(6), 423-432.
20. Wu-Wong, J.R.; Nakane, M.; Ma, J.; Ruan, X.; Kroeger, P.E. Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells. Atherosclerosis, 2006, 186(1), 20-28.
21. Nibbelink, K.A.; Tishkoff, D.X.; Hershey, S.D.; Rahman, A.; Simpson, R.U. 1, 25 (OH) 2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte. J. Steroid Biochem. Mol. Biol., 2007, 103(3-5), 533-537.
22. Zittermann, A.; Schleithoff, S.S.; Tenderich, G.; Berthold, H.K.; Körfer, R.; Stehle, P. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?* 1. J. Am. Coll. Cardiol., 2003, 41(1), 105-112.
23. Achinger, S.G.; Ayus, J.C. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int. Suppl., 2005, (95), S37-42.
24. O'Connell, T.D.; Berry, J.E.; Jarvis, A.; Somerman, M.; Simpson, R. 1, 25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am. J. Physiol. Heart Circ. Physiol., 1997, 272(4), H1751-H1758.
25. Li, Y.C.; Kong, J.; Wei, M.; Chen, Z.F.; Liu, S.Q.; Cao, L.P. 1, 25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest., 2002, 110(2), 229-238.
26. Judd, S.E.; Tangpricha, V. Vitamin d therapy and cardiovascular health. Curr. Hypertens. Rep., 2011, 13(3), 187-191.
27. Doughan, A.K.; Harrison, D.G.; Dikalov, S.I. Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ. Res., 2008, 102(4), 488-496.
28. Park, C.W.; Oh, Y.S.; Shin, Y.S.; Kim, C.M.; Kim, Y.S.; Kim, S.Y.; Choi, E.J.; Chang, Y.S.; Bang, B.K. Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism. Am. J. Kidney Dis., 1999, 33(1), 73-81.
29. Cosenso-Martin, L.N.; Vilela-Martin, J.F. Is there an association between vitamin D and hypertension? Recent Pat. Cardiovasc. Drug. Discov., 2011, 6(2), 140-147.
30. Witham, M.D.; Nadir, M.A.; Struthers, A.D. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J. Hypertens., 2009, 27(10), 1948-54.
31. Judd, S.E.; Nanes, M.S.; Ziegler, T.R.; Wilson, P.W.; Tangpricha, V. Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. Am. J. Clin. Nutr., 2008, 87(1), 136-41.
32. Forman, J.P.; Bischoff-Ferrari, H.A.; Willett, W.C.; Stampfer, M.J.; Curhan, G.C. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension, 2005, 46(4), 676-682
33. Forman, J.P.; Giovannucci, E.; Holmes, M.D.; Bischoff-Ferrari, H.A.; Tworoger, S.S.; Willett, W.C.; Curhan, G.C. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension, 2007, 49(5), 1063-1069.
34. Wang, T.J.; Pencina, M.J.; Booth, S.L.; Jacques, P.F.; Ingelsson, E.; Lanier, K.; Benjamin, E.J.; D'Agostino, R.B.; Wolf, M.; Vasan, R.S. Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008, 117(4), 503-511.
35. Stewart, M.W.; Laker, M.F.; Dyer, R.G.; Game, F.; Mitcheson, J.; Winocour, P.H.; Alberti, K.G. Lipoprotein compositional abnormalities and insulin resistance in type II diabetic patients with mild hyperlipidemia. Arterioscler. Thromb., 1993, 13(7), 1046-1052.
36. Steinberg, H.O.; Paradisi, G.; Hook, G.; Crowder, K.; Cronin, J.; Baron, A.D. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes, 2000, 49(7), 1231-1238.
37. Masuo, K.; Mikami, H.; Itoh, M.; Ogihara, T.; Tuck, M.L. Sympathetic activity and body mass index contribute to blood pressure levels. Hypertens. Res., 2000, 23(4), 303-310.
38. Hess, K.; Grant, P.J. Inflammation and thrombosis in diabetes. Thromb. Haemost., 2011, 105(Suppl. 1), S43-54.
39. Kaye, S.M.; Pietiläinen, K.H.; Kotronen, A.; Joutsi-Korhonen, L.; Kaprio, J.; Yki-Järvinen, H.; Silveira, A.; Hamsten, A.; Lassila, R.; Rissanen, A. Obesity-Related Derangements of Coagulation and Fibrinolysis & colon; A Study of Obesity-Discordant Monozygotic Twin Pairs. Obesity, 2011. [Epub ahead of print]
40. Pittas, A.G.; Lau, J.; Hu, F.; Dawson-Hughes, B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J. Clin. Endocrinol. Metabol. 2007, 92(6), 2017-2029.
41. Ozfirat, Z.; Chowdhury, T.A. Vitamin D deficiency and type 2 diabetes. Postgrad. Med. J., 2010, 86(1011), 18-25.
42. Danescu, L.G.; Levy, S.; Levy, J. Vitamin D and diabetes mellitus. Endocrine, 2009, 35(1), 11-17.
43. Kulie, T.; Groff, A.; Redmer, J.; Hounshell, J.; Schrager, S. Vitamin D: an evidence-based review. J. Am. Board. Fam. Med., 2009, 22(6), 698-706.
44. Kayaniyil, S.; Vieth, R.; Retnakaran, R.; Knight, J.A.; Qi, Y.; Gerstein, H. C.; Perkins, B.A.; Harris, S.B.; Zinman, B.; Hanley, A.J. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care, 2010, 33(6), 1379-1381
45. Norman, A.W. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am. J. Clin. Nutr., 2008, 88(2), 491S-499S
46. Procopio, M.; Magro, G.; Cesario, F.; Piovesan, A.; Pia, A.; Molineri, N.; Borretta, G. The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed Type 2 diabetes mellitus in primary hyperparathyroidism. Diabet. Med., 2002, 19(11), 958-961.
47. Draznin, B.; Lewis, D.; Houlder, N.; Sherman, N.; Adamo, M.; Garvey, W.T.; LeRoith, D.; Sussman, K. Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes. Endocrinology, 1989, 125(5), 2341-2349.
48. Cavalier, E.; Delanaye, P.; Souberbielle, J.C.; Radermecker, R.P. Vitamin D and type 2 diabetes mellitus: Where do we stand? Diabetes Metab., 2011, 37(4), 265-272.
49. Mathieu, C.; Gysemans, C.; Giulietti, A.; Bouillon, R. Vitamin D and diabetes. Diabetologia, 2005, 48(7), 1247-1257.
50. Mitri, J.; Muraru, M.D.; Pittas, A.G. Vitamin D and type 2 diabetes: a systematic review. Eur. J. Clin. Nutr., 2011, 65(9), 1005-1015.
51. Maxwell, C.S.; Wood, R.J. Update on vitamin D and type 2 diabetes. Nutr. Rev., 2011, 69(5), 291-295.
52. Mattila, C.; Knekt, P.; Mannisto, S.; Rissanen, H.; Laaksonen, M.A.; Montonen, J.; Reunanen, A. Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care, 2007, 30(10), 2569-2570.
53. Forouhi, N.G.; Luan, J.; Cooper, A.; Boucher, B.J.; Wareham, N.J. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes, 2008, 57(10), 2619-2625
54. Nagpal, J.; Pande, J.N.; Bhartia, A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middleaged, centrally obese men. Diabet. Med., 2009, 26(1), 19-27.
55. Pittas, A.G.; Harris, S.S.; Stark, P.C.; Dawson-Hughes, B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care, 2007, 30(4), 980-986.
56. Palomer, X.; Gonzalez-Clemente, J.M.; Blanco-Vaca, F.; Mauricio, D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes. Metab., 2008, 10(3), 185-197.
57. Fliser, D.; Stefanski, A.; Franek, E.; Fode, P.; Gudarzi, A.; Ritz, E. No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects. Eur. J. Clin. Invest., 1997, 27(7), 629-633.
58. Zittermann, A.; Frisch, S.; Berthold, H.K.; Gotting, C.; Kuhn, J.; Kleesiek, K.; Stehle, P.; Koertke, H.; Koerfer, R. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am. J. Clin. Nutr., 2009, 89(5), 1321-1327.
59. Webb, A.R.; Kline, L.; Holick, M.F. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J. Clin. Endocrinol. Metab., 1988, 67(2), 373-378.
60. Karvonen, M.; Jantti, V.; Muntoni, S.; Stabilini, M.; Stabilini, L.; Tuomilehto, J. Comparison of the seasonal pattern in the clinical onset of IDDM in Finland and Sardinia. Diabetes Care, 1998, 21(7), 1101-1109.
61. Zipitis, C.S.; Akobeng, A.K. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch. Dis. Child., 2008, 93(6), 512-517.
62. Fronczak, C.M.; Baron, A.E.; Chase, H.P.; Ross, C.; Brady, H.L.; Hoffman, M.; Eisenbarth, G. S.; Rewers, M.; Norris, J.M. In utero dietary exposures and risk of islet autoimmunity in children. Diabetes Care, 2003, 26(12), 3237-3242.
63. Hypponen, E. Vitamin D and increasing incidence of type 1 diabetes-evidence for an association? Diabetes Obes. Metab., 2010, 12(9), 737-743.
64. Bogers, R.P.; Bemelmans, W.J.; Hoogenveen, R.T.; Boshuizen, H.C.; Woodward, M.; Knekt, P.; van Dam, R.M.; Hu, F.B.; Visscher, T.L.; Menotti, A.; Thorpe, R.J. Jr.; Jamrozik, K.; Calling, S.; Strand, B.H.; Shipley, M.J. Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including more than 300 000 persons. Arch. Intern. Med., 2007, 167(16), 1720-1728.
65. McGill, A.T.; Stewart, J.M.; Lithander, F.E.; Strik, C.M.; Poppitt, S.D. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J 2008, 7, 4.
66. Ford, E.S.; Zhao, G.; Li, C.; Pearson, W.S. Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States. J. Diabetes, 2009, 1(4), 296-303.
67. Grethen, E.; McClintock, R.; Gupta, C.E.; Jones, R.; Cacucci, B.M.; Diaz, D.; Fulford, A.D.; Perkins, S.M.; Considine, R.V.; Peacock, M. Vitamin D and hyperparathyroidism in obesity. J. Clin. Endocrinol. Metab., 2011, 96(5), 1320-1326.
68. Adam, M.A.; Untch, B.R.; Danko, M.E.; Stinnett, S.; Dixit, D.; Koh, J.; Marks, J.R.; Olson, J.A. Jr. Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism. J. Clin. Endocrinol. Metab., 2010, 95(11), 4917-4924.
69. Reis, J.P.; von Muhlen, D.; Miller, E.R. 3rd. Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur. J. Endocrinol., 2008, 159(1), 41-48.
70. Reis, J.P.; von Muhlen, D.; Kritz-Silverstein, D.; Wingard, D.L.; Barrett-Connor, E. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care, 2007, 30(6), 1549-1555.
71. Hjelmesaeth, J.; Hofso, D.; Aasheim, E.T.; Jenssen, T.; Moan, J.; Hager, H.; Roislien, J.; Bollerslev, J. Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study. Cardiovasc. Diabetol., 2009, 8, 7.
72. Schwarz, U.; Amann, K.; Orth, S.R.; Simonaviciene, A.; Wessels, S.; Ritz, E. Effect of 1,25 (OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats. Kidney Int., 1998, 53(6), 1696-1705.
73. Kuhlmann, A.; Haas, C.S.; Gross, M.L.; Reulbach, U.; Holzinger, M.; Schwarz, U.; Ritz, E.; Amann, K. 1, 25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am. J. Physiol. Renal Physiol., 2004, 286(3), F526-533.
74. Tan, X.; Li, Y.; Liu, Y. Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis. J. Steroid Biochem. Mol. Biol., 2007, 103(3-5), 491-496.
75. Tian, J.; Liu, Y.; Williams, L.A.; de Zeeuw, D. Potential role of active vitamin D in retarding the progression of chronic kidney disease. Nephrol. Dial. Transplant., 2007, 22(2), 321-328.
76. de Boer, I.H.; Ioannou, G.N.; Kestenbaum, B.; Brunzell, J.D.; Weiss, N.S. 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III). Am. J. Kidney Dis., 2007, 50(1), 69-77.
77. Alborzi, P.; Patel, N.A.; Peterson, C.; Bills, J.E.; Bekele, D.M.; Bunaye, Z.; Light, R.P.; Agarwal, R. Paricalcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial. Hypertension, 2008, 52(2), 249-255.
78. Fiscella, K.A.; Winters, P.C.; Ogedegbe, G. Vitamin D and Racial Disparity in Albuminuria: NHANES 2001-2006. Am. J. Hypertens., 2011, 24(10), 1114-1120.
79. Isakova, T.; Gutiérrez, O.M.; Patel, N.M.; Andress, D.L.; Wolf, M.; Levin, A. Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions. J. Ren. Nutr., 2011, 21(4), 295-302.
80. Agarwal, R.; Acharya, M.; Tian, J.; Hippensteel, R.L.; Melnick, J.Z.; Qiu, P.; Williams, L.; Batlle, D. Antiproteinuric effect of oral paricalcitol in chronic kidney disease. Kidney Int., 2005, 68(6), 2823-2828.
81. Masuda, S.; Jones, G. Promise of vitamin D analogues in the treatment of hyperproliferative conditions. Mol. Cancer Therap., 2006, 5(4), 797-808.
82. Dusso, A.S.; Brown, A.J.; Slatopolsky, E. Vitamin D. Am. J. Physiol. Renal Physiol., 2005, 289(1), F8-28.
83. Lambers Heerspink, H.J.; Agarwal, R.; Coyne, D.W.; Parving, H.H.; Ritz, E.; Remuzzi, G.; Audhya, P.; Amdahl, M.J.; Andress, D.L.; de Zeeuw, D. The selective vitamin D receptor activator for albuminuria lowering (VITAL) study: study design and baseline characteristics. Am. J. Nephrol. 2009, 30(3), 280-286.
84. de Zeeuw, D.; Agarwal, R.; Amdahl, M.; Audhya, P.; Coyne, D.; Garimella, T.; Parving, H.H.; Pritchett, Y.; Remuzzi, G.; Ritz, E.; Andress, D. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet, 2010, 376(9752), 1543-1551.
85. Zhang, Z.; Zhang, Y.; Ning, G.; Deb, D.K.; Kong, J.; Li, Y.C. Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase. Proc. Natl. Acad. Sci. USA, 2008, 105(41), 15896-15901.
86. Lund, B.; Badskjaer, J.; Soerensen, O.H. Vitamin D and ischaemic heart disease. Horm. Metab. Res., 1978, 10(6), 553-556.
87. Anonymous plan and operation of third national health and nutrition examination survey,-.s.o.p.a.c.p. vital and health statistics. vital health stat 1, 1994, 32.
88. Kilkkinen, A.; Knekt, P.; Aro, A.; Rissanen, H.; Marniemi, J.; Heliövaara, M.; Impivaara, O.; Reunanen, A. Vitamin D status and the risk of cardiovascular disease death. Am. J. Epidemiol., 2009, 170(8), 1032-1039.
89. Hutchinson, M.S.; Grimnes, G.; Joakimsen, R.M.; Figenschau, Y.; Jorde, R. Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromsø study. Eur. J. Endocrinol., 2010, 162(5), 935-942.
90. Dobnig, H.; Pilz, S.; Scharnagl, H.; Renner, W.; Seelhorst, U.; Wellnitz, B.; Kinkeldei, J.; Boehm, B.O.; Weihrauch, G.; Maerz, W. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch. Intern. Med., 2008, 168(12), 1340-1349.
91. Pilz, S.; Marz, W.; Wellnitz, B.; Seelhorst, U.; Fahrleitner-Pammer, A.; Dimai, H.P.; Boehm, B.O.; Dobnig, H. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J. Clin. Endocrinol. Metab., 2008, 93(10), 3927-3935.
92. Michaelsson, K.; Baron, J.A.; Snellman, G.; Gedeborg, R.; Byberg, L.; Sundstrom, J.; Berglund, L.; Arnlov, J.; Hellman, P.; Blomhoff, R.; Wolk, A.; Garmo, H.; Holmberg, L.; Melhus, H. Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am. J. Clin. Nutr., 2010, 92(4), 841-848.
93. Leu, M.; Giovannucci, E. Vitamin D: epidemiology of cardiovascular risks and events. Best Pract. Res. Clin. Endocrinol. Metab., 2011, 25(4), 633-646.
94. Marniemi, J.; Alanen, E.; Impivaara, O.; Seppanen, R.; Hakala, P.; Rajala, T.; Ronnemaa, T. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Nutr. Metab. Cardiovasc. Dis., 2005, 15(3), 188-197.
95. Melamed, M.L.; Muntner, P.; Michos, E.D.; Uribarri, J.; Weber, C.; Sharma, J.; Raggi, P. Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004. Arterioscler. Thromb. Vasc. Biol., 2008, 28(6), 1179-1185.
96. Kendrick, J.; Targher, G.; Smits, G.; Chonchol, M. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis, 2009, 205(1), 255-260.
97. Zittermann, A.; Schleithoff, S.S.; Koerfer, R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br. J. Nutr., 2005, 94(4), 483-492.
98. Levin, A.; Li, Y.C. Vitamin D and its analogues: do they protect against cardiovascular disease in patients with kidney disease? Kidney Int., 2005, 68(5), 1973-1981.
99. Cawthon, P.M.; Parimi, N.; Barrett-Connor, E.; Laughlin, G.A.; Ensrud, K.E.; Hoffman, A.R.; Shikany, J.M.; Cauley, J.A.; Lane, N.E.; Bauer, D.C.; Orwoll, E.S.; Cummings, S.R. Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men. J. Clin. Endocrinol. Metab., 2010, 95(10), 4625-4634.
100. Bonakdaran, S.; Varasteh, A.R. Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients. Saudi Med. J., 2009, 30(4), 509-514.
101. Pilz, S.; Dobnig, H.; Fischer, J.E.; Wellnitz, B.; Seelhorst, U.; Boehm, B.O.; März, W. Low vitamin D levels predict stroke in patients referred to coronary angiography. Stroke, 2008, 39(9), 2611-2613.
102. Giovannucci, E.; Liu, Y.; Hollis, B.W.; Rimm, E.B. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch. Intern. Med., 2008, 168(11), 1174-1180.
103. Chonchol, M.; Cigolini, M.; Targher, G. Association between 25-hydroxyvitamin D deficiency and cardiovascular disease in type 2 diabetic patients with mild kidney dysfunction. Nephrol. Dial. Transplant., 2008, 23(1), 269-274.
104. Targher, G.; Bertolini, L.; Padovani, R.; Zenari, L.; Scala, L.; Cigolini, M.; Arcaro, G. Serum 25 hydroxyvitamin D3 concentrations and carotid artery intima media thickness among type 2 diabetic patients. Clinl. Endocrinol., 2006, 65(5), 593-597.
105. Parker, J.; Hashmi, O.; Dutton, D.; Mavrodaris, A.; Stranges, S.; Kandala, N.B.; Clarke, A.; Franco, O.H. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas, 2010, 65(3), 225-236.
106. Wang, L.; Manson, J.E.; Song, Y.; Sesso, H.D. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann. Intern. Med., 2010, 152(5), 315-323.
107. Trivedi, D.P.; Doll, R.; Khaw, K.T. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ, 2003, 326(7387), 469.
108. Hsia, J.; Heiss, G.; Ren, H.; Allison, M.; Dolan, N.C.; Greenland, P.; Heckbert, S.R.; Johnson, K.C.; Manson, J.E.; Sidney, S.; Trevisan, M. Calcium/vitamin D supplementation and cardiovascular events. Circulation, 2007, 115(7), 846-854.
109. Autier, P.; Gandini, S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch. Intern. Med., 2007, 167(16), 1730-1737.
110. Sun, Q.; Shi, L.; Rimm, E.B.; Giovannucci, E.L.; Hu, F.B.; Manson, J.E.; Rexrode, K.M. Vitamin D intake and risk of cardiovascular disease in US men and women. Am. J. Clin. Nutr., 2011, 94(2), 534-542.
111. Shapses, S.A.; Manson, J.E. Vitamin D and prevention of cardiovascular disease and diabetes: why the evidence falls short. JAMA, 2011, 305(24), 2565-2566.