Is there an association between vitamin D and hypertension?

Recent Patents on Cardiovascular Drug Discovery

Volumn 6, Issue 2, 2011, Pages 140-147

  Cosenso Martin, Luciana N ^a   Vilela Martin, José F ^a  

^a Sao Jose do Rio Preto Medical School   (Brazil)

Author keywords

Bone mineralization; Calcium homeostasis; Cardiovascular disease; Hypertension; Metabolic syndrome; Pathophysiology; Vitamin D; Vitamin D metabolism

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCIUM; CALCIUM CARBONATE; COLECALCIFEROL; ERGOCALCIFEROL; METFORMIN; NATRIURETIC PEPTIDE TYPE C; SUNSCREEN; TROGLITAZONE; VITAMIN D; VITAMIN D RECEPTOR;

BLOOD PRESSURE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; GENE EXPRESSION; HEART; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; VASCULAR ENDOTHELIUM; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

ANIMALS; BLOOD PRESSURE; CALCIUM; HOMEOSTASIS; HUMANS; HYPERTENSION; PATENTS AS TOPIC; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 79959507970     PISSN: 15748901     EISSN: 15748901     Source Type: Journal    
DOI: 10.2174/157489011795933800     Document Type: Review

References (80)

1. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997; 337: 670-76.
2. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: Randomized double blind controlled trial. BMJ 2003; 326: 469-74.
3. Kearney J, Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, et al. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 1996; 143: 907-17.
4. Grant WB. An ecologic study dietary and solar ultraviolet-B links to breast carcinoma mortality rates. Cancer 2002; 94:272-81.
5. Munger KL, Zhang SM, O'Reilly E, Hernán MA, Olek MJ, Willett WC, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60-5.
6. MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80(Suppl 6):1678S-88S.
7. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004; 79: 820-25.
8. Lind L, Hänni A, Lithell H, Hvarfner A, Sörensen OH, Ljunghall S. Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertension 1995; 8: 894-901.
9. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 117: 503-11.
10. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007; 49:1063-69.
11. Forman JP, Curhan GC, Taylor EN. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension 2008; 52: 828-32.
12. Wang L, Manson JE, Buring JE, Lee IM, Sesso HD. Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 2008; 51:1073-9.
13. Almirall J, Vaqueiro M, Baré ML, Anton E. Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly. Nephrol Dial Transplant 2010; 25: 503-9.
14. Margolis KL, Ray RM, Van Horn L, Manson JE, Allison MA, Black HR, et al. Women's Health Initiative Investigators. Effect of calcium and vitamin D supplementation on blood pressure: TheWomen's Health Initiative Randomized Trial. Hypertension 2008; 52: 847-55.
15. Burgaz A, Orsini N, Larsson SC, Wolk A. Blood 25- Hydroxyvitamin D concentration and hypertension: A metaanalysis. J Hypertens 2011; 29: 636-45.
16. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25- Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229-38.
17. Chen S, Ni XP, Humphreys MH, Gardner DG.1,25 Dihydroxyvitamin D amplifies type A natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol 2005;16: 329-39.
18. Vaidya A, Forman JP, Williams JS. Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension. J Hum Hypertens 2010 [Epub ahead of print] doi:10.1038/jhh.2010.110.
19. Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003; 88: 296-307.
20. Holick MF, Tian XQ, Allen M. Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals. Proc Natl Acad Sci USA 1995; 92: 3124-6.
21. MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
22. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006; 84: 18-28.
23. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 1998; 351: 805-6.
24. Thomas KK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, et al. Hypovitaminosis D in medical inpatients. N Engl J Med 1998; 338: 777-83.
25. Thacher TD, Clarke BL. Vitamin D Insufficiency. Mayo Clin Proc 2011; 86: 50-60.
26. Clemens TL, Henderson SL, Adams JS, Holick MF. Increased skin pigment reduces the capacity of skin to synthesis vitamin D3. Lancet 1982; 1(8263):74-6.
27. Matsuoka LY, Ide L, Wortsman J, MacLaughlin J, Holick MF. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab 1987;64:1165-8
28. Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 1985;76: 370-73.
29. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72: 690-3.
30. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006; 81: 353-73.
31. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, et al. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010; 152: 307-14.
32. Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, et al. Vitamin D and Calcium: A Systematic Review of Health Outcomes. Evidence Report No. 183.AHRQ Publication No. 09-E105. Rockville, MD: Agency of Healthcare Research and Quality; 2009. Accessed at www.ahrq.gov/downloads/pub/evidence/pdf/vitadcal.pdf on 4 January 2010.
33. Scragg R, Khaw KT, Murphy S. Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. Eur J Clin Nutr 1995; 49: 640-46.
34. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2006; 83: 754-59.
35. Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabet Med 2009; 26:19-27.
36. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001; 86:1633-37.
37. Major GC, Alarie F, Doré J, Phouttama S, Tremblay A. Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Am J Clin Nutr 2007; 85:54-9.
38. Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med 2008; 25: 320-5.
39. Krause R, Bühring M, Hopfenmüller W, Holick MF, Sharma AM. Ultraviolet B and blood pressure. Lancet 1998; 352(9129): 709-10.
40. Zittermann A, Frisch S, Berthold HK, Göting C, Kuhn J, Kleesiek K, et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 2009; 89: 1321-7.
41. Jorde R, Figenschau Y. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxivitamin D levels. Eur J Nutr 2009; 48: 349-54.
42. Kim MK, Kang MI, Oh KW, Kwon HS, Lee JH, Yoon KH, et al. The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects. Clin Endocrinol 2010; 212: 674-81.
43. Zhao G, Ford ES, Li C, Kris-Etherton PM, Etherton TD, Balluz LS. Independent association of serum concentrations of 25- hydroxyvitamin D and parathyroid hormone with blood pressure among US adults. J Hypertens 2010; 28: 1821-28.
44. Hypponen E, Boucher BJ, Berry DJ, Power C. 25-hyroxyvitamin d, IGF-1,and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008; 57: 298-305.
45. Pasco JA, Henry MJ, Nicholson GC, Brennan SL, Kotowicz MA. Behavioral and physical characteristics associated with vitamin D status in women. Bone 2009; 44: 1085-91.
46. Hintzpeter B, Mensink GB, Thierfelder W, Muller MJ, Scheidt- Nave C. Vitamin D status and health correlates among German adults. Eur J Clin Nutr 2008; 62: 11079-89.
47. Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in general healthcare population. Am J Cardiol 2010; 106: 963-8.
48. Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population.Pediatrics 2009; 124: e371-e379.
49. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factorsand the serum levels of 25-hydroxyvitamin D in the United States: Data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007; 167: 1159-65.
50. Jassal SK, Chonchol M, von Mühlen D, Smits G, Barrett-Connor E. Vitamin D, parathyroid hormone, and cardiovascular mortality in older adults: The Rancho Bernardo study. Am J Med 2010; 123: 1114-20.
51. Holick MF. Vitamin D: The underappreciated D-lightful hormone that isimportant for skeletal and cellular health. Curr Opin Endocrinol Diabetes 2002; 9: 87-98.
52. Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: A negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol 2004; 89-90: 387-92.
53. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: A marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003; 23: 168-75.
54. Correti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the international brachial artery reactivity task force. J Am Coll Cardiol 2002; 39: 257-65.
55. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94: 4023-30.
56. Suzuki Y, Ichiyama T, Ohsaki A, Hasegawa S, Shiraishi M, Furukawa S. Anti-inflammatory effect of 1 alpha, 25- Dihydroxyvitamin D (3) in human coronary artertial endothelial cells: implication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biol 2009; 113: 134-8.
57. Equils O, Naiki Y, Shapiro AM, Michelsen K, Lu D, Adams J, et al. 1, 25-Dihydroxyvitamin D inhibits lipopolysaccharideinduced immune activation in human endothelial cells. Clin Exp Immunol 2006; 143: 58-64.
58. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25- hydroxyvitamin D deficiency is associated with inflammationlinked vascular endothelial dysfunction in middle-aged and older adults. Hypertension 2001; 57:63-9.
59. Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response. FASEB J 1991; 5: 3037-46.
60. Parker TG. Molecular biology of myocardial hypertrophy and failure: Gene expression and trophic signaling. New Horiz 1995; 3: 288-300.
61. Levin ER, Gardner DG, and Samson WK. Natriuretic peptides. N Engl J Med 1998; 339: 321-8.
62. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, et al. Cardiac hypertrophy in vitamin D receptor knockout mice: Role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab 2005; 288: E125-E132.
63. Simpson RU, Hershey SH, Nibbelink KA. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid Biochem Mol Biol 2007; 103: 521-4.
64. Xiang G, Seki T, Schuster MD, Witkowski P, Boyle AJ, See F, et al. J Biol Chem 2005; 280: 39394-402.
65. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E. Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose toleranceand diabetes mellitus. Diabetes Res Clin Pract 1995; 27: 181-8.
66. Inzucchi SE, Maggs DG, Spollett GR, Page SL, Rife FS, Walton V, et al. Efficacy and metaboliceffects of metformin and troglitazone in type II diabetes mellitus. N Engl J Med 1998; 338: 867-72.
67. Inomata S, Kadowaki S, Yamatani T, Fukase M, Fujita T. Effect of 1alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone Miner 1986; 1:187-92.
68. Suga S, Itoh H, Komatsu Y, Ogawa Y, Hama N, Yoshimasa T, et al. Cytokine-induced C-type natriuretic peptide(CNP) secretion from vascular endothelial cells-Evidencefor CNP as a novel autocrine/paracrine regulator fromendothelial cells. Endocrinology 1993; 133: 3038-41.
69. Wu J, Garami M, Cao L, Li Q, Gardner DG. 1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am J Physiol 1995; 268: E1108-E1113.
70. Wu J, Garami M, Cheng T, Gardner DG. 1, 25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. J ClinInvest 1996; 97: 1577-88.
71. Chen S, Costa CH, Nakamura K, Ribeiro RC, Gardner DG. Vitamin D-dependent suppression of human atrial natriuretic peptide gene promoter activity requires heterodimer assembly. J Biol Chem 1999; 274: 11260-66.
72. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J Clin Endocrinol Metab 2011; 96: 53-8.
73. Li, Y. Vitamin D and vitamin D analogs or derivatives as new antihypertensive agents.US20100222307 (2010).
74. Bishop, C.W., Crawford, K.H., Messner, E.J. Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25- hydroxyvitamin D3. US20090311316 (2009).
75. Itescu, S. Method of inhibiting collagen formation by VDUP1 inhibition. US7887796 (2011).
76. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: A prospective study. Arch Intern Med 2008; 168:1174-80.
77. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, et al. Independent association of low serum 25-hydroxyvitamin D an 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch Intern Med 2008;168:1340-49.
78. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 2008;168: 1629-37.
79. Henry HL, Bouillon R, Norman AW, Gallagher JC, Lips P, Heaney RP, et al. 14th Vitamin D Workshop consensus on vitamin D nutritional guidelines. Editorial. J Steroid Biochem Mol Biol 2010; 121: 4-6.
80. Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, et al. TA 2009 Vitamin D and calcium: A systematic review of health outcomes. Evidence Report no. 183 (prepared by the Tufts Evidence-based Practice Center). AHQR Publication no. 9-E015. Rockville, MD: Agency for Healthcare Research and Quality.