Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 11, 2010, Pages 4917-4924

  Adam, Mohamed Abdelgadir ^a   Untch, Brian R ^a   Danko, Melissa E ^a   Stinnett, Sandra ^a   Dixit, Darshana ^a   Koh, James ^a   Marks, Jeffrey R ^a   Olson Jr , John A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ASSESSMENT; COGNITIVE DEFECT; CONSTIPATION; DEPRESSION; DISEASE ASSOCIATION; FATIGUE; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; MAJOR CLINICAL STUDY; MALE; NEPHROLITHIASIS; OBESITY; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID TUMOR; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; VITAMIN D DEFICIENCY; WEAKNESS;

EID: 78049494820     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0666     Document Type: Article

References (39)

1. Ruda JM, Hollenbeak CS, Stack Jr BC 2005 A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg 132:359-372
2. Bilezikian JP, Silverberg SJ 2000 Clinical spectrum of primary hyperparathyroidism. Rev Endocr Metab Disord 1:237-245
3. Grey AB, Evans MC, Stapleton JP, Reid IR 1994 Body weight and bone mineral density in postmenopausal women with primary hyperparathyroidism. Ann Intern Med 121:745-749
4. Bolland MJ, Grey AB, Gamble GD, Reid IR 2005 Association between primary hyperparathyroidism and increased body weight: a meta-analysis. J Clin Endocrinol Metab 90:1525-1530
5. Russell J, Lettieri D, Sherwood LM 1986 Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene. Endocrinology 119:2864-2866
6. Brown AJ, Ritter C, Slatopolsky E, Muralidharan KR, Okamura WH, Reddy GS 1999 1α,25-Dihydroxy-3-epi-vitamin D3, a natural metabolite of 1α,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion. J Cell Biochem 73:106-113 (Pubitemid 29115484)
7. Harinarayan CV, Gupta N, Kochupillai N 1995 Vitamin D status in primary hyperparathyroidism in India. Clin Endocrinol (Oxf) 43:351-358
8. Untch BR, Barfield ME, Dar M, Dixit D, Leight Jr GS, Olson Jr JA 2007 Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. Surgery 142:1022-1026
9. Rao DS, Honasoge M, Divine GW, Phillips ER, Lee MW, Ansari MR, Talpos GB, Parfitt AM 2000 Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. J Clin Endocrinol Metab 85:1054-1058
10. Ozbey N, Erbil Y, Ademoǧlu E, Ozarmagan S, Barbaros U, Bozbora A 2006 Correlations between vitamin D status and biochemical/clinical and pathological parameters in primary hyperparathyroidism. World J Surg 30:321-326 (Pubitemid 43261355)
11. Moosgaard B, Vestergaard P, Heickendorff L, Melsen F, Christiansen P, Mosekilde L 2006 Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study. Eur J Endocrinol 155:237-244
12. Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH 1988 Low circulating vitamin D in obesity. Calcif Tissue Int 43:199-201
13. Need AG, Morris HA, Horowitz M, Nordin C 1993 Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr 58:882-885
14. Bilezikian JP, Potts Jr JT, Fuleihan Gel H, Kleerekoper M, Neer R, Peacock M, Rastad J, Silverberg SJ, Udelsman R, Wells SA 2002 Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century. J Clin Endocrinol Metab 87:5353-5361 (Pubitemid 36034328)
15. Lumb GA, Stanbury SW 1974 Parathyroid function in human vitamin D deficiency and vitamin D deficiency in primary hyperparathyroidism. Am J Med 56:833-839
16. Saab G, Whaley-Connell A, McFarlane SI, Li S, Chen SC, Sowers JR, McCullough PA, Bakris GL 2010 Obesity is associated with increased parathyroid hormone levels independent of glomerular filtration rate in chronic kidney disease. Metabolism 59:385-389
17. Kamycheva E, Sundsfjord J, Jorde R 2004 Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study. Eur J Endocrinol 151:167-172 (Pubitemid 39207010)
18. Lindemann K, Vatten LJ, Ellstrøm-Engh M, Eskild A 2008 Body mass, diabetes and smoking, and endometrial cancer risk: a follow-up study. Br J Cancer 98:1582-1585
19. Bergström A, Pisani P, Tenet V, Wolk A, Adami HO 2001 Overweight as an avoidable cause of cancer in Europe. Int J Cancer 91:421-430
20. Carroll KK 1998 Obesity as a risk factor for certain types of cancer. Lipids 33:1055-1059
21. Freedland SJ, Grubb KA, Yiu SK, Humphreys EB, Nielsen ME, Mangold LA, Isaacs WB, Partin AW 2005 Obesity and risk of biochemical progression following radical prostatectomy at a tertiary care referral center. J Urol 174:919-922
22. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ 2003 Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348:1625-1638
23. Freedland SJ, Bañez LL, Sun LL, Fitzsimons NJ, Moul JW 2009 Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database. Prostate Cancer Prostatic Dis 12:259-263
24. Sandelin K, Skoog L, Humla S, Farnebo LO 1992 Oestrogen, progesterone, and glucocorticoid receptors in normal and neoplastic parathyroid glands. Eur J Surg 158:467-472
25. Wong C, Lai T, Hilly JM, Stewart CE, Farndon JR 2002 Selective estrogen receptor modulators inhibit the effects of insulin-like growth factors in hyperparathyroidism. Surgery 132:998-1006; discussion 1006-1007
26. Boucher A, D'Amour P, Hamel L, Fugère P, Gascon-Barré M, Lepage R, Ste-Marie LG 1989 Estrogen replacement decreases the set point of parathyroid hormone stimulation by calcium in normal postmenopausal women. J Clin Endocrinol Metab 68:831-836
27. Naveh-Many T, Almogi G, Livni N, Silver J 1992 Estrogen receptors and biologic response in rat parathyroid tissue and C cells. J Clin Invest 90:2434-2438 (Pubitemid 23010062)
28. Greenberg C, Kukreja SC, Bowser EN, Hargis GK, Henderson WJ, Williams GA 1987 Parathyroid hormone secretion: effect of estradiol and progesterone. Metabolism 36:151-154
29. Zofková I, Röjdmark S, Kancheva RL 1993 Does estrogen replacement therapy influence parathyroid hormone responsiveness to exogenous hypercalcemia in postmenopausal women? J Endocrinol Invest 16:323-327
30. Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB1997 Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes Relat Metab Disord 21:355-359
31. Tanaka R, Tsushima T, Murakami H, Shizume K, Obara T 1994 Insulin-like growth factor I receptors and insulin-like growth factor-binding proteins in human parathyroid tumors. World J Surg 18:635-641; discussion 641-642
32. Sadler GP, Jones DL, Woodhead JS, Horgan K, Wheeler MH 1996 Effect of growth factor son growth of bovine parathyroid cells inserum-free medium. World J Surg 20:822-828; discussion 828-829
33. Wong CK, Lai T, Holly JM, Wheeler MH, Stewart CE, Farndon JR 2006 Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model. World J Surg 30:333-345
34. Hamoui N, Anthone G, Crookes PF 2004 Calcium metabolism in the morbidly obese. Obes Surg 14:9-12
35. 1991 NIH conference. Diagnosis and management of asymptomatic primary hyperparathyroidism: consensus development conference statement. Ann Intern Med 114:593-597
36. Bergenfelz A, Lindblom P, Lindergård B, Valdemarsson S, Westerdahl J 2003 Preoperative normal level of parathyroid hormone signifies an early and mild form of primary hyperparathyroidism. World J Surg 27:481-485
37. Berger AD, Wu W, Eisner BH, Cooperberg MR, Duh QY, Stoller ML 2009 Patients with primary hyperparathyroidism - why do some form stones? J Urol 181:2141-2145
38. Burney RE, Jones KR, Christy B, Thompson NW 1999 Health status improvement after surgical correction of primary hyperparathyroidism in patients with high and low preoperative calcium levels. Surgery 125:608-614 (Pubitemid 29265002)
39. Repplinger D, Schaefer S, Chen H, Sippel RS 2009 Neurocognitive dysfunction: a predictor of parathyroid hyperplasia. Surgery 146:1138-1143