-
1
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
R. V. Parry, J. M. Chemnitz, K. A. Frauwirth, A. R. Lanfranco, I. Braunstein, S. V. Kobayashi, P. S. Linsley, C. B. Thompson, J. L. Riley, CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 25, 9543-9553 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
Lanfranco, A.R.4
Braunstein, I.5
Kobayashi, S.V.6
Linsley, P.S.7
Thompson, C.B.8
Riley, J.L.9
-
2
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
L. M. Francisco, V. H. Salinas, K. E. Brown, V. K. Vanguri, G. J. Freeman, V. K. Kuchroo, A. H. Sharpe, PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 206, 3015-3029 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
Sharpe, A.H.7
-
3
-
-
77953747963
-
The PD-1 pathway in tolerance and autoimmunity
-
L. M. Francisco, P. T. Sage, A. H. Sharpe, The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236, 219-242 (2010).
-
(2010)
Immunol. Rev.
, vol.236
, pp. 219-242
-
-
Francisco, L.M.1
Sage, P.T.2
Sharpe, A.H.3
-
4
-
-
84863089861
-
Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
-
N. Patsoukis, J. Brown, V. Petkova, F. Liu, L. Li, V. A. Boussiotis, Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci. Signal. 5, ra46 (2012).
-
(2012)
Sci. Signal.
, vol.5
-
-
Patsoukis, N.1
Brown, J.2
Petkova, V.3
Liu, F.4
Li, L.5
Boussiotis, V.A.6
-
5
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
-
(1995)
J. Immunol.
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
6
-
-
0029788211
-
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
-
M. Asano, M. Toda, N. Sakaguchi, S. Sakaguchi, Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184, 387-396 (1996).
-
(1996)
J. Exp. Med.
, vol.184
, pp. 387-396
-
-
Asano, M.1
Toda, M.2
Sakaguchi, N.3
Sakaguchi, S.4
-
7
-
-
0031821875
-
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
A. M. Thornton, E. M. Shevach, CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287-296 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
8
-
-
74049164847
-
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
-
K. Wing, S. Sakaguchi, Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 11, 7-13 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 7-13
-
-
Wing, K.1
Sakaguchi, S.2
-
9
-
-
77950349016
-
Th17 and regulatory T cells in mediating and restraining inflammation
-
D. R. Littman, A. Y. Rudensky, Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140, 845-858 (2010).
-
(2010)
Cell
, vol.140
, pp. 845-858
-
-
Littman, D.R.1
Rudensky, A.Y.2
-
10
-
-
79251500661
-
Phenotypical and functional specialization of FOXP3+ regulatory T cells
-
D. J. Campbell, M. A. Koch, Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol. 11, 119-130 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 119-130
-
-
Campbell, D.J.1
Koch, M.A.2
-
11
-
-
67649170980
-
Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes
-
M. Feuerer, J. A. Hill, D. Mathis, C. Benoist, Foxp3+ regulatory T cells: Differentiation, specification, subphenotypes. Nat. Immunol. 10, 689-695 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 689-695
-
-
Feuerer, M.1
Hill, J.A.2
Mathis, D.3
Benoist, C.4
-
12
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
S. Sakaguchi, M. Miyara, C. M. Costantino, D. A. Hafler, FOXP3+ regulatory T cells in the human immune system. Nat. Rev. Immunol. 10, 490-500 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
Hafler, D.A.4
-
13
-
-
77649220954
-
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
-
J. J. O'Shea, W. E. Paul, Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327, 1098-1102 (2010).
-
(2010)
Science
, vol.327
, pp. 1098-1102
-
-
O'Shea, J.J.1
Paul, W.E.2
-
14
-
-
82755182684
-
Regulatory T cell therapy for the induction of clinical organ transplantation tolerance
-
H. Fan, P. Cao, D. S. Game, F. Dazzi, Z. Liu, S. Jiang, Regulatory T cell therapy for the induction of clinical organ transplantation tolerance. Semin. Immunol. 23, 453-461 (2011).
-
(2011)
Semin. Immunol.
, vol.23
, pp. 453-461
-
-
Fan, H.1
Cao, P.2
Game, D.S.3
Dazzi, F.4
Liu, Z.5
Jiang, S.6
-
15
-
-
70249122695
-
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells
-
P. Trzonkowski, M. Bieniaszewska, J. Ju?ci?ska, A. Dobyszuk, A. Krzystyniak, N. Marek, J. My?liwska, A. Hellmann, First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin. Immunol. 133, 22-26 (2009).
-
(2009)
Clin. Immunol.
, vol.133
, pp. 22-26
-
-
Trzonkowski, P.1
Bieniaszewska, M.2
Juciska, J.3
Dobyszuk, A.4
Krzystyniak, A.5
Marek, N.6
Myliwska, J.7
Hellmann, A.8
-
16
-
-
78751696183
-
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
-
C. G. Brunstein, J. S. Miller, Q. Cao, D. H. McKenna, K. L. Hippen, J. Curtsinger, T. Defor, B. L. Levine, C. H. June, P. Rubinstein, P. B. McGlave, B. R. Blazar, J. E. Wagner, Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics. Blood 117, 1061-1070 (2011).
-
(2011)
Blood
, vol.117
, pp. 1061-1070
-
-
Brunstein, C.G.1
Miller, J.S.2
Cao, Q.3
McKenna, D.H.4
Hippen, K.L.5
Curtsinger, J.6
Defor, T.7
Levine, B.L.8
June, C.H.9
Rubinstein, P.10
McGlave, P.B.11
Blazar, B.R.12
Wagner, J.E.13
-
17
-
-
79953809817
-
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
-
M. Di Ianni, F. Falzetti, A. Carotti, A. Terenzi, F. Castellino, E. Bonifacio, B. Del Papa, T. Zei, R. I. Ostini, D. Cecchini, T. Aloisi, K. Perruccio, L. Ruggeri, C. Balucani, A. Pierini, P. Sportoletti, C. Aristei, B. Falini, Y. Reisner, A. Velardi, F. Aversa, M. F. Martelli, Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 117, 3921-3928 (2011).
-
(2011)
Blood
, vol.117
, pp. 3921-3928
-
-
Di Ianni, M.1
Falzetti, F.2
Carotti, A.3
Terenzi, A.4
Castellino, F.5
Bonifacio, E.6
Del Papa, B.7
Zei, T.8
Ostini, R.I.9
Cecchini, D.10
Aloisi, T.11
Perruccio, K.12
Ruggeri, L.13
Balucani, C.14
Pierini, A.15
Sportoletti, P.16
Aristei, C.17
Falini, B.18
Reisner, Y.19
Velardi, A.20
Aversa, F.21
Martelli, M.F.22
more..
-
18
-
-
79956260076
-
Regulatory T cells: Customizing for the clinic
-
X. Wang, L. Lu, S. Jiang, Regulatory T cells: Customizing for the clinic. Sci. Transl. Med. 3, 83ps19 (2011).
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Wang, X.1
Lu, L.2
Jiang, S.3
-
19
-
-
65449141433
-
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
-
P. Hoffmann, T. J. Boeld, R. Eder, J. Huehn, S. Floess, G. Wieczorek, S. Olek, W. Dietmaier, R. Andreesen, M. Edinger, Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur. J. Immunol. 39, 1088-1097 (2009).
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 1088-1097
-
-
Hoffmann, P.1
Boeld, T.J.2
Eder, R.3
Huehn, J.4
Floess, S.5
Wieczorek, G.6
Olek, S.7
Dietmaier, W.8
Andreesen, R.9
Edinger, M.10
-
20
-
-
70949097273
-
Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice
-
Q. Zheng, Y. Xu, Y. Liu, B. Zhang, X. Li, F. Guo, Y. Zhao, Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice. J. Mol. Med. (Berlin) 87, 1191-1205 (2009).
-
(2009)
J. Mol. Med. (Berlin)
, vol.87
, pp. 1191-1205
-
-
Zheng, Q.1
Xu, Y.2
Liu, Y.3
Zhang, B.4
Li, X.5
Guo, F.6
Zhao, Y.7
-
21
-
-
80052277906
-
reg balance by hypoxia-inducible factor 1
-
reg balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
Luo, W.11
Zeller, K.12
Shimoda, L.13
Topalian, S.L.14
Semenza, G.L.15
Dang, C.V.16
Pardoll, D.M.17
Pan, F.18
-
22
-
-
79960369458
-
regcells
-
regcells. J. Exp. Med. 208, 1367-1376 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
Chi, H.7
-
23
-
-
34248379172
-
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
-
B. Li, A. Samanta, X. Song, K. T. Iacono, K. Bembas, R. Tao, S. Basu, J. L. Riley, W. W. Hancock, Y. Shen, S. J. Saouaf, M. I. Greene, FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl. Acad. Sci. U.S.A. 104, 4571-4576 (2007).
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 4571-4576
-
-
Li, B.1
Samanta, A.2
Song, X.3
Iacono, K.T.4
Bembas, K.5
Tao, R.6
Basu, S.7
Riley, J.L.8
Hancock, W.W.9
Shen, Y.10
Saouaf, S.J.11
Greene, M.I.12
-
24
-
-
77649225958
-
reg functionality by acetylation-mediated Foxp3 protein stabilization
-
reg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 115, 965-974 (2010).
-
(2010)
Blood
, vol.115
, pp. 965-974
-
-
Van Loosdregt, J.1
Vercoulen, Y.2
Guichelaar, T.3
Gent, Y.Y.4
Beekman, J.M.5
Van Beekum, O.6
Brenkman, A.B.7
Hijnen, D.J.8
Mutis, T.9
Kalkhoven, E.10
Prakken, B.J.11
Coffer, P.J.12
-
25
-
-
84863378890
-
Histone/protein deacetylases and T-cell immune responses
-
T. Akimova, U. H. Beier, Y. Liu, L. Wang, W. W. Hancock, Histone/protein deacetylases and T-cell immune responses. Blood 119, 2443-2451 (2012).
-
(2012)
Blood
, vol.119
, pp. 2443-2451
-
-
Akimova, T.1
Beier, U.H.2
Liu, Y.3
Wang, L.4
Hancock, W.W.5
-
26
-
-
77955277730
-
regs
-
regs. Clin. Immunol. 136, 348-363 (2010).
-
(2010)
Clin. Immunol.
, vol.136
, pp. 348-363
-
-
Akimova, T.1
Ge, G.2
Golovina, T.3
Mikheeva, T.4
Wang, L.5
Riley, J.L.6
Hancock, W.W.7
-
27
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
R. Tao, E. F. de Zoeten, E. Ozkaynak, C. Chen, L. Wang, P. M. Porrett, B. Li, L. A. Turka, E. N. Olson, M. I. Greene, A. D. Wells, W. W. Hancock, Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
De Zoeten, E.F.2
Ozkaynak, E.3
Chen, C.4
Wang, L.5
Porrett, P.M.6
Li, B.7
Turka, L.A.8
Olson, E.N.9
Greene, M.I.10
Wells, A.D.11
Hancock, W.W.12
-
28
-
-
84862881397
-
Histone deacetylases 6 and 9 and sirtuin-1 control foxp3+ regulatory T cell function through shared and isoform-specific mechanisms
-
U. H. Beier, L. Wang, R. Han, T. Akimova, Y. Liu, W. W. Hancock, Histone deacetylases 6 and 9 and sirtuin-1 control foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci. Signal. 5, ra45 (2012).
-
(2012)
Sci. Signal.
, vol.5
-
-
Beier, U.H.1
Wang, L.2
Han, R.3
Akimova, T.4
Liu, Y.5
Hancock, W.W.6
|