Genome-based approaches to vaccine development

Journal of Molecular Medicine

Volumn 88, Issue 2, 2010, Pages 143-147

  Mora, Marirosa ^a   Telford, John L ^a  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

Antigens prioritization; Reverse vaccinology

Indexed keywords

EPITOPE; FIBRONECTIN BINDING PROTEIN; LIPOPROTEIN;

ALGORITHM; ANTIGEN DETECTION; B LYMPHOCYTE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM PILUS; BIOINFORMATICS; CORYNEBACTERIUM DIPHTHERIAE; DATA MINING; GENE MAPPING; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC VARIABILITY; IMMUNIZATION; IMMUNOGENICITY; IMMUNOREACTIVITY; MASS SPECTROMETRY; METHODOLOGY; NEISSERIA MENINGITIDIS; NONHUMAN; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PURIFICATION; PROTEOMICS; REVERSE VACCINOLOGY; REVIEW; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; T LYMPHOCYTE;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; COMPUTATIONAL BIOLOGY; DRUG DESIGN; GENOME, BACTERIAL; GENOMICS; HUMANS;

EID: 77951206500     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0574-9     Document Type: Review

References (29)

1. RD Fleischmann MD Adams O White RA Clayton EF Kirkness AR Kerlavage CJ Bult JF Tomb BA Dougherty JM Merrick, et al. 1995 Whole-genome random sequencing and assembly of Haemophilus influenzae Rd Science 269 496 512 10.1126/science.7542800 1:CAS:528:DyaK2MXntF2ksLc%3D 7542800
2. R Rappuoli 2000 Reverse vaccinology Curr Opin Microbiol 3 445 450 10.1016/S1369-5274(00)00119-3 1:CAS:528:DC%2BD3cXotVOit70%3D 11050440
3. R Rappuoli 2001 Reverse vaccinology, a genome-based approach to vaccine development Vaccine 19 2688 2691 10.1016/S0264-410X(00)00554-5 1:CAS:528:DC%2BD3MXitVOit78%3D 11257410 (Pubitemid 32234290)
4. I Goldschneider EC Gotschlich MS Artenstein 1969 Human immunity to the meningococcus. I. The role of humoral antibodies J Exp Med 129 1307 1326 10.1084/jem.129.6.1307 1:STN:280:DyaF1M7psV2gsQ%3D%3D 4977280
5. SC Ross PJ Rosenthal HM Berberich P Densen 1987 Killing of Neisseria meningitidis by human neutrophils: implications for normal and complement-deficient individuals J Infect Dis 155 1266 1275 1:STN:280: DyaL2s7ps1Grsg%3D%3D 3106511
6. M Pizza V Scarlato V Masignani MM Giuliani B Arico M Comanducci GT Jennings L Baldi E Bartolini B Capecchi CL Galeotti E Luzzi R Manetti E Marchetti M Mora S Nuti G Ratti L Santini S Savino M Scarselli E Storni P Zuo M Broeker E Hundt B Knapp E Blair T Mason H Tettelin DW Hood AC Jeffries NJ Saunders DM Granoff JC Venter ER Moxon G Grandi R Rappuoli 2000 Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing Science 287 1816 1820 10.1126/science.287.5459.1816 1:CAS:528:DC%2BD3cXhvVWksbk%3D 10710308 (Pubitemid 30143965)
7. DN Chakravarti MJ Fiske LD Fletcher RJ Zagursky 2000 Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates Vaccine 19 601 612 10.1016/S0264-410X(00)00256-5 1:CAS:528:DC%2BD3cXot12lsL0%3D 11090710
8. BC Ross L Czajkowski D Hocking M Margetts E Webb L Rothel M Patterson C Agius S Camuglia E Reynolds T Littlejohn B Gaeta A Ng ES Kuczek JS Mattick D Gearing IG Barr 2001 Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis Vaccine 19 4135 4142 10.1016/S0264- 410X(01)00173-6 1:CAS:528:DC%2BD3MXlt1Shs74%3D 11457538 (Pubitemid 32703633)
9. TM Wizemann JH Heinrichs JE Adamou AL Erwin C Kunsch GH Choi SC Barash CA Rosen HR Masure E Tuomanen A Gayle YA Brewah W Walsh P Barren R Lathigra M Hanson S Langermann S Johnson S Koenig 2001 Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection Infect Immun 69 1593 1598 10.1128/IAI.69.3.1593-1598.2001 1:CAS:528:DC%2BD3MXitFGrtbg%3D 11179332 (Pubitemid 32187614)
10. N Ariel A Zvi H Grosfeld O Gat Y Inbar B Velan S Cohen A Shafferman 2002 Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening Infect Immun 70 6817 6827 10.1128/IAI.70.12.6817-6827.2002 1:CAS:528:DC%2BD38XptVyiurc%3D 12438358 (Pubitemid 35387914)
11. S Montigiani F Falugi M Scarselli O Finco R Petracca G Galli M Mariani R Manetti M Agnusdei R Cevenini M Donati R Nogarotto N Norais I Garaguso S Nuti G Saletti D Rosa G Ratti G Grandi 2002 Genomic approach for analysis of surface proteins in Chlamydia pneumoniae Infect Immun 70 368 379 10.1128/IAI.70.1.368- 379.2002 1:CAS:528:DC%2BD3MXptlKhtLc%3D 11748203 (Pubitemid 34028637)
12. K Al-Hasani J Boyce VP McCarl S Bottomley I Wilkie B Adler 2007 Identification of novel immunogens in Pasteurella multocida Microb Cell Fact 6 3 10.1186/1475-2859-6-3 17233917 (Pubitemid 46210989)
13. S Bambini R Rappuoli 2009 The use of genomics in microbial vaccine development Drug Discov Today 14 252 260 10.1016/j.drudis.2008.12.007 1:CAS:528:DC%2BD1MXjt1Shtrg%3D 19150507
14. H Tettelin V Masignani MJ Cieslewicz C Donati D Medini NL Ward SV Angiuoli J Crabtree AL Jones AS Durkin RT Deboy TM Davidsen M Mora M Scarselli I Margarit y Ros JD Peterson CR Hauser JP Sundaram WC Nelson R Madupu LM Brinkac RJ Dodson MJ Rosovitz SA Sullivan SC Daugherty DH Haft J Selengut ML Gwinn L Zhou N Zafar H Khouri D Radune G Dimitrov K Watkins KJ O'Connor S Smith TR Utterback O White CE Rubens G Grandi LC Madoff DL Kasper JL Telford MR Wessels R Rappuoli CM Fraser 2005 Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome" Proc Natl Acad Sci U S A 102 13950 13955 10.1073/pnas.0506758102 1:CAS:528:DC%2BD2MXhtVOqsbjL 16172379 (Pubitemid 41377684)
15. D Maione I Margarit CD Rinaudo V Masignani M Mora M Scarselli H Tettelin C Brettoni ET Iacobini R Rosini N D'Agostino L Miorin S Buccato M Mariani G Galli R Nogarotto V Nardi Dei F Vegni C Fraser G Mancuso G Teti LC Madoff LC Paoletti R Rappuoli DL Kasper JL Telford G Grandi 2005 Identification of a universal Group B streptococcus vaccine by multiple genome screen Science 309 148 150 10.1126/science.1109869 1:CAS:528:DC%2BD2MXlsF2ht7o%3D 15994562 (Pubitemid 40934997)
16. P Lauer CD Rinaudo M Soriani I Margarit D Maione R Rosini AR Taddei M Mora R Rappuoli G Grandi JL Telford 2005 Genome analysis reveals pili in Group B Streptococcus Science 309 105 10.1126/science.1111563 1:CAS:528: DC%2BD2MXlvVKmtr0%3D 15994549 (Pubitemid 40934983)
17. M Mora G Bensi S Capo F Falugi C Zingaretti AG Manetti T Maggi AR Taddei G Grandi JL Telford 2005 Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens Proc Natl Acad Sci U S A 102 15641 15646 10.1073/pnas.0507808102 1:CAS:528:DC%2BD2MXht1ShtrbE 16223875 (Pubitemid 41528109)
18. DE Bessen A Kalia 2002 Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes Infect Immun 70 1159 1167 10.1128/IAI.70.3.1159-1167.2002 1:CAS:528:DC%2BD38XhsFSlsrw%3D 11854196 (Pubitemid 34163387)
19. F Falugi C Zingaretti V Pinto M Mariani L Amodeo AG Manetti S Capo JM Musser G Orefici I Margarit JL Telford G Grandi M Mora 2008 Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes J Infect Dis 198 1834 1841 10.1086/593176 1:CAS:528:DC%2BD1MXhtFSlur8%3D 18928376
20. MA Barocchi J Ries X Zogaj C Hemsley B Albiger A Kanth S Dahlberg J Fernebro M Moschioni V Masignani K Hultenby AR Taddei K Beiter F Wartha A von Euler A Covacci DW Holden S Normark R Rappuoli B Henriques-Normark 2006 A pneumococcal pilus influences virulence and host inflammatory responses Proc Natl Acad Sci U S A 103 2857 2862 10.1073/pnas.0511017103 1:CAS:528: DC%2BD28XksF2rtbw%3D 16481624
21. C Gianfaldoni S Censini M Hilleringmann M Moschioni C Facciotti W Pansegrau V Masignani A Covacci R Rappuoli MA Barocchi P Ruggiero 2007 Streptococcus pneumoniae pilus subunits protect mice against lethal challenge Infect Immun 75 1059 1062 10.1128/IAI.01400-06 1:CAS:528:DC%2BD2sXhs1ahtro%3D 17145945 (Pubitemid 46203474)
22. F Bagnoli M Moschioni C Donati V Dimitrovska I Ferlenghi C Facciotti A Muzzi F Giusti C Emolo A Sinisi M Hilleringmann W Pansegrau S Censini R Rappuoli A Covacci V Masignani MA Barocchi 2008 A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells J Bacteriol 190 5480 5492 10.1128/JB.00384-08 1:CAS:528: DC%2BD1cXpt1WiurY%3D 18515415
23. M Moschioni C Donati A Muzzi V Masignani S Censini WP Hanage CJ Bishop JN Reis S Normark B Henriques-Normark A Covacci R Rappuoli MA Barocchi 2008 Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related J Infect Dis 197 888 896 10.1086/528375 1:CAS:528:DC%2BD1cXksFKgsrg%3D 18269316 (Pubitemid 351417013)
24. M Bombaci R Grifantini M Mora V Reguzzi R Petracca E Meoni S Balloni C Zingaretti F Falugi AG Manetti I Margarit JM Musser F Cardona G Orefici G Grandi G Bensi 2009 Protein array profiling of tic patient sera reveals a broad range and enhanced immune response against Group A Streptococcus antigens PLoS ONE 4 e6332 10.1371/journal.pone.0006332 19623252
25. A Meinke T Henics M Hanner DB Minh E Nagy 2005 Antigenome technology: a novel approach for the selection of bacterial vaccine candidate antigens Vaccine 23 2035 2041 10.1016/j.vaccine.2005.01.005 1:CAS:528:DC%2BD2MXitVCgsL8%3D 15755567 (Pubitemid 40341423)
26. MJ Rodriguez-Ortega N Norais G Bensi S Liberatori S Capo M Mora M Scarselli F Doro G Ferrari I Garaguso T Maggi A Neumann A Covre JL Telford G Grandi 2006 Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome Nat Biotechnol 24 191 197 10.1038/nbt1179 1:CAS:528:DC%2BD28XhtFGqsrY%3D 16415855 (Pubitemid 43221703)
27. EK Jagusztyn-Krynicka M Dadlez A Grabowska P Roszczenko 2009 Proteomic technology in the design of new effective antibacterial vaccines Expert Rev Proteomics 6 315 330 10.1586/epr.09.47 1:CAS:528:DC%2BD1MXms12nu7k%3D 19489702
28. AS De Groot 2006 Immunomics: discovering new targets for vaccines and therapeutics Drug Discov Today 11 203 209 10.1016/S1359-6446(05)03720-7 16580597
29. M Stalhammar-Carlemalm J Waldemarsson E Johnsson T Areschoug G Lindahl 2007 Nonimmunodominant regions are effective as building blocks in a streptococcal fusion protein vaccine Cell Host Microbe 2 427 434 10.1016/j.chom.2007.10.003 18078694 (Pubitemid 350215324)