Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy

Journal of Rheumatology

Volumn 39, Issue 8, 2012, Pages 1524-1532

  Oliveira, Renê Donizeti Ribeiro ^a   Fontana, Vanessa ^a   Junta, Cristina Moraes ^a   Marques, Márcia Maria Chiquitelli ^a   Macedo, Cláudia ^a   Rassi, Diane Meyre ^a   Passos, Geraldo Aleixo ^a   Donadi, Eduardo Antonio ^a   Louzada, Paulo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Methotrexate; Microarray analysis; Monoclonal antibodies; Rheumatoid arthritis; Treatment outcome

Indexed keywords

BCL2 RELATED PROTEIN A1; CASPASE 8; CAVEOLIN 1; CD83 ANTIGEN; INFLIXIMAB; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; METHOTREXATE; PREDNISONE; SERINE PROTEINASE OMI; TUMOR NECROSIS FACTOR INHIBITOR;

ADULT; AGED; ARTICLE; BCL2A1 GENE; BTG2 GENE; CASP8AP2 GENE; CAV1 GENE; CCL4 GENE; CLINICAL ARTICLE; DISEASE ACTIVITY; DISEASE CLASSIFICATION; FEMALE; GENE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE REPRESSION; GENETIC ANALYSIS; HTRA2 GENE; HUMAN; MALE; MICROARRAY ANALYSIS; MXD1 GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PRKCD GENE; RHEUMATOID ARTHRITIS; TNIP1 GENE; TREATMENT RESPONSE;

EID: 84864539414     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.120092     Document Type: Article

References (43)

1. Klareskog L, Catrina AI, Paget S. Rheumatoid arthritis. Lancet 2009;373:659-72.
2. Oliveira RD, Junta CM, Oliveira FR, Silva LM, Donadi EA, Louzada-Junior P. Share epitope, citrullinated cyclic peptide antibodies and smoking in Brazilian rheumatoid arthritis patients. Clin Rev Allergy Immunol 2008;34:32-5.
3. Balsa A, del Amo J, Blanco F, Caliz R, Silva L, Sanmarti R, et al. Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms. Rheumatology 2010;49:458-66.
4. Kremer JM, Lee JK. The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum 1986;29:822-31. (Pubitemid 16072879)
5. Grigor C, Capell H, Stirling A, McMahon AD, Lock P, Vallance R, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): A single-blind randomized controlled trial. Lancet 2004;364:263-9. (Pubitemid 38942816)
6. Brinker RR, Ranganathan P. Methotrexate pharmacogenetics in rheumatoid arthritis. Clin Exp Rheumatol 2010;28 Suppl 61:33-9.
7. Wessels JA, van der Kooij SM, le Cessie S, Kievit W, Barerra P, Allaart CF, et al. A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum 2007;56:1765-75. (Pubitemid 47110376)
8. Galloway JB, Hyrich KL, Mercer LK, Dixon WG, Fu B, Ustianowski AP, et al. Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: Updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly. Rheumatology 2011;50:124-31.
9. Hyrich KL, Watson KD, Silman AJ, Symmons DP and The BSR Biologics Register. Predictors of response to anti-TNF-a therapy among patients with rheumatoid arthritis: Results from the British Society for Rheumatology Biologics Register. Rheumatology 2006;45:1558-65. (Pubitemid 44817065)
10. Kooloos WM, Huizinga TW, Guchelaar HJ, Wessels JA. Pharmacogenetics in treatment of rheumatoid arthritis. Curr Pharm Des 2010;16:164-75.
11. Verweij CL. Transcript profiling towards personalised medicine in rheumatoid arthritis. Neth J Med 2009;67:364-71.
12. Junta CM, Sandrin-Garcia P, Fachin-Saltoratto AL, Mello SS, Oliveira RD, Rassi DM, et al. Differential gene expression of peripheral blood mononuclear cells from rheumatoid arthritis patients may discriminate immunogenetic, pathogenic and treatment features. Immunology 2009;127:365-72.
13. Koczan D, Drynda S, Hecker M, Drynda A, Guthke R, Kekow J, et al. Molecular discrimination of responders and non-responders to anti-TNF-alpha therapy in rheumatoid arthritis by etanercept. Arthritis Res Ther 2008;10:R50.
14. Lequerré T, Gauthier-Jauneau AC, Bansard C, Derambure C, Hiron M, Vittecoq O, et al. Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis. Arthritis Res Ther 2006;8:R105.
15. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
16. van Gestel AM, Haagsma CJ, van Riel PL. Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis Rheum 1998;41:1845-50.
17. Hegde P, Qi K, Abernathy C, Gay C, Dharap S, Gaspard R, et al. Concise guide to cDNA microarray analysis. Biotechniques 2000;29:548-62.
18. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, et al. TM4: A free, open-source system for microarray data management and analysis. Biotechniques 2003;34:374-8. (Pubitemid 36184095)
19. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001;98:5116-21. (Pubitemid 32397092)
20. van Baarsen LG, Bos CL, van der Pouw Kraan TC, Verweij CL. Transcription profiling of rheumatic diseases. Arthritis Res Ther 2009;11:207-19.
21. Yamagata T, Benoist C, Mathis DA. Shared gene-expression signature in innate-like lymphocytes. Immunol Rev 2006;210:52-66.
22. Toonen EJ, Barrera P, Radstake TR, van Riel PL, Scheffer H, Franke B, et al. Gene expression profiling in rheumatoid arthritis: Current concepts and future directions. Ann Rheum Dis 2008;67:1663-9.
23. Gu J, Marker-Hermann E, Baeten D, Tsai WC, Gladman D, Xiong M, et al. A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients. Rheumatology 2002;41:759-66. (Pubitemid 34822958)
24. Marotte H, Pallot-Prades B, Grange L, Tebib J, Gaudin P, Alexandre C, et al. The shared epitope is a marker of severity associated with selection for, but not with response to, infliximab in a large rheumatoid arthritis population. Ann Rheum Dis 2006;65:342-7. (Pubitemid 43268223)
25. Silva GL, Junta CM, Sakamoto-Hojo ET, Donadi EA, Louzada-Junior P, Passos GA. Genetic susceptibility loci in rheumatoid arthritis establish transcriptional regulatory networks with other genes. Ann NY Acad Sci 2009;1173:521-37.
26. De Antonio SR, Blotta HM, Mamoni RL, Louzada P, Bertolo MB, Foss NT, et al. Effects of dexamethasone on lymphocyte proliferation and cytokine production in rheumatoid arthritis. J Rheumatol 2002;29:46-51. (Pubitemid 34041857)
27. Cutolo M, Villaggio B, Pizzorni C, Paolino S, Moretti S, Gallo F, et al. Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment. Ann NY Acad Sci 2010;1193:15-21.
28. Häupl T, Yahyawi M, Lübke C, Ringe J, Rohrlach T, Burmester GR, et al. Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen 2007;12:328-40. (Pubitemid 46514675)
29. Lories RJ, Derese I, De Bari C, Luyten FP. In vitro growth rate of fibroblast-like synovial cells is reduced by methotrexate treatment. Ann Rheum Dis 2003;62:568-71. (Pubitemid 36606293)
30. Herman S, Zurgil N, Deutsch M. Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines. Inflamm Res 2005;54:273-80. (Pubitemid 41185488)
31. Lindberg J, Klint E, Catrina A, Nilsson P, Klareskog L, Ulfgren A, et al. Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients. Arthritis Res Ther 2006;8:R179.
32. Johnston A, Gudjonsson JE, Sigmundsdottir H, Ludviksson BR, Valdimarsson H. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 2005;114:154-63. (Pubitemid 40082381)
33. Louzada-Júnior L, Freitas MV, Oliveira RD, Deghaide NH, Conde RA, Bértolo MB, et al. A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrullinated peptide antibodies. Braz J Med Biol Res 2008;41:493-9.
34. Kazkaz L, Marotte H, Hamwi M, Angélique Cazalis M, Roy P, Mougin B, et al. Rheumatoid arthritis and genetic markers in Syrian and French populations: Different effect of the shared epitope. Ann Rheum Dis 2007;66:195-201. (Pubitemid 46226054)
35. Martinez A, Salido M, Bonilla G, Pascual-Salcedo D, Fernandez-Arquero M, de Miguel S, et al. Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients. Arthritis Rheum 2004;50:1077-82. (Pubitemid 38480817)
36. Pinto JA, Rego I, Rodriguez-Gomez M, Cañete JD, Fernandez-López C, Freire M, et al. Polymorphisms in genes encoding tumor necrosis factor-alpha and HLA-DRB1 are not associated with response to infliximab in patients with rheumatoid arthritis. J Rheumatol 2008;35:177-8.
37. Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ, et al. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 2009;16:1030-9.
38. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429-42. (Pubitemid 46834849)
39. Zheng W, Li R, Pan H, He D, Xu R, Guo TB, et al. Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1β through the NF-βB and MAPK pathways in rheumatoid arthritis. Arthritis Rheum 2009;60:1957-65.
40. McKinsey TA, Chu Z, Tedder TF, Ballard DW. Transcription factor NF-kappa B regulates inducible CD83 gene expression in activated T lymphocytes. Mol Immunol 2000;37:783-8.
41. Wolenski M, Cramer SO, Ehrlich S, Steeg C, Fleischer B, von Bonin A. Enhanced activation of CD83-positive T cells. Scand J Immunol 2003;58:306-11. (Pubitemid 37100366)
42. Juliá A, Erra A, Palacio C, Tomas C, Sans X, Barceló P, et al. An eight-gene blood expression profile predicts the response to infliximab in rheumatoid arthritis. Plos One 2009;4:e7556.
43. Makrygiannakis D, Catrina AI. Apoptosis as a mechanism of action of tumor necrosis factor antagonists in rheumatoid arthritis. J Rheumatol 2012;39:679-85.