The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

Clinical Immunology

Volumn 114, Issue 2, 2005, Pages 154-163

  Johnston, Andrew ^a   Gudjonsson, Johann Eli ^a   Sigmundsdottir, Hekla ^a   Runar Ludviksson, Björn ^a   Valdimarsson, Helgi ^a  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Adenosine; Apoptosis; CLA; ICAM 1; Methotrexate; Psoriasis

Indexed keywords

ADENOSINE; ANTIGEN; ANTIINFLAMMATORY AGENT; CELL ADHESION MOLECULE; CUTANEOUS LYMPHOCYTE ASSOCIATED ANTIGEN; FOLIC ACID; INTERCELLULAR ADHESION MOLECULE 1; METHOTREXATE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; LYMPHOCYTE FUNCTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

ADENOSINE; ANTI-INFLAMMATORY AGENTS; ANTIGENS, BACTERIAL; ANTIGENS, NEOPLASM; APOPTOSIS; CELL ADHESION MOLECULES; FLOW CYTOMETRY; FUCOSYLTRANSFERASES; HUMANS; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; LEUCOVORIN; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; METHOTREXATE; RECEPTORS, INTERLEUKIN-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; STREPTOCOCCUS PYOGENES; T-LYMPHOCYTES;

EID: 11444251484     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2004.09.001     Document Type: Article

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