A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 6, 2008, Pages 493-499

  Louzada Junior P ^a   Freitas, M V C ^a   Oliveira, R D R ^a   Deghaide, N H S ^a   Conde, R A ^b   Bertolo, M B ^b   Donadi, E A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Anti cyclic citrullinated peptide; Brazilians; HLA; Shared epitope; Susceptibility to rheumatoid arthritis

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; DNA; EPITOPE; HLA DR ANTIGEN;

ADULT; AGED; ALLELE; ARTICLE; BRAZIL; CAUCASIAN; CONTROLLED STUDY; DISEASE DURATION; DNA HYBRIDIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC COMPLEMENTATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; IMMUNITY; MAJOR CLINICAL STUDY; MALE; NEGRO; OLIGONUCLEOTIDE PROBE; PATHOGENESIS; POPULATION GENETICS; RACE DIFFERENCE; RHEUMATOID ARTHRITIS; SEQUENCE ANALYSIS;

ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BRAZIL; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 54749155927     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008005000021     Document Type: Article

References (40)

1. Stastny P. Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest 1976; 57: 1148-1157.
2. Nepom GT, Seyfried CE, Holbeck SL, Wilske KR, Nepom BS. Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis. Lancet 1986; 2: 1002-1005.
3. Wordsworth BP, Lanchbury JS, Sakkas LI, Welsh KI, Panayi GS, Bell JI. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci U S A 1989; 86: 10049-10053.
4. Ohta N, Nishimura YK, Tanimoto K, Horiuchi Y, Abe C, Shiokawa Y, et al. Association between HLA and Japanese patients with rheumatoid arthritis. Hum Immunol 1982; 5: 123-132.
5. Nichol FE, Woodrow JC. HLA DR antigens in Indian patients with rheumatoid arthritis. Lancet 1981; 1: 220-221.
6. Schiff B, Mizrachi Y, Orgad S, Yaron M, Gazit E. Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis. Ann Rheum Dis 1982; 41: 403-404.
7. Sanchez B, Moreno I, Magarino R, Garzon M, Gonzalez MF, Garcia A, et al. HLA-DRw10 confers the highest susceptibility to rheumatoid arthritis in a Spanish population. Tissue Antigens 1990; 36: 174-176.
8. Pile KD, Tikly M, Bell JI, Wordsworth BP. HLA-DR antigens and rheumatoid arthritis in black South Africans: a study of ethnic groups. Tissue Antigens 1992; 39: 138-140.
9. Willkens RF, Nepom GT, Marks CR, Nettles JW, Nepom BS. Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis. Arthritis Rheum 1991; 34: 43-47.
10. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-1213.
11. de Vries N, Tijssen H, van Riel PL, van de Putte LB. Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1 molecule. Arthritis Rheum 2002; 46: 921-928.
12. Seidl C, Korbitzer J, Badenhoop K, Seifried E, Hoelzer D, Zanelli E, et al. Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients. Hum Immunol 2001; 62: 523-529.
13. van der Helm-van Mil AH, Huizinga TW, Schreuder GM, Breedveld FC, de Vries RR, Toes RE. An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. Arthritis Rheum 2005; 52: 2637-2644.
14. Mattey DL, Dawes PT, Gonzalez-Gay MA, Garcia-Porrua C, Thomson W, Hajeer AH, et al. HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis. J Rheumatol 2001; 28: 232-239.
15. Reviron D, Perdriger A, Toussirot E, Wendling D, Balandraud N, Guis S, et al. Influence of shared epitope-negative HLA-DRB1 alleles on genetic susceptibility to rheumatoid arthritis. Arthritis Rheum 2001; 44: 535-540.
16. Zanelli E, Breedveld FC, de Vries RR. HLA class II association with rheumatoid arthritis: facts and interpretations. Hum Immunol 2000; 61: 1254-1261.
17. Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, Jawaheer D, et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 2005; 52: 3433-3438.
18. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003; 48: 2741-2749.
19. Figueiredo MS, Silva MC, Guerreiro JF, Souza GP, Pires AC, Zago MA. The heterogeneity of the beta s cluster haplotypes in Brazil. Gene Geogr 1994; 8: 7-12.
20. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-324.
21. Louzada-Junior P, Smith AG, Hansen JA, Donadi EA. HLA-DRB1 and -DQB1 alleles in the Brazilian population of the northeastern region of the State of São Paulo. Tissue Antigens 2001; 57: 158-162.
22. Mickelson E, Smith A, McKinney S, Anderson G, Hansen JA. A comparative study of HLA-DRB1 typing by standard serology and hybridization of non-radioactive sequence-specific oligonucleotide probes to PCR-amplified DNA. Tissue Antigens 1993; 41: 86-93.
23. Kimura A, Sasazuki T. Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique. In: Tsuji K, Aizawa M, Sasazuki T (Editors), HLA 1991. Proceedings of the Eleventh International Histocompatibility Workshop Conference held in Yokohoma, Japan, November 6-13. Oxford: Oxford Science Publications; 1992. p 397-419.
24. Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 225-235.
25. Svejgaard A, Ryder LP. HLA and disease associations: detecting the strongest association. Tissue Antigens 1994; 43: 18-27.
26. Massardo L, Jacobelli S, Rodriguez L, Rivero S, Gonzalez A, Marchetti R. Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients. Ann Rheum Dis 1990; 49: 290-292.
27. Massardo L, Aguirre V, Garcia ME, Cervila V, Nicovani S, Gonzalez A, et al. Clinical expression of rheumatoid arthritis in Chilean patients. Semin Arthritis Rheum 1995; 25: 203-213.
28. Wakitani S, Imoto K, Murata N, Toda Y, Ogawa R, Ochi T. The homozygote of HLA-DRB1*0901, not its heterozygote, is associated with rheumatoid arthritis in Japanese. Scand J Rheumatol 1998; 27: 381-382.
29. Sattar MA, al-Saffar M, Guindi RT, Sugathan TN, White AG, Behbehani K. Histocompatibility antigens (A, B, C, and DR) in Arabs with rheumatoid arthritis. Dis Markers 1990; 8: 11-15.
30. Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004; 50: 3085-3092.
31. Linn-Rasker SP, van der Helm-van Mil AH, van Gaalen FA, Kloppenburg M, de Vries RR, le Cessie S, et al. Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. Ann Rheum Dis 2006; 65: 366-371.
32. Oliveira RD, Junta CM, Oliveira FR, Silva LM, Donadi EA, Louzada-Junior P. Share epitope, citrullinated cyclic peptide antibodies and smoking in Brazilian rheumatoid arthritis patients. Clin Rev Allergy Immunol 2008; 34: 32-35.
33. Zanelli E, Huizinga TW, Guerne PA, Vischer TL, Tiercy JM, Verduyn W, et al. An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition. Immunogenetics 1998; 48: 394-401.
34. Snijders A, Elferink DG, Geluk A, van Der Zanden AL, Vos K, Schreuder GM, et al. An HLA-DRB1-derived peptide associated with protection against rheumatoid arthritis is naturally processed by human APCs. J Immunol 2001; 166: 4987-4993.
35. Hohler T, Gerken G, Notghi A, Knolle P, Lubjuhn R, Taheri H, et al. MHC class II genes influence the susceptibility to chronic active hepatitis C. J Hepatol 1997; 27: 259-264.
36. van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Huizinga TW, Toes RE, de Vries RR. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum 2006; 54: 1117-1121.
37. Verpoort KN, Cheung K, Ioan-Facsinay A, van der Helmvan Mil AH, de Vries-Bouwstra JK, Allaart CF, et al. Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles. Arthritis Rheum 2007; 56: 3949-3952.
38. Yamada R, Yamamoto K. Mechanisms of disease: genetics of rheumatoid arthritis - ethnic differences in disease-associated genes. Nat Clin Pract Rheumatol 2007; 3: 644-650.
39. Gaston JS. Cytokines in arthritis - the 'big numbers' move centre stage. Rheumatology 2008; 47: 8-12.
40. Criswell LA, Saag KG, Mikuls TR, Cerhan JR, Merlino LA, Lum RF, et al. Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women. Ann Rheum Dis 2006; 65: 1163-1167.