메뉴 건너뛰기




Volumn 28, Issue 5 SUPPL. 61, 2010, Pages

Methotrexate pharmacogenetics in rheumatoid arthritis

Author keywords

Methotrexate; Pharmacogenetics; Rheumatoid arthritis

Indexed keywords

ADENOSINE DEAMINASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINOIMIDAZOLE CARBOXAMIDE RIBONUCLEOTIDE; DEOXYURIDINE PHOSPHATE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; GAMMA GLUTAMYL HYDROLASE; GENE PRODUCT; INOSINATE DEHYDROGENASE INHIBITOR; METHOTREXATE; METHOTREXATE POLYGLUTAMATE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; REDUCED FOLATE CARRIER; RIBONUCLEOTIDE; TETRAHYDROFOLIC ACID; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; ABC TRANSPORTER; CHEMOKINE RECEPTOR CXCR6; GLYCINE HYDROXYMETHYLTRANSFERASE; TOLL LIKE RECEPTOR 4;

EID: 78650548876     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (49)
  • 1
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Review
    • EVANS WE, RELLING MV: Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999;286:487-91. (Review).
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 2
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • EVANS WE, MCLEOD HL: Pharmacogenomics - drug disposition, drug targets, and side effects. N Engl J Med 2003;348:538-49.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 3
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • see comment
    • WEINBLATT ME, KREMER JM, BANKHURST AD et al.: A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999;340:253-9. (see comment).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 4
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • KREMER JM et al.: Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003;349:1907-15.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1907-1915
    • Kremer, J.M.1
  • 5
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial
    • see comment erratum appears in
    • WEINBLATT ME et al.: Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. (see comment) (erratum appears in Arthritis Rheum 2003;48:855).
    • (2003) Arthritis Rheum. , vol.48 , pp. 855
    • Weinblatt, M.E.1
  • 6
    • 0141905860 scopus 로고    scopus 로고
    • Arthritis Rheum 2003;48:35-45.
    • (2003) Arthritis Rheum. , vol.48 , pp. 35-45
  • 7
    • 0028946251 scopus 로고
    • The total costs of drug therapy for rheumatoid arthritis. A model based on costs of drug, monitoring, and toxicity. (see comment)
    • PRASHKER MJ, MEENAN RF: The total costs of drug therapy for rheumatoid arthritis. A model based on costs of drug, monitoring, and toxicity. (see comment). Arthritis Rheum 1995;38:318-25.
    • (1995) Arthritis Rheum. , vol.38 , pp. 318-325
    • Prashker, M.J.1    Meenan, R.F.2
  • 8
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • BORST P, ELFERINK RO: Mammalian ABC transporters in health and disease. Ann Rev Biochem 2002;71:537-92.
    • (2002) Ann. Rev. Biochem. , vol.71 , pp. 537-592
    • Borst, P.1    Elferink, R.O.2
  • 9
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • HOOIJBERG JH, BROXTERMAN HI, KOOL M et al.: Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 1999;59:2532-5.
    • (1999) Cancer Res. , vol.59 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.I.2    Kool, M.3
  • 10
    • 13044294031 scopus 로고    scopus 로고
    • MRP3, an organic anion transporter able to transport anti-cancer drugs
    • KOOL M, VAN DER LINDEN M, DE HAAS M et al.: MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci USA 1999;96:6914-9.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6914-6919
    • Kool, M.1    Van Der Linden, M.2    De Haas, M.3
  • 11
    • 0018874761 scopus 로고
    • Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate
    • GALIVAN J: Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate. Mol Pharmacol 1980;17:105-10.
    • (1980) Mol. Pharmacol. , vol.17 , pp. 105-110
    • Galivan, J.1
  • 12
    • 0018715411 scopus 로고
    • Human thymidylate synthetase-III. Effects of methotrexate and folate analogs
    • SZETO DW, CHENG YC, ROSOWSKY A et al.: Human thymidylate synthetase-III. Effects of methotrexate and folate analogs. Biochem Pharmacol 1979;28:2633-7.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 2633-2637
    • Szeto, D.W.1    Cheng, Y.C.2    Rosowsky, A.3
  • 13
    • 0035985787 scopus 로고    scopus 로고
    • Molecular action of methotrexate in inflammatory diseases
    • CHAN ES, CRONSTEIN BN: Molecular action of methotrexate in inflammatory diseases. Arthritis Res 2002;4:266-73.
    • (2002) Arthritis Res. , vol.4 , pp. 266-273
    • Chan, E.S.1    Cronstein, B.N.2
  • 14
    • 0033805360 scopus 로고    scopus 로고
    • A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. (see comment)
    • CHANGO A, EMERY-FILLON N, DE COURCY GP et al.: A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. (see comment). Mol Genet Metab 2000;70:310-5.
    • (2000) Mol. Genet. Metab. , vol.70 , pp. 310-315
    • Chango, A.1    Emery-Fillon, N.2    De Courcy, G.P.3
  • 15
    • 0035187308 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the human reduced folate carrier: Characterization of a high-frequency G/A variant at position 80 and transport properties of the His (27) and Arg (27) carriers
    • WHETSTINE JR, GIFFORD AJ, WITT T et al.: Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His (27) and Arg (27) carriers. Clin Cancer Res 2001;7:3416-22.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3416-3422
    • Whetstine, J.R.1    Gifford, A.J.2    Witt, T.3
  • 16
    • 25344433582 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the folate/purine synthesis pathway predict methotrexate's effects in rheumatoid arthritis (abstract)
    • DERVIEUX T, LEIN DO, PARK G et al.: Single nucleotide polymorphisms in the folate/purine synthesis pathway predict methotrexate's effects in rheumatoid arthritis (abstract). Arthritis Rheum 2003;48: S438.
    • (2003) Arthritis Rheum. , vol.48
    • Dervieux, T.1    Lein, D.O.2    Park, G.3
  • 17
    • 0242321228 scopus 로고    scopus 로고
    • Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms
    • CHAVE, KJ, RYAN TJ, CHMURA SE, GALIVAN J: Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene 2003;319:167-75.
    • (2003) Gene , vol.319 , pp. 167-175
    • Chave1    Kj2    Ryan, T.J.3    Chmura, S.E.4    Galivan, J.5
  • 18
    • 9244264949 scopus 로고    scopus 로고
    • Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis
    • DERVIEUX T, KREMER J, LEIN DO et al.: Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics 2004;14:733-9.
    • (2004) Pharmacogenetics , vol.14 , pp. 733-739
    • Dervieux, T.1    Kremer, J.2    Lein, D.O.3
  • 19
    • 4143124340 scopus 로고    scopus 로고
    • A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells
    • CHENG Q, WU B, KAGER L et al.: A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. Pharmacogenetics 2004;14:557-67.
    • (2004) Pharmacogenetics , vol.14 , pp. 557-567
    • Cheng, Q.1    Wu, B.2    Kager, L.3
  • 20
    • 65549139809 scopus 로고    scopus 로고
    • Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis
    • HAYASHI H, FUJIMAKI C, DAIMON T et al.: Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis. J Clin Pharm Ther 2009;34:355-61.
    • (2009) J. Clin. Pharm. Ther. , vol.34 , pp. 355-361
    • Hayashi, H.1    Fujimaki, C.2    Daimon, T.3
  • 21
    • 33847075831 scopus 로고    scopus 로고
    • Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients
    • VAN DER STRAATEN RJ, WESSELS JA, DE VRIES-BOUWSTRA JK et al.: Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients. Pharmacogenomics 2007;8:141-50.
    • (2007) Pharmacogenomics , vol.8 , pp. 141-150
    • Van Der Straaten, R.J.1    Wessels, J.A.2    De Vries-Bouwstra, J.K.3
  • 22
    • 13344277328 scopus 로고    scopus 로고
    • Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate
    • NORRIS MD, DE GRAAF D, HABER M et al.: Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate, Int J Cancer 1996;65:613-9.
    • (1996) Int. J. Cancer , vol.65 , pp. 613-619
    • Norris, M.D.1    De Graaf, D.2    Haber, M.3
  • 23
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • HOFFMEYER S, BURK O, VON RICHTER O et al.: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000;97:3473-8.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3
  • 24
    • 3042772026 scopus 로고    scopus 로고
    • Identification of functionally variant MDR1 alleles among European Americans and African Americans
    • KIM RB, LEAKE BF, CHOO EF et al.: Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001;70:189-99.
    • (2001) Clin. Pharmacol. Ther. , vol.70 , pp. 189-199
    • Kim, R.B.1    Leake, B.F.2    Choo, E.F.3
  • 25
    • 0034997034 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
    • TANABE M, IEIRI I, NAGATA N et al.: Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther 2001;297:1137-43.
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 1137-1143
    • Tanabe, M.1    Ieiri, I.2    Nagata, N.3
  • 26
    • 0034518362 scopus 로고    scopus 로고
    • Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    • ULRICH CM, BIGLER J, VELICER CM et al.: Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev 2000;9:1381-5.
    • (2000) Cancer Epidemiol. Biomarkers Prev. , vol.9 , pp. 1381-1385
    • Ulrich, C.M.1    Bigler, J.2    Velicer, C.M.3
  • 27
    • 33845509442 scopus 로고    scopus 로고
    • ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients
    • TAKATORI R, TAKAHASHI KA, TOKUNAGA D et al.: ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients. Clin Exp Rheumatol 2006, 24:546-54.
    • (2006) Clin. Exp. Rheumatol. , vol.24 , pp. 546-554
    • Takatori, R.1    Takahashi, K.A.2    Tokunaga, D.3
  • 28
    • 41849115973 scopus 로고    scopus 로고
    • Methotrexate pathway gene polymorphisms and their effects on methotrexate toxicity in Caucasian and African American patients with rheumatoid arthritis
    • RANGANATHAN P, CULVERHOUSE R, MARSH S et al.: Methotrexate pathway gene polymorphisms and their effects on methotrexate toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol 2008;35:550-2.
    • (2008) J. Rheumatol. , vol.35 , pp. 550-552
    • Ranganathan, P.1    Culverhouse, R.2    Marsh, S.3
  • 30
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
    • KANG SS, ZHOU J, WONG PW, KOWALISYN J, STROKOSCH G: Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Gen 1988;43:414-21.
    • (1988) Am. J. Hum. Gen. , vol.43 , pp. 414-421
    • Kang, S.S.1    Zhou, J.2    Wong, P.W.3    Kowalisyn, J.4    Strokosch, G.5
  • 32
    • 0012184216 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity, (see comments)
    • WINEGRAD S, WEISBERG I: A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity, (see comments). Circ Res 1998;83:60-72.
    • (1998) Circ. Res. , vol.83 , pp. 60-72
    • Winegrad, S.1    Weisberg, I.2
  • 33
    • 10544249877 scopus 로고    scopus 로고
    • Human methionine synthase: Cdna cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
    • LECLERC D, CAMPEAU E, GOYETTE P et al.: Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet 1996;5:1867-74.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1867-1874
    • Leclerc, D.1    Campeau, E.2    Goyette, P.3
  • 34
    • 0035864635 scopus 로고    scopus 로고
    • Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    • CHEN J, STAMPFER MJ, MA J et al.: Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 2001;154:667-72.
    • (2001) Atherosclerosis , vol.154 , pp. 667-672
    • Chen, J.1    Stampfer, M.J.2    Ma, J.3
  • 35
    • 0032713815 scopus 로고    scopus 로고
    • Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
    • HARMON DL, SHIELDS DC, WOODSIDE JV et al.: Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol 1999;17:298-309.
    • (1999) Genet. Epidemiol. , vol.17 , pp. 298-309
    • Harmon, D.L.1    Shields, D.C.2    Woodside, J.V.3
  • 36
    • 0032856882 scopus 로고    scopus 로고
    • A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
    • WILSON A, PLATT R, WU Q et al.: A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab 1999;67:317-23.
    • (1999) Mol. Genet. Metab. , vol.67 , pp. 317-323
    • Wilson, A.1    Platt, R.2    Wu, Q.3
  • 37
    • 0034904708 scopus 로고    scopus 로고
    • The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations
    • GAUGHAN DJ, KLUIJTMANS LA, BARBAUX S et al.: The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 2001;157:451-6.
    • (2001) Atherosclerosis , vol.157 , pp. 451-456
    • Gaughan, D.J.1    Kluijtmans, L.A.2    Barbaux, S.3
  • 38
    • 33646354882 scopus 로고    scopus 로고
    • Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes
    • WESSELS JA, DE VRIES-BOUWSTRA JK, HEIJMANS BT et al.: Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum 2006;54:1087-95.
    • (2006) Arthritis Rheum. , vol.54 , pp. 1087-1095
    • Wessels, J.A.1    De Vries-Bouwstra, J.K.2    Heijmans, B.T.3
  • 39
    • 65649111229 scopus 로고    scopus 로고
    • Metaanalysis of methylenetetrahydrofolate reductase (MTH-FR) polymorphisms affecting methotrexate toxicity
    • FISHER MC, CRONSTEIN BN: Metaanalysis of methylenetetrahydrofolate reductase (MTH-FR) polymorphisms affecting methotrexate toxicity. J Rheumatol 2009;36:539-45.
    • (2009) J. Rheumatol. , vol.36 , pp. 539-545
    • Fisher, M.C.1    Cronstein, B.N.2
  • 40
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase
    • HORIE N, AIBA H, OGURO K, HOJO H, TAKEISHI K: Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 1995, 20:191-7.
    • (1995) Cell. Struct. Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3    Hojo, H.4    Takeishi, K.5
  • 41
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
    • KAWAKAMI K, OMURA K, KANEHIRA E, WATANABE Y: Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res 1999;19:3249-52.
    • (1999) Anticancer Res. , vol.19 , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, Y.4
  • 42
    • 0035750549 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
    • PULLARKAT ST, STOEHLMACHER J, GHADERI V et al.: Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 2001;1:65-70.
    • (2001) Pharmacogenomics J. , vol.1 , pp. 65-70
    • Pullarkat, S.T.1    Stoehlmacher, J.2    Ghaderi, V.3
  • 43
    • 0842268403 scopus 로고    scopus 로고
    • The role of thymidylate synthase asamolecularbiomarker. (comment)
    • Di PAOLO A, CHU E: The role of thymidylate synthase asamolecularbiomarker. (comment). Clin Cancer Res 2004, 10:411-2.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 411-412
    • Di Paolo, A.1    Chu, E.2
  • 44
    • 4444376725 scopus 로고    scopus 로고
    • Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    • DERVIEUX T, FURST D, LEIN DO et al.: Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004;50:2766-74.
    • (2004) Arthritis Rheum. , vol.50 , pp. 2766-2774
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3
  • 45
    • 0034968527 scopus 로고    scopus 로고
    • Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?
    • HEIL SG, VAN DER PUT NM, WAAS ET et al.: Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Mol Genet Metab 2001;73:164-72.
    • (2001) Mol. Genet. Metab. , vol.73 , pp. 164-172
    • Heil, S.G.1    Van Der Put, N.M.2    Waas, E.T.3
  • 46
    • 32444436350 scopus 로고    scopus 로고
    • Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis
    • WEISMAN MH, FURST DE, PARK GS et al.: Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum 2006;54:607-12.
    • (2006) Arthritis Rheum. , vol.54 , pp. 607-612
    • Weisman, M.H.1    Furst, D.E.2    Park, G.S.3
  • 47
    • 33749370785 scopus 로고    scopus 로고
    • Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recentonset rheumatoid arthritis
    • WESSELS JA, KOOLOOS WM, DE JONGE R et al.: Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recentonset rheumatoid arthritis. Arthritis Rheum 2006;54:2830-9.
    • (2006) Arthritis Rheum. , vol.54 , pp. 2830-2839
    • Wessels, J.A.1    Kooloos, W.M.2    De Jonge, R.3
  • 48
    • 47849128459 scopus 로고    scopus 로고
    • Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX
    • HIDER SL, THOMSON W, MACK LF et al.: Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX. Rheumatology (Oxford) 2008;47:1156-9.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 1156-1159
    • Hider, S.L.1    Thomson, W.2    Mack, L.F.3
  • 49
    • 33747805632 scopus 로고    scopus 로고
    • Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis
    • HUGHES LB, BEASLEY TM, PATEL H et al.: Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis 2006;65:1213-8.
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 1213-1218
    • Hughes, L.B.1    Beasley, T.M.2    Patel, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.