Radio-deoxynucleoside analogs used for imaging tk expression in a transgenic mouse model of induced hepatocellular carcinoma

Theranostics

Volumn 2, Issue 6, 2012, Pages 597-606

  Tian, Haibin ^a   Lu, Xincheng ^b   Guo, Hong ^b   Corn, David ^a,b   Molter, Joseph ^a,b   Wang, Bingcheng ^b   Luo, Guangbin ^b   Lee, Zhenghong ^a,b  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Deoxynucleoside Analogs; Hepatocellular Carcinoma; Reporter Gene Imaging

Indexed keywords

1 (2' DEOXY 2' FLUORO BETA DEXTRO ARABINOFURANOSYL)THYMINE F 18; 1 (2' DEOXY 2' FLUORO BETA LEVO ARABINOFURANOSYL)THYMINE F 18; 9 [4 FLUORO 3 (HYDROXYMETHYL)BUTYL]GUANINE F 18; ALPHA FETOPROTEIN; FIREFLY LUCIFERASE; THYMIDINE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

AFP GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CELL PROLIFERATION; CONTROLLED STUDY; DIAGNOSTIC VALUE; GAMMA SCINTIGRAPHY; GENE EXPRESSION; GENE TARGETING; HERPES VIRUS; ISOTOPE LABELING; LIVER CELL; LIVER CELL CARCINOMA; MOLECULAR IMAGING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROMOTER REGION; REPORTER GENE; SIGNAL NOISE RATIO; TK GENE; TRANSGENIC MOUSE;

EID: 84864523118     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.3371     Document Type: Article

References (20)

1. Etiemble J, Degott C, Renard CA, Fourel G, Shamoon B, Vitvitski-Trepo L, et al. Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion. Oncogene. 1994; 9: 727-37.
2. Terradillos O, Billet O, Renard CA, Levy R, Molina T, Briand P, et al. The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene. 1997; 14: 395-404. doi:10.1038/sj.onc.1200850.
3. Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell. 2004; 6: 229-40. doi:10.1016/j.ccr.2004.08.019 S1535610804002417 [pii].
4. Holland EC. Mouse models of human cancer as tools in drug development. Cancer Cell. 2004; 6: 197-8. doi:10.1016/j.ccr.2004.09.004 S1535610804002454 [pii].
5. Lu X, Guo H, Molter J, Miao H, Gerber L, Hu Y, et al. Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver. J Hepatol. 2011; 55: 96-102. doi:S0168-8278(10)01081-0 [pii] 10.1016/j.jhep.2010.10.020.
6. Barlow JF. Alpha fetoprotein (AFP). S D J Med. 1978; 31: 33.
7. Blasberg RG. In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations. Nucl Med Biol. 2003; 30: 879-88. doi:S096980510300115X [pii].
8. Blasberg RG. Molecular imaging and cancer. Mol Cancer Ther. 2003; 2: 335-43.
9. Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer. 2002; 2: 683-93. doi:10.1038/nrc882 nrc882 [pii].
10. Choi SR, Zhuang ZP, Chacko AM, Acton PD, Tjuvajev-Gelovani J, Doubrovin M, et al. SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1). Acad Radiol. 2005; 12: 798-805. doi:S1076-6332(05)00371-5 [pii] 10.1016/j.acra.2005.04.010.
11. Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, et al. Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU. Nat Protoc. 2007; 2: 416-23. doi:nprot.2007.49 [pii] 10.1038/nprot.2007.49.
12. Gambhir SS, Herschman HR, Cherry SR, Barrio JR, Satyamurthy N, Toyokuni T, et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia. 2000; 2: 118-38.
13. Gambhir SS, Bauer E, Black ME, Liang Q, Kokoris MS, Barrio JR, et al. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci U S A. 2000; 97: 2785-90. doi:97/6/2785 [pii].
14. Nishii R, Volgin AY, Mawlawi O, Mukhopadhyay U, Pal A, Bornmann W, et al. Evaluation of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-beta-L: -arabinofuranosyluracil ([18F]-L: -FMAU) as a PET imaging agent for cellular proliferation: comparison with [18F]-D: -FMAU and [18F]FLT. Eur J Nucl Med Mol Imaging. 2008; 35: 990-8. doi:10.1007/s00259-007-0649-1.
15. Shiue GG, Shiue CY, Lee RL, MacDonald D, Hustinx R, Eck SL, et al. A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy- 2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy. Nucl Med Biol. 2001; 28: 875-83. doi:S0969-8051(01)00253-0 [pii].
16. Conti PS, Alauddin MM, Fissekis JR, Schmall B, Watanabe KA. Synthesis of 2'-fluoro-5-[11C]-methyl-1-beta-D-arabinofuranosyluracil ([11C]- FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET. Nucl Med Biol. 1995; 22: 783-9. doi:0969-8051(95)00017-R [pii].
17. Nimmagadda S, Mangner TJ, Sun H, Klecker RW, Jr., Muzik O, Lawhorn-Crews JM, et al. Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs. J Nucl Med. 2005; 46: 1916-22. doi:46/11/1916 [pii].
18. Tehrani OS, Muzik O, Heilbrun LK, Douglas KA, Lawhorn-Crews JM, Sun H, et al. Tumor imaging using 1-(2'-deoxy-2'-18F-fluoro-beta-D-arabinofuranosyl)thymine and PET. J Nucl Med. 2007; 48: 1436-41. doi:48/9/1436 [pii] 10.2967/jnumed.107.042762.
19. Mangner TJ, Klecker RW, Anderson L, Shields AF. Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU. Nucl Med Biol. 2003; 30: 215-24.
20. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, et al. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med. 2002; 43: 1072-83.