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Volumn 39, Issue 1, 2012, Pages 23-30

Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals

Author keywords

Apoptosis; Calcium; Hippocampus; Sleep deprivation; Sleep restriction

Indexed keywords

CALCIUM; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; GLUTAMIC ACID; PROTEIN BAX; PROTEIN BCL 2;

EID: 84864522816     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.01.018     Document Type: Article
Times cited : (23)

References (69)
  • 1
    • 76749154427 scopus 로고    scopus 로고
    • Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons
    • Abramov A.Y., Duchen M.R. Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons. Biochim Biophys Acta 2010, 1800(3):297-304.
    • (2010) Biochim Biophys Acta , vol.1800 , Issue.3 , pp. 297-304
    • Abramov, A.Y.1    Duchen, M.R.2
  • 2
    • 77949267093 scopus 로고    scopus 로고
    • Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
    • Alberdi E., Sánchez-Gómez M.V., Cavaliere F., Pérez-Samartín A., Zugaza J.L., Trullas R., et al. Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. Cell Calcium 2010, 47(3):264-272.
    • (2010) Cell Calcium , vol.47 , Issue.3 , pp. 264-272
    • Alberdi, E.1    Sánchez-Gómez, M.V.2    Cavaliere, F.3    Pérez-Samartín, A.4    Zugaza, J.L.5    Trullas, R.6
  • 3
    • 0842305079 scopus 로고    scopus 로고
    • Age-related effects on genital reflexes induced by paradoxical sleep deprivation and cocaine in rats
    • Andersen M.L., Bignotto M., Papale L.A., Tufik S. Age-related effects on genital reflexes induced by paradoxical sleep deprivation and cocaine in rats. Exp Gerontol 2004, 39:233-237.
    • (2004) Exp Gerontol , vol.39 , pp. 233-237
    • Andersen, M.L.1    Bignotto, M.2    Papale, L.A.3    Tufik, S.4
  • 4
    • 34447625748 scopus 로고    scopus 로고
    • Ethical and Practical Principles on the Use of Laboratory Animals
    • Universidade Federal de São Paulo (editor), São Paulo;
    • Andersen ML, D'Almeida V, Ko GM, Kawakami R, Martins PJ, Magalhaes LE, et al. Ethical and Practical Principles on the Use of Laboratory Animals, Universidade Federal de São Paulo (editor), São Paulo; 2004b.
    • (2004)
    • Andersen, M.L.1    D'Almeida, V.2    Ko, G.M.3    Kawakami, R.4    Martins, P.J.5    Magalhaes, L.E.6
  • 6
    • 33748793921 scopus 로고    scopus 로고
    • Increased apoptosis in rat brain after rapid eye movement sleep loss
    • Biswas S., Mishra P., Mallick B.N. Increased apoptosis in rat brain after rapid eye movement sleep loss. Neuroscience 2006, 142(2):315-331.
    • (2006) Neuroscience , vol.142 , Issue.2 , pp. 315-331
    • Biswas, S.1    Mishra, P.2    Mallick, B.N.3
  • 7
    • 0029560585 scopus 로고
    • We are chronically sleep deprived
    • Bonnet M.H., Arand D.L. We are chronically sleep deprived. Sleep 1995, 18(10):908-911.
    • (1995) Sleep , vol.18 , Issue.10 , pp. 908-911
    • Bonnet, M.H.1    Arand, D.L.2
  • 8
    • 0023499910 scopus 로고
    • Sleep and performance in young adults and older normals and insomniacs during acute sleep loss and recovery
    • Bonnet M.H., Rosa R.R. Sleep and performance in young adults and older normals and insomniacs during acute sleep loss and recovery. Biol Psychol 1987, 25(2):153-172.
    • (1987) Biol Psychol , vol.25 , Issue.2 , pp. 153-172
    • Bonnet, M.H.1    Rosa, R.R.2
  • 10
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 11
    • 34248233012 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels
    • Brewer L.D., Thibault O., Staton J., Thibault V., Rogers J.T., Garcia-Ramos G., Kraner S., Landfield P.W., Porter N.M. Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels. Brain Res 2007, 1151:20-31.
    • (2007) Brain Res , vol.1151 , pp. 20-31
    • Brewer, L.D.1    Thibault, O.2    Staton, J.3    Thibault, V.4    Rogers, J.T.5    Garcia-Ramos, G.6    Kraner, S.7    Landfield, P.W.8    Porter, N.M.9
  • 12
    • 0029995776 scopus 로고    scopus 로고
    • Insufficient sleep in the general population
    • Broman J.E., Lundh L.G., Hetta J. Insufficient sleep in the general population. Neurophysiol Clin 1996, 26(1):30-39.
    • (1996) Neurophysiol Clin , vol.26 , Issue.1 , pp. 30-39
    • Broman, J.E.1    Lundh, L.G.2    Hetta, J.3
  • 13
    • 0029827804 scopus 로고    scopus 로고
    • Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells
    • Budd S.L., Nicholls D.G. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 1996, 67(6):2282-2291.
    • (1996) J Neurochem , vol.67 , Issue.6 , pp. 2282-2291
    • Budd, S.L.1    Nicholls, D.G.2
  • 14
    • 29644438259 scopus 로고    scopus 로고
    • Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
    • Chen C., Hardy M., Zhang J., LaHoste G.J., Bazan N.G. Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments. Biochem Biophys Res Commun 2006, 340:435-440.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 435-440
    • Chen, C.1    Hardy, M.2    Zhang, J.3    LaHoste, G.J.4    Bazan, N.G.5
  • 15
    • 0033523431 scopus 로고    scopus 로고
    • No evidence of brain cell degeneration after long-term sleep deprivation in rats
    • Cirelli C., Shaw P.J., Rechtschaffen A., Tononi G. No evidence of brain cell degeneration after long-term sleep deprivation in rats. Brain Res 1999, 840:184-193.
    • (1999) Brain Res , vol.840 , pp. 184-193
    • Cirelli, C.1    Shaw, P.J.2    Rechtschaffen, A.3    Tononi, G.4
  • 16
    • 0022412356 scopus 로고
    • Stress induced by three procedures of deprivation of paradoxical sleep
    • Coenen A.M., van Luijtelaar E.L. Stress induced by three procedures of deprivation of paradoxical sleep. Physiol Behav 1985, 35(4):501-504.
    • (1985) Physiol Behav , vol.35 , Issue.4 , pp. 501-504
    • Coenen, A.M.1    van Luijtelaar, E.L.2
  • 17
    • 76749171704 scopus 로고    scopus 로고
    • Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior
    • Cortese B.M., Mitchell T.R., Galloway M.P., Prevost K.E., Fang J., Moore G.J., et al. Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior. Physiol Behav 2010, 99(4):445-450.
    • (2010) Physiol Behav , vol.99 , Issue.4 , pp. 445-450
    • Cortese, B.M.1    Mitchell, T.R.2    Galloway, M.P.3    Prevost, K.E.4    Fang, J.5    Moore, G.J.6
  • 19
    • 38949207324 scopus 로고    scopus 로고
    • Aging-related sleep changes
    • Espiritu J.R. Aging-related sleep changes. Clin Geriatr Med 2008, 24(1):1-14.
    • (2008) Clin Geriatr Med , vol.24 , Issue.1 , pp. 1-14
    • Espiritu, J.R.1
  • 20
    • 43649083316 scopus 로고    scopus 로고
    • The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway
    • Ferreiro E., Oliveira C.R., Pereira C.M. The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol Dis 2008, 30(3):331-342.
    • (2008) Neurobiol Dis , vol.30 , Issue.3 , pp. 331-342
    • Ferreiro, E.1    Oliveira, C.R.2    Pereira, C.M.3
  • 21
    • 33750469522 scopus 로고    scopus 로고
    • The mystery of sleep function: current perspectives and future directions
    • Frank M.G. The mystery of sleep function: current perspectives and future directions. Rev Neurosci 2006, 17(4):375-392.
    • (2006) Rev Neurosci , vol.17 , Issue.4 , pp. 375-392
    • Frank, M.G.1
  • 22
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992, 119(3):493-501.
    • (1992) J Cell Biol , vol.119 , Issue.3 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 23
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985, 260(6):3440-3450.
    • (1985) J Biol Chem , vol.260 , Issue.6 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 24
    • 77952600258 scopus 로고    scopus 로고
    • Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation
    • Hagewoud R., Havekes R., Novati A., Keijser J.N., Van der Zee E.A., Meerlo P. Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation. J Sleep Res 2010, 19(2):280-288.
    • (2010) J Sleep Res , vol.19 , Issue.2 , pp. 280-288
    • Hagewoud, R.1    Havekes, R.2    Novati, A.3    Keijser, J.N.4    Van der Zee, E.A.5    Meerlo, P.6
  • 25
    • 58549093739 scopus 로고    scopus 로고
    • Impaired calcium homeostasis in aged hippocampal neurons
    • Hajieva P., Kuhlmann C., Luhmann H.J., Behl C. Impaired calcium homeostasis in aged hippocampal neurons. Neurosci Lett 2009, 451(2):119-123.
    • (2009) Neurosci Lett , vol.451 , Issue.2 , pp. 119-123
    • Hajieva, P.1    Kuhlmann, C.2    Luhmann, H.J.3    Behl, C.4
  • 26
    • 0036010321 scopus 로고    scopus 로고
    • Sleep deprivation does not affect indices of necrosis or apoptosis in rat brain
    • Hipólide D.C., D'Almeida V., Raymond R., Tufik S., Nóbrega J.N. Sleep deprivation does not affect indices of necrosis or apoptosis in rat brain. Int J Neurosci 2002, 112:155-166.
    • (2002) Int J Neurosci , vol.112 , pp. 155-166
    • Hipólide, D.C.1    D'Almeida, V.2    Raymond, R.3    Tufik, S.4    Nóbrega, J.N.5
  • 27
    • 0032850805 scopus 로고    scopus 로고
    • Age-related alteration of intracellular ATP maintenance in the cell suspensions of mice cerebral cortex
    • Joo H.J., Ma J.Y., Choo Y.G., Choi B.K., Jung K.Y. Age-related alteration of intracellular ATP maintenance in the cell suspensions of mice cerebral cortex. Mech Ageing Dev 1999, 110(1-2):1-12.
    • (1999) Mech Ageing Dev , vol.110 , Issue.1-2 , pp. 1-12
    • Joo, H.J.1    Ma, J.Y.2    Choo, Y.G.3    Choi, B.K.4    Jung, K.Y.5
  • 28
    • 33845268266 scopus 로고    scopus 로고
    • Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function
    • Kopp C., Longordo F., Nicholson J.R., Lüthi A. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J Neurosci 2006, 26(48):12456-12465.
    • (2006) J Neurosci , vol.26 , Issue.48 , pp. 12456-12465
    • Kopp, C.1    Longordo, F.2    Nicholson, J.R.3    Lüthi, A.4
  • 29
    • 0345276414 scopus 로고    scopus 로고
    • Bcl-2-family proteins and the role of mitochondria in apoptosis
    • Kuwana T., Newmeyer D.D. Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 2003, 15(6):691-699.
    • (2003) Curr Opin Cell Biol , vol.15 , Issue.6 , pp. 691-699
    • Kuwana, T.1    Newmeyer, D.D.2
  • 30
    • 67650505038 scopus 로고    scopus 로고
    • Neurobiological changes in the hippocampus during normative aging
    • Lister J.P., Barnes C.A. Neurobiological changes in the hippocampus during normative aging. Arch Neurol 2009, 66(7):829-833.
    • (2009) Arch Neurol , vol.66 , Issue.7 , pp. 829-833
    • Lister, J.P.1    Barnes, C.A.2
  • 32
    • 18044365775 scopus 로고    scopus 로고
    • Sleep homeostasis in rats assessed by a long-term intermittent paradoxical sleep deprivation protocol
    • Machado R.B., Suchecki D., Tufik S. Sleep homeostasis in rats assessed by a long-term intermittent paradoxical sleep deprivation protocol. Behav Brain Res 2005, 160:356-364.
    • (2005) Behav Brain Res , vol.160 , pp. 356-364
    • Machado, R.B.1    Suchecki, D.2    Tufik, S.3
  • 33
    • 0032168690 scopus 로고    scopus 로고
    • Aging of glutamate receptors: correlations between binding and spatial memory performance in mice
    • Magnusson K.R. Aging of glutamate receptors: correlations between binding and spatial memory performance in mice. Mech Ageing Dev 1998, 104(3):227-248.
    • (1998) Mech Ageing Dev , vol.104 , Issue.3 , pp. 227-248
    • Magnusson, K.R.1
  • 34
    • 0037186456 scopus 로고    scopus 로고
    • Age-related changes in the protein expression of subunits of the NMDA receptor
    • Magnusson K.R., Nelson S.E., Young A.B. Age-related changes in the protein expression of subunits of the NMDA receptor. Brain Res Mol Brain Res 2002, 99(1):40-45.
    • (2002) Brain Res Mol Brain Res , vol.99 , Issue.1 , pp. 40-45
    • Magnusson, K.R.1    Nelson, S.E.2    Young, A.B.3
  • 35
    • 78049493731 scopus 로고    scopus 로고
    • Selective vulnerabilities of N-methyl-d-aspartate (NMDA) receptors during brain aging
    • Magnusson K.R., Brim B.L., Das S.R. Selective vulnerabilities of N-methyl-d-aspartate (NMDA) receptors during brain aging. Front Aging Neurosci 2010, 2:11-25.
    • (2010) Front Aging Neurosci , vol.2 , pp. 11-25
    • Magnusson, K.R.1    Brim, B.L.2    Das, S.R.3
  • 37
    • 0142244116 scopus 로고    scopus 로고
    • Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons
    • McDermott C.M., LaHoste G.J., Chen C., Musto A., Bazan N.G., Magee J.C. Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci 2003, 23(29):9687-9695.
    • (2003) J Neurosci , vol.23 , Issue.29 , pp. 9687-9695
    • McDermott, C.M.1    LaHoste, G.J.2    Chen, C.3    Musto, A.4    Bazan, N.G.5    Magee, J.C.6
  • 38
    • 33645882233 scopus 로고    scopus 로고
    • Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus
    • McDermott C.M., Hardy M.N., Bazan N.G., Magee J.C. Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus. J Physiol 2006, 570(Pt 3):553-565.
    • (2006) J Physiol , vol.570 , Issue.PART 3 , pp. 553-565
    • McDermott, C.M.1    Hardy, M.N.2    Bazan, N.G.3    Magee, J.C.4
  • 39
    • 65849504555 scopus 로고    scopus 로고
    • BCL-2 and BAX proteins expression throughout the light-dark cycle and modifications induced by sleep deprivation and rebound in adult rat brain
    • Montes-Rodríguez C.J., Alavez S., Soria-Gómez E., Rueda-Orozco P.E., Guzman K., Morán J., et al. BCL-2 and BAX proteins expression throughout the light-dark cycle and modifications induced by sleep deprivation and rebound in adult rat brain. J Neurosci Res 2009, 87(7):1602-1609.
    • (2009) J Neurosci Res , vol.87 , Issue.7 , pp. 1602-1609
    • Montes-Rodríguez, C.J.1    Alavez, S.2    Soria-Gómez, E.3    Rueda-Orozco, P.E.4    Guzman, K.5    Morán, J.6
  • 40
    • 2542441559 scopus 로고    scopus 로고
    • Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons
    • Murchison D., Zawieja D.C., Griffith W.H. Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons. Cell Calcium 2004, 36(1):61-75.
    • (2004) Cell Calcium , vol.36 , Issue.1 , pp. 61-75
    • Murchison, D.1    Zawieja, D.C.2    Griffith, W.H.3
  • 41
    • 48549090526 scopus 로고    scopus 로고
    • Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
    • Naidoo N., Ferber M., Master M., Zhu Y., Pack A.I. Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling. J Neurosci 2008, 28(26):6539-6548.
    • (2008) J Neurosci , vol.28 , Issue.26 , pp. 6539-6548
    • Naidoo, N.1    Ferber, M.2    Master, M.3    Zhu, Y.4    Pack, A.I.5
  • 42
    • 84856088237 scopus 로고    scopus 로고
    • Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-methyl-D-aspartate receptor-mediated neurotoxicity
    • Novati A., Hulshof H.J., Granic I., Meerlo P. Chronic partial sleep deprivation reduces brain sensitivity to glutamate N-methyl-D-aspartate receptor-mediated neurotoxicity. J Sleep Res 2012, 21(1):3-9.
    • (2012) J Sleep Res , vol.21 , Issue.1 , pp. 3-9
    • Novati, A.1    Hulshof, H.J.2    Granic, I.3    Meerlo, P.4
  • 45
    • 3042595335 scopus 로고    scopus 로고
    • Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons
    • Pivovarova N.B., Nguyen H.V., Winters C.A., Brantner C.A., Smith C.L., Andrews S.B. Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J Neurosci 2004, 24(24):5611-5622.
    • (2004) J Neurosci , vol.24 , Issue.24 , pp. 5611-5622
    • Pivovarova, N.B.1    Nguyen, H.V.2    Winters, C.A.3    Brantner, C.A.4    Smith, C.L.5    Andrews, S.B.6
  • 47
    • 62549124542 scopus 로고    scopus 로고
    • Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus
    • Ravassard P., Pachoud B., Comte J.C., Mejia-Perez C., Scoté-Blachon C., Gay N., et al. Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus. Sleep 2009, 32(2):227-240.
    • (2009) Sleep , vol.32 , Issue.2 , pp. 227-240
    • Ravassard, P.1    Pachoud, B.2    Comte, J.C.3    Mejia-Perez, C.4    Scoté-Blachon, C.5    Gay, N.6
  • 48
    • 0035054493 scopus 로고    scopus 로고
    • Glutamatergic neurotransmission in aging: a critical perspective
    • Segovia G., Porras A., Del Arco A., Mora F. Glutamatergic neurotransmission in aging: a critical perspective. Mech Ageing Dev 2001, 122(1):1-29.
    • (2001) Mech Ageing Dev , vol.122 , Issue.1 , pp. 1-29
    • Segovia, G.1    Porras, A.2    Del Arco, A.3    Mora, F.4
  • 49
    • 43249112268 scopus 로고    scopus 로고
    • Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats
    • Singh R., Kiloung J., Singh S., Sharma D. Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats. Biogerontology 2008, 9(3):153-162.
    • (2008) Biogerontology , vol.9 , Issue.3 , pp. 153-162
    • Singh, R.1    Kiloung, J.2    Singh, S.3    Sharma, D.4
  • 51
    • 52049101111 scopus 로고    scopus 로고
    • Evaluation of some cell death features by real time real space microscopy
    • Smaili S.S., Rosenstock T.R., Hsu Y.T. Evaluation of some cell death features by real time real space microscopy. Methods Enzymol 2008, 442:27-50.
    • (2008) Methods Enzymol , vol.442 , pp. 27-50
    • Smaili, S.S.1    Rosenstock, T.R.2    Hsu, Y.T.3
  • 52
    • 79955481253 scopus 로고    scopus 로고
    • The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats
    • Süer C., Dolu N., Artis A.S., Sahin L., Yilmaz A., Cetin A. The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats. Neurosci Res 2011, 70(1):71-77.
    • (2011) Neurosci Res , vol.70 , Issue.1 , pp. 71-77
    • Süer, C.1    Dolu, N.2    Artis, A.S.3    Sahin, L.4    Yilmaz, A.5    Cetin, A.6
  • 53
    • 59949093500 scopus 로고    scopus 로고
    • Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep-deprivation
    • Tadavarty R., Kaan T.K., Sastry B.R. Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep-deprivation. Exp Neurol 2009, 216(1):239-242.
    • (2009) Exp Neurol , vol.216 , Issue.1 , pp. 239-242
    • Tadavarty, R.1    Kaan, T.K.2    Sastry, B.R.3
  • 54
    • 0031813589 scopus 로고    scopus 로고
    • Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells
    • Tan S., Wood M., Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem 1998, 71(1):95-105.
    • (1998) J Neurochem , vol.71 , Issue.1 , pp. 95-105
    • Tan, S.1    Wood, M.2    Maher, P.3
  • 55
    • 72649104727 scopus 로고    scopus 로고
    • Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine
    • Tartar J.L., McKenna J.T., Ward C.P., McCarley R.W., Strecker R.E., Brown R.E. Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine. Neurosci Lett 2010, 469(1):1-5.
    • (2010) Neurosci Lett , vol.469 , Issue.1 , pp. 1-5
    • Tartar, J.L.1    McKenna, J.T.2    Ward, C.P.3    McCarley, R.W.4    Strecker, R.E.5    Brown, R.E.6
  • 56
    • 17244381089 scopus 로고    scopus 로고
    • Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons
    • Thees S., Hubbard G.B., Winckler J., Schultz C., Rami A. Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restor Neurol Neurosci 2005, 23(1):1-9.
    • (2005) Restor Neurol Neurosci , vol.23 , Issue.1 , pp. 1-9
    • Thees, S.1    Hubbard, G.B.2    Winckler, J.3    Schultz, C.4    Rami, A.5
  • 57
    • 33745287476 scopus 로고    scopus 로고
    • Normal brain ageing: models and mechanisms
    • Toescu E.C. Normal brain ageing: models and mechanisms. Philos Trans R Soc Lond B Biol Sci 2005, 360(1464):2347-2354.
    • (2005) Philos Trans R Soc Lond B Biol Sci , vol.360 , Issue.1464 , pp. 2347-2354
    • Toescu, E.C.1
  • 58
    • 14944356256 scopus 로고    scopus 로고
    • 2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing
    • 2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing. J Cell Mol Med 2004, 8(2):181-190.
    • (2004) J Cell Mol Med , vol.8 , Issue.2 , pp. 181-190
    • Toescu, E.C.1    Verkhratsky, A.2
  • 59
    • 34248997850 scopus 로고    scopus 로고
    • The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging
    • Toescu E.C., Verkhratsky A. The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell 2007, 6(3):267-273.
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 267-273
    • Toescu, E.C.1    Verkhratsky, A.2
  • 60
  • 62
    • 70349316514 scopus 로고    scopus 로고
    • Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
    • Tufik S., Andersen M.L., Bittencourt L.R., Mello M.T. Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research. An Acad Bras Cienc 2009, 81(3):521-538.
    • (2009) An Acad Bras Cienc , vol.81 , Issue.3 , pp. 521-538
    • Tufik, S.1    Andersen, M.L.2    Bittencourt, L.R.3    Mello, M.T.4
  • 63
    • 74049112766 scopus 로고    scopus 로고
    • Alterations in calcium signaling and a decrease in Bcl-2 expression: possible correlation with apoptosis in aged striatum
    • Ureshino R.P., Bertoncini C.R., Fernandes M.J., Abdalla F.M., Porto C.S., Hsu Y.T., et al. Alterations in calcium signaling and a decrease in Bcl-2 expression: possible correlation with apoptosis in aged striatum. J Neurosci Res 2010, 88(2):438-447.
    • (2010) J Neurosci Res , vol.88 , Issue.2 , pp. 438-447
    • Ureshino, R.P.1    Bertoncini, C.R.2    Fernandes, M.J.3    Abdalla, F.M.4    Porto, C.S.5    Hsu, Y.T.6
  • 64
    • 0019839041 scopus 로고
    • Paradoxical sleep deprivation and locomotor activity in rats
    • Van Hulzen Z.J., Coenen A.M. Paradoxical sleep deprivation and locomotor activity in rats. Physiol Behav 1981, 27(4):741-744.
    • (1981) Physiol Behav , vol.27 , Issue.4 , pp. 741-744
    • Van Hulzen, Z.J.1    Coenen, A.M.2
  • 66
    • 52749096126 scopus 로고    scopus 로고
    • Cognitive consequences of sleep and sleep loss
    • Walker M.P. Cognitive consequences of sleep and sleep loss. Sleep Med 2008, 9(Suppl 1):S29-S34.
    • (2008) Sleep Med , vol.9 , Issue.SUPPL 1
    • Walker, M.P.1
  • 67
    • 80055034564 scopus 로고    scopus 로고
    • Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex
    • Winters B.D., Huang Y.H., Dong Y., Krueger J.M. Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex. Brain Res 2011, 420:1-7.
    • (2011) Brain Res , vol.420 , pp. 1-7
    • Winters, B.D.1    Huang, Y.H.2    Dong, Y.3    Krueger, J.M.4
  • 68
    • 0037115050 scopus 로고    scopus 로고
    • 2+ homeostasis in aged cerebellar granule neurons in brain slices
    • 2+ homeostasis in aged cerebellar granule neurons in brain slices. J Neurosci 2002, 22(24):10761-10771.
    • (2002) J Neurosci , vol.22 , Issue.24 , pp. 10761-10771
    • Xiong, J.1    Verkhratsky, A.2    Toescu, E.C.3
  • 69
    • 1242271240 scopus 로고    scopus 로고
    • Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro
    • Xiong J., Camello P.J., Verkhratsky A., Toescu E.C. Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro. Neurobiol Aging 2004, 25(3):349-359.
    • (2004) Neurobiol Aging , vol.25 , Issue.3 , pp. 349-359
    • Xiong, J.1    Camello, P.J.2    Verkhratsky, A.3    Toescu, E.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.