DNA Oxidation, Antioxidant Effects, and DNA Repair Measured with the Comet Assay

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications

Volumn , Issue , 2010, Pages 261-282

  Dušinská, Mária ^a,b   Collins, Andrew R ^c  

^a NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

^b SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Biomarker choice in human biomonitoring studies nature of study and aims of investigation; Comet assay limitations and range of BER and NER activities in human lymphocytes; Comet assay, biomarker assay in studies of exposure of humans to environmental mutagens carcinogens; Comet assay, its application to study of environmental and occupational exposure to mutagens; DNA oxidation, antioxidant effects, and DNA repair measured with comet assay; DNA oxidation, exposure to environmental mutagens damage, being attack by endogenous free radicals; Genetic polymorphism influence on DNA damage and repair; Link between fruit and vegetable consumption reduced cancer incidence, attributed to high content of antioxidants; Measuring DNA oxidation as biomarker, chromatographic: GC MS and HPLC with electrochemical detection; Oxidative DNA damage, measurable in human cells by HPLC or FPG based assays

Indexed keywords

EID: 84886521369     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780813814438.ch16     Document Type: Chapter

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