DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326

Mutation Research - DNA Repair

Volumn 486, Issue 3, 2001, Pages 207-216

  Janssen, Kai ^a   Schlink, Kirsten ^a   Götte, Walter ^a   Hippler, Birgit ^a   Kaina, Bernd ^a   Oesch, Franz ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

7, 8 Dihydro 8 oxoguanine; DNA repair; Genetic polymorphism; Human OGG1; Lymphocytes

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANINE DEOXYRIBONUCLEIC ACID GLYCOSYLASE 1; CYSTEINE; DNA; DNA GLYCOSYLTRANSFERASE; ISOPROTEIN; OLIGONUCLEOTIDE; SERINE; UNCLASSIFIED DRUG;

ADULT; ANALYTIC METHOD; ARTICLE; CANCER RISK; CAUCASIAN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA TRANSCRIPTION; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOCYTE PRESERVATION; MALE; MUTATION RATE; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SEX DIFFERENCE; SMOKING HABIT; STRUCTURE ANALYSIS;

ALLELES; AMINO ACID SEQUENCE; BASE SEQUENCE; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; GENE FREQUENCY; HUMANS; ISOENZYMES; LYMPHOCYTES; MALE; N-GLYCOSYL HYDROLASES; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035833661     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(01)00096-9     Document Type: Article

References (45)

1. Instability and decay of the primary structure of DNA
2. Human cancer syndromes: Clues to the origin and nature of cancer
3. Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance
4. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7, 8-dihydro-8-oxoguanine)
5. Mutagenesis by 8-oxoguanine: An enemy within
6. 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity
7. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): Excision of purine lesions in DNA produced by ionising radiation or photosensitization
8. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7, 8-dihydro-8-oxoguanine and 2, 6-diamino-4-hydroxy-5-N-methylformamidopyrimidine
9. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily
10. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
11. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
12. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue
13. Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage
14. Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7, 8-dihydro-8-oxoguanine and abasic sites
15. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer
16. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae
17. Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
18. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
19. 8-Hydroxyguanine (7, 8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity
20. Repair of 8-oxoguanine in DNA is deficient in Cockayne's syndrome group B cells
21. Three distinct regions involved in 3p deletion in human lung cancer
22. Detailed deletion mapping of the short arm of chromosome 3 in small cell and non-small cell carcinoma of the lung
23. Multiple steps in carcinogenesis involving alterations of multiple tumour suppressor genes
24. Structure and chromosome location of human OGG1
25. Mutations in OGG1 a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours
26. Frequent allelic loss at chromosome 3p distinct from genetic alterations of the 8-oxoguanine DNA glycosylase 1 gene in head and neck cancer
27. New DNA polymorphisms of human MMH/OGG1 gene: Prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese
28. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA
29. 326) protein which is frequently found in human populations
30. Activity of O-6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students
31. A method for the cryopreservation of liver parenchymal cells for studies of xenobiotics
32. Synthesis of 2′-deoxy-7, 8-dihydro-8-oxoguanosine and 2′-deoxy-7, 8-dihydro-8-oxoadenosine and their incorporation into oligomeric DNA
33. Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells
34. Expression and differential intracellular localisation of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs
35. An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA
36. Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking
37. Reduced DNA repair capacity in lung cancer patients
38. Environment and cancer: Who are susceptible
39. Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells
40. 326Cys polymorphism and lung cancer susceptibility
41. Comparative repair of the endogenous lesions 8-oxo-7, 8-dihydroguanine (8-oxoG), uracil and abasic site by mammalian cell extracts: 8-oxoG is poorly repaired by human cell extracts
42. Enhanced excision repair activity in mammalian cells after ionising radiation
43. Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administration of a renal carcinogen, ferric nitrilotriacetate