Atorvastatin improves sodium handling and decreases blood pressure in salt-loaded rats with chronic renal insufficiency

Nutrition

Volumn 28, Issue 9, 2012, Pages

  Juncos, Luis I ^a   Martín, Fernando L ^b   Baigorria, Sandra T ^a   Pasqualini, María E ^c   Fiore, María C ^a   Eynard, Aldo R ^c   Juncos, Luis A ^d   García, Néstor H ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b MAYO CLINIC   (United States)

^c FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^d UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Hydroxymethyl glutaryl coenzyme A reductase inhibition; Nitric oxide oxidant stress; Renal failure; Salt sensitivity; Sodium balance

Indexed keywords

12 HYDROXY 5,8,10 HEPTADECATRIENOIC ACID; ATORVASTATIN; CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID DERIVATIVE; NITRITE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; BODY WEIGHT; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE MODEL; HEART LEFT VENTRICLE; HEART WEIGHT; HYPERTENSION; KIDNEY CORTEX; KIDNEY MASS; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; SALT LOADING; SODIUM BALANCE; SODIUM METABOLISM; SODIUM RETENTION; SPRAGUE DAWLEY RAT; TISSUE INJURY;

ANIMALS; BLOOD PRESSURE; CREATININE; DIET; FATTY ACIDS, UNSATURATED; HEART VENTRICLES; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION; KIDNEY; MALE; NEPHRECTOMY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PROTEINURIA; PYRROLES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC; SODIUM; SODIUM CHLORIDE, DIETARY;

RATTUS;

EID: 84864516351     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2012.02.008     Document Type: Article

References (38)

1. Levitan E., Wolk A., Mittleman M. Consistency with the DASH diet and incidence of heart failure. Arch Intern Med 2009, 169:851-857.
2. Pauline A.Swift PA, Markandu N., Sagnella G., He F., MacGregor G. Modest salt reduction reduces blood pressure and urine protein excretion in black hypertensives. Hypertension 2005, 46:308-312.
3. Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ 1988, 297:319-328. Intersalt Cooperative Research Group.
4. Morimoto A., Uzu T., Fujii T., Nishimura M., Kuroda S., Nakamura S., et al. Sodium sensitivity and cardiovascular events in patients with essential hypertension. Lancet 1997, 350:1734-1774.
5. Weinberger M., Fineberg N., Fineberg S., Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension 2001, 37:429-432.
6. Du Cailar G., Ribstein J., Mimran A. Dietary sodium and target organ damage in essential hypertension. Am J Hypertens 2002, 26:670-675.
7. Mistrik E., Dusilova-Sulkova S., Blaha V., Sobotka L. Plasma albumin levels correlate with decreased microcirculation and the development of skin defects in hemodialyzed patients. Nutrition 2010, 26:880-885.
8. Zhou M., Jaimes E., Raij L. Atorvastatin prevents end-organ injury in salt-sensitive hypertension: role of eNOS and oxidant stress. Hypertension 2004, 44:186-190.
9. Tian N., Thrasher K.D., Gundy P.D., Hughson M.D., Manning R.D. Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Hypertension 2005, 45:934-939.
10. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389.
11. Sacks F.M., Pfeffer M.A., Moye L.A., Rouleau J.L., Rutherford J.D., Cole T.G., et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996, 335:1001-1009.
12. Yao K., Sato H., Ina Y., Suzuki K., Ohno T., Shirakura S. Renoprotective effects of benidipine in combination with angiotensin II type I receptor blocker in hypertensive Dahl rats. Hypertens Res 2003, 26:635-641.
13. Zhou M., Hernandez S., Jaimes E., Raij L. Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-β, and fibronectin with concomitant increase in nitric oxide bioavailability. Am J Physiol Renal Physiol 2008, 295:F53-F59.
14. Varela M., Garvin J. Acute and chronic regulation of thick ascending limb endothelial nitric oxide synthase by statins. J Am Soc Nephrol 2004, 15:269-275.
15. Plastaras J.P., Guengerich F.P., Nebert D.W., Marnett L.J. Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. J Biol Chem 2000, 275:11784-11790.
16. Cambiasso M., Colombo J., Carrer H. Differential effect of oestradiol and astroglia-conditioned media on the growth of hypothalamic neurons from male and female rat brains. Eur J Neurosci 2000, 7:2291-2298.
17. García N., Baigorria S., Juncos L. Hyperkalemia, renal failure and converting enzyme inhibition. An overrated connection. Hypertension 2001, 38:639-644.
18. Yen P.L., Chen B.H., Yang F.L., Lu Y.F. Effects of deep-frying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats. Nutrition 2010, 26:331-336.
19. Carroll M., Giff M., Ferreri N. Regulation of preglomerular microvascular 20-hydroxyeicosatetraenoic acid levels by salt depletion. Med Sci Monit 2001, 7:567-572.
20. Pasqualini M., Berra M., Calderón R., Cremonezzi D., Giraudo C., Eynard A. Dietary lipids modulate eicosanoid release and apoptosis of cells of a murine lung alveolar carcinoma. Prostaglandins Leukot Essent Fatty Acids 2005, 72:235-240.
21. Rittie L., Monboisse J.C., Gorisse M.C., Gillery P. Malondialdehyde binding to proteins dramatically alters fibroblast functions. J Cell Physiol 2002, 191:227-236.
22. Vaziri N.D., Ni Z., Oveisi F., Liang K., Pandian R. Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency. Hypertension 2002, 39:135-141.
23. Arnal J., Amrani A., Chatellier G., Menard J., Michel J. Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension 1993, 22:380-387.
24. Yu H., Burrell L., Black M., Wu L., Dilley R., Cooper M., et al. Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation 1998, 98:2621-2828.
25. Annuk M., Zilmer M., Lind L., Linde T., Fellström B. Oxidative stress and endothelial function in chronic renal failure. J Am Soc Nephrol 2001, 12:2747-2752.
26. Bragulat E., De la Sierra A., Antonio M.T., Coca A. Endothelial dysfunction in salt-sensitive essential hypertension. Hypertension 2001, 37:444-448.
27. Marcantoni C., Jafar T.H., Oldrizzi L., Levey A., Maschio G. The role of systemic hypertension in the progression of nondiabetic renal disease. Kidney Int 2000, 57:44-48.
28. Rennke H., Anderson S., Brenner B. Structural and functional correlations in the progression of renal disease. Renal pathology 1989, 43-66. Lippincott, Philadelphia. C.C. Tisher, B.M. Brenner (Eds.).
29. Jiang J., Roman R.J. Lovastatin prevents development of hypertension in spontaneously hypertensive rats. Hypertension 1997, 30:968-974.
30. Naumnik B., Mysliwiec M. Renal consequences of obesity. Med Sci Monit 2010, 16(8):RA163-RA170.
31. Lyang M., Knox F.G. Nitric oxide enhances paracellular permeability of opossum kidney cells. Kidney Int 1999, 55:2215-2223.
32. Wassmann S., Laufs U., Bäumer A., Müller K., Ahlbory K., Linz W., et al. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension 2001, 37:1450-1457.
33. Osanai T., Fujiwara N., Saitoh M., Sasaki S., Tomita H., Nakamura M., et al. Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease. Blood Purif 2002, 20:466-468.
34. Park J., Muller D., Mervaala E., Dechend R., Fiebeler A., Schmidt F., et al. Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects. Kidney Int 2000, 58:1420-1430.
35. Fiore M.C., Jimenez P.M., Cremonezzi D., Juncos L.I., García N.H. Statins reverse renal inflammation and endothelial dysfunction induced by chronic high salt intake. Am J Physiol Renal Physiol 2011, 301:F263-F270.
36. Richer-Giudicelli C., Domergue V., Gonzalez M., Messadi E., Azizi M., Giudicelli J., et al. Haemodynamic effects of dual blockade of the renin-angiotensin system in spontaneously hypertensive rats: influence of salt. J Hypertens 2004, 22:619-627.
37. Matavelli L., Zhou X., Varagic J., Susic D., Frohlich E. Salt loading produces severe renal hemodynamic dysfunction independent of arterial pressure in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2007, 292:H814-H819.
38. Melanson K. Practical dietary approaches to reducing risk of cardiovascular diseases. Am J Lifestyle Med 2007, 1:95-98.