Binding of indanocine to the colchicine site on tubulin promotes fluorescence, and its binding parameters resemble those of the colchicine analogue AC

Biochemistry

Volumn 48, Issue 7, 2009, Pages 1628-1635

  Das, Lalita ^a   Gupta, Suvroma ^a   Dasgupta, Dipak ^b   Poddar, Asim ^a   Janik, Mark E ^c   Bhattacharyya, Bhabatarak ^a  

^a BOSE INSTITUTE   (India)

^b SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

^c STATE UNIVERSITY OF NEW YORK AT FREDONIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROLIFERATIVE ACTIVITIES; AQUEOUS SOLUTIONS; ASSOCIATION PROCESS; BI-PHASIC KINETICS; BINDING KINETICS; BINDING PARAMETERS; BINDING PROPERTIES; BLUE SHIFTS; COLCHICINE BINDINGS; EMISSION MAXIMUM; FASTER RATES; FLEXIBLE MOLECULES; HEAT CAPACITY CHANGES; HYDROGEN BONDINGS; ISOTHERMAL TITRATION CALORIMETRIES; MICROTUBULE; MULTI-DRUG RESISTANCES; SINGLE BONDS; STOPPED FLOWS; STRUCTURAL SIMILARITIES; THERMODYNAMIC PARAMETERS;

ACTIVATION ENERGY; ASSOCIATION REACTIONS; BINDING ENERGY; ENCODING (SYMBOLS); FLUORESCENCE; HYDROGEN; HYDROGEN BONDS;

BINDING SITES;

COLCHICINE DERIVATIVE; INDANOCINE; INDANONE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; BIOPOLYMER; COLCHICINE; DRUG DERIVATIVE; INDAN DERIVATIVE;

ARTICLE; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENTHALPY; FLUORESCENCE; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; THERMODYNAMICS; CALORIMETRY; KINETICS; METABOLISM;

BINDING SITES; BIOPOLYMERS; CALORIMETRY; COLCHICINE; FLUORESCENCE; INDANS; KINETICS; THERMODYNAMICS; TUBULIN;

MACULINEA ARION;

EID: 61749088240     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801575e     Document Type: Article

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