Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 2, 2012, Pages 352-358

  Rattanakiat, Sakulrat ^a   Nishikawa, Makiya ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Antigen presenting cell; Cholesterol; CpG DNA; Nanoparticle; Self assembly

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN G2A; NANOPARTICLE; OVALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DELIVERY SYSTEM; DRUG STABILITY; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; CELL LINE; CHOLESTEROL; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN G; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; NANOPARTICLES; OLIGODEOXYRIBONUCLEOTIDES; OVALBUMIN; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864405579     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.06.015     Document Type: Article

References (48)

1. K. Akiyoshi, S. Deguchi, N. Moriguchi, S. Yamaguchi, and J. Sunamoto Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles Macromolecules 26 1993 3062 3068
2. K. Akiyoshi, S. Kobayashi, S. Shichibe, D. Mix, M. Baudys, S.W. Kim, and J. Sunamoto Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin J. Control. Rel. 54 1998 313 320
3. M.K. Bijsterbosch, E.T. Rump, R.L.A.D. Vrueh, R. Dorland, R. van Veghel, K.L. Tivel, E.A.L. Biessen, T.J.C. van Berkel, and M. Manoharan Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation Nucl. Acids Res. 28 2000 2717 2725
4. M.K. Bijsterbosch, M. Manoharan, R. Dorland, R. van Veghel, E.A.L. Biessen, and T.J.C. van Berkel Bis-cholesteryl-conjugated phosphorothioate oligodeoxynucleotides are highly selectively taken up by the liver J. Pharmacol. Exp. Ther. 302 2002 619 626
5. J.M. Blander, and R. Medzhitov Regulation of phagosome maturation by signals from Toll-like receptors Science 304 2004 1014 1018
6. K. Cheng, Z. Ye, R.V. Guntaka, and R.I. Mahato Enhanced hepatic uptake and bioactivity of type α 1(I) collagen gene promoter-specific triplex-forming oligonucleotides after conjugation with cholesterol J. Pharmacol. Exp. Ther. 317 2006 797 805
7. M.F. Delgado, S. Coviello, A.C. Monsalvo, G.A. Melendi, J.Z. Hernandez, J.P. Batalle, L. Diaz, A. Trento, H.-Y. Chang, W. Mitzner, J. Ravetch, J.A. Melero, P.M. Irusta, and F.P. Polack Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease Nat. Med. 15 2009 34 41
8. P.M. Dentinger, B.A. Simmons, E. Cruz, and M. Sprague DNA-mediated delivery of lipophilic molecules via hybridization to DNA-based vesicular aggregates Langmuir 22 2006 2935 2937
9. B.M. Discher, D.A. Hammer, F.S. Bates, and D.E. Discher Polymer vesicles in various media Curr. Opin. Colloid Interface Sci. 5 2000 125 131
10. H.B. Gamper, M.W. Reed, T. Cox, J.S. Virosco, A.D. Adams, A.A. Gall, J.K. Scholler, and R.B. Meyer Jr. Facile preparation of nuclease resistant 3′ modified oligodeoxynucleotides Nucl. Acids Res. 21 1993 145 150
11. C. Gosse, A. Boutorine, I. Aujard, M. Chami, A. Kononov, E. Cogne-Laage, J.F. Allemand, J. Li, and L. Jullien Micelles of lipid-oligonucleotide conjugates: implications for membrane anchoring and base pairing J. Phys. Chem. B 108 2004 6485 6497
12. G. Hartmann, G.J. Weiner, and A.M. Krieg CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells Proc. Natl. Acad. Sci. USA 96 1999 9305 9310
13. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira A Toll-like receptor recognizes bacterial DNA Nature 408 2000 740 745
14. . Holasová, M. Mojíek, M. Bunek, D. Vokurková, H. Radilová, M. afáová, M. ervinka, and R. Haluza Cholesterol conjugated oligonucleotide and LNA: a comparison of cellular and nuclear uptake by Hep2 cells enhanced by Streptolysin-O Mol. Cell. Biochem. 276 2005 61 69
15. R. Juliano, M.R. Alam, V. Dixit, and H. Kang Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides Nucl. Acids Res. 36 2008 4158 4171
16. V. Kanchan, and A.K. Panda Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response Biomaterials 28 2007 5344 5357
17. E.R. Kandimalla, L. Bhagat, D. Yu, Y. Cong, J. Tang, and S. Agrawal Conjugation of ligands at the 5′-end of CpG DNA affects immunostimulatory activity Bioconjug. Chem. 13 2002 966 974
18. M. Kirkham, and R.G. Parton Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers Biochim. Biophys. Acta 1746 2005 350 363
19. Klier, J., Fuchs, S., May, A., Schillinger, U., Plank, C., Winter, G., Gehlen, H., Coester, C., 2012. A nebulized gelatin nanoparticle-based CpG formulation is effective in immunotherapy of allergic horses. Pharm Res. 29, 1650-1657.
20. D.M. Klinman, K.M. Barnhart, and J. Conover CpG motifs as immune adjuvants Vaccine 17 1999 19 25
21. D.M. Klinman, D. Currie, I. Gursel, and D. Verthelyi Use of CpG oligodeoxynucleotides as immune adjuvants Immunol. Rev. 199 2004 201 216
22. A.M. Krieg CpG motifs in bacterial DNA and their immune effects Annu. Rev. Immunol. 20 2002 709 760
23. A.M. Krieg CpG motifs: the active ingredient in bacterial extracts? Nat. Med. 9 2003 831 835
24. Y. Krishnamachari, and A.K. Salem Innovative strategies for co-delivering antigens and CpG oligonucleotides Adv. Drug Deliv. Rev. 61 2009 205 217
25. Y. Kuramoto, M. Nishikawa, K. Hyoudou, F. Yamashita, and M. Hashida Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex J. Control. Rel. 115 2006 226 233
26. R.L. Letsinger, G.R. Zhang, D.K. Sun, T. Ikeuchi, and P.S. Sarin Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture Proc. Natl. Acad. Sci. USA 86 1989 6553 6556
27. C. Lorenz, P. Hadwiger, M. John, H.-P. Vornlocher, and C. Unverzagt Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells Bioorg. Med. Chem. Lett. 14 2004 4975 4977
28. M.J. McCluskie, and H.L. Davis Cutting edge: CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice J. Immunol. 161 1998 4463 4466
29. G.K. Mutwiri, A.K. Nichani, S. Babiuk, and L.A. Babiuk Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides J. Control. Rel. 97 2004 1 17
30. A. Oxenius, M.M.A. Martinic, H. Hengartner, and P. Klenerman CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines J. Virol. 73 1999 4120 4126
31. D.D. Paula, M. Vitória, L.B. Bentley, and R.I. Mahato Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting RNA 13 2007 431 456
32. A. Rösler, G.W.M. Vandermeulen, and H.-A. Klok Advanced drug delivery devices via self-assembly of amphiphilic block copolymers Adv. Drug Deliv. Rev. 53 2001 95 108
33. E.T. Rump, R.L.A. de Vrueh, L.A.J.M. Sliedregt, E.A.L. Biessen, T.J.C. van Berkel, and M.K. Bijsterbosch Preparation of conjugates of oligodeoxynucleotides and lipid structures and their interaction with low-density lipoprotein Bioconjug. Chem. 9 1998 341 349
34. A.S. Ryte, V.N. Karamyshev, M.V. Nechaeva, Z.V. Guskova, E.M. Ivanova, V.F. Zarytova, and V.V. Vlassov Interaction of cholesterol-conjugated alkylating oligonucleotide derivatives with cellular biopolymers FEBS Lett. 299 1992 124 126
35. A.K. Salem, C.F. Hung, T.W. Kim, T.C. Wu, P.C. Searson, and K.W. Leong Multi-component nanorods for vaccination applications Nanotechnology 16 2005 484 487
36. A.D. Sandler, H. Chihara, G. Kobayashi, X. Zhu, M.A. Miller, D.L. Scott, and A.M. Krieg CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma Cancer Res. 63 2003 394 399
37. J.P. Shaw, K. Kent, J. Bird, J. Fishback, and B. Froehler Modified deoxyoligonucleotides stable to exonuclease degradation in serum Nucl. Acids Res. 19 1991 747 750
38. J. Soutschek, A. Akinc, B. Bramlage, K. Charisse, R. Constien, M. Donoghue, S. Elbashir, A. Geick, P. Hadwiger, J. Harborth, M. John, V. Kesavan, G. Lavine, R.K. Pandey, T. Racie, K.G. Rajeev, I. Rohl, I. Toudjarska, G. Wang, S. Wuschko, D. Bumcrot, V. Koteliansky, S. Limmer, M. Manoharan, and H.-P. Vornlocher Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs Nature 432 2004 173 178
39. F. Teixeira, P. Rigler, and C. Vebert-Nardin Nucleo-copolymers: oligonucleotide-based amphiphilic diblock copolymers Chem. Commun. 11 2007 1130 1132
40. K. Tsuji, T. Hamada, A. Uenaka, H. Wada, E. Sato, M. Isobe, K. Asagoe, O. Yamasaki, H. Shiku, G. Ritter, R. Murphy, E. Hoffman, L. Old, E. Nakayama, and K. Iwatsuki Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient Cancer Immunol. Immunother. 57 2008 1429 1437
41. J. Vollmer, and A.M. Krieg Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists Adv. Drug Deliv. Rev. 61 2009 195 204
42. H. Wang, E. Rayburn, and R. Zhang Synthetic oligodeoxynucleotides containing deoxycytidyl-deoxyguanosine dinucleotides (CpG ODNs) and modified analogs as novel anticancer therapeutics Curr. Pharm. Des. 11 2005 2889 2907
43. T.L. Warren, S.K. Bhatia, A.M. Acosta, C.E. Dahle, T.L. Ratliff, A.M. Krieg, and G.J. Weiner APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells J. Immunol. 165 2000 6244 6251
44. M. Wei, N. Chen, J. Li, M. Yin, L. Liang, Y. He, H. Song, C. Fan, and Q. Huang Polyvalent immunostimulatory nanoagents with self-assembled CpG oligonucleotide-conjugated gold nanoparticles Angew. Chem. Int. Ed. Engl. 51 2012 1202 1206
45. G.J. Weiner, H.-M. Liu, J.E. Wooldridge, C.E. Dahle, and A.M. Krieg Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization Proc. Natl. Acad. Sci. USA 94 1997 10833 10837
46. C. Wolfrum, S. Shi, K.N. Jayaprakash, M. Jayaraman, G. Wang, R.K. Pandey, K.G. Rajeev, T. Nakayama, K. Charrise, E.M. Ndungo, T. Zimmermann, V. Koteliansky, M. Manoharan, and M. Stoffel Mechanisms and optimization of in vivo delivery of lipophilic siRNAs Nat. Biotechnol. 25 2007 1149 1157
47. L.A. Yakubov, E.A. Deeva, V.F. Zarytova, E.M. Ivanova, A.S. Ryte, L.V. Yurchenko, and V.V. Vlassov Mechanism of oligonucleotide uptake by cells: involvement of specific receptors? Proc. Natl. Acad. Sci. USA 86 1989 6454 6458
48. Z. Zhao, and K.W. Leong Controlled delivery of antigens and adjuvants in vaccine development J. Pharm. Sci. 85 1996 1261 1270