Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers

Chemistry and Biology

Volumn 19, Issue 7, 2012, Pages 799-805

  Aye, Yimon ^a   Brignole, Edward J ^a,b   Long, Marcus J C ^c   Chittuluru, Johnathan ^b   Drennan, Catherine L ^a   Asturias, Francisco J ^b   Stubbe, Joanne ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOFARABINE; OLIGOMER; RIBONUCLEOTIDE REDUCTASE;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TARGETING; ELECTRON MICROSCOPY; ENZYME KINETICS; GEL PERMEATION CHROMATOGRAPHY; LIGAND BINDING; LIVER CELL; MAMMAL CELL; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE;

ADENINE NUCLEOTIDES; ARABINONUCLEOSIDES; CELL SURVIVAL; HUMANS; KINETICS; LIVER; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; RIBONUCLEOTIDE REDUCTASES;

MAMMALIA;

EID: 84864402197     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.05.015     Document Type: Article

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